Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Richard L. Davidson"'
Autor:
Richard L. Davidson, Thomas P. Powers
Publikováno v:
Somatic Cell and Molecular Genetics. 22:41-56
Whole cell hybrids and microcell hybrids between mouse fibroblasts and pigmented Syrian hamster melanoma cells were analyzed for coordinate regulation of melanocyte-specific gene products. Extinction of pigmentation was observed in whole-cell hybrids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c74ee0e2d10094923035c7374cb4fa
https://doi.org/10.1007/bf02374375
https://doi.org/10.1007/bf02374375
Publikováno v:
Molecular and Cellular Biology. 14:1179-1190
Human and mouse fibroblast chromosomes carrying tyrosinase or b-locus genes were introduced, by microcell hybridization, into pigmented Syrian hamster melanoma cells, and the microcell hybrids were tested for transactivation of the fibroblast tyrosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f77b05390081b7f4681cdea5d9c6b202
https://doi.org/10.1128/mcb.14.2.1179
https://doi.org/10.1128/mcb.14.2.1179
Autor:
Richard L. Davidson, Mark T. Kresnak
Publikováno v:
Somatic Cell and Molecular Genetics. 19:589-598
We have previously demonstrated that mutagenesis by bromodeoxyuridine (BrdU) and thymidine (dT) in mammalian cells occurs with a high degree of sequence specificity within runs of multiple adjacent guanine residues. To determine whether there is a st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a3ef2d0b578756fa30ea18a167d49e
https://doi.org/10.1007/bf01233386
https://doi.org/10.1007/bf01233386
Autor:
Sikha Rauth, Richard L. Davidson
Publikováno v:
Somatic Cell and Molecular Genetics. 19:285-293
5-Bromodeoxyuridine (BrdU), a thymidine analog, suppresses melanogenesis in Syrian hamster melanoma cells. Tyrosinase, which is the key enzyme for the synthesis of melanin, is suppressed by exposure to BrdU, and the drop in enzyme activity is correla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af8912a074d93c685684669fe106cd2b
https://doi.org/10.1007/bf01233076
https://doi.org/10.1007/bf01233076
Autor:
Mark T. Kresnak, Richard L. Davidson
Publikováno v:
Proceedings of the National Academy of Sciences. 89:2829-2833
Imbalances in the intracellular nucleotide precursor pools in mammalian cells can result in the induction of mutations during the DNA replication process. By using a shuttle vector system developed in our laboratory, we have analyzed the sequence spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3edb00b2e4907d9436671e472dfd7d
https://doi.org/10.1073/pnas.89.7.2829
https://doi.org/10.1073/pnas.89.7.2829
Publikováno v:
Somatic Cell and Molecular Genetics. 16:477-486
The molecular mechanism of reversion induced by 5-bromodeoxyuridine (BrdU) replication-dependent mutagenesis in mammalian cells was studied. Murine cells with single mutant copies of the E. coli gpt gene integrated chromosomally as part of a shuttle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4eaadd12b7e1b5dc32523d0be729b31
https://doi.org/10.1007/bf01233197
https://doi.org/10.1007/bf01233197
Publikováno v:
Molecular and cellular biology. 14(2)
Human and mouse fibroblast chromosomes carrying tyrosinase or b-locus genes were introduced, by microcell hybridization, into pigmented Syrian hamster melanoma cells, and the microcell hybrids were tested for transactivation of the fibroblast tyrosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c4857f4ae0d5373641668316c38f8b
https://pubmed.ncbi.nlm.nih.gov/8289799
https://pubmed.ncbi.nlm.nih.gov/8289799
Publikováno v:
Somatic cell and molecular genetics. 18(2)
For studies on molecular mechanisms of mutagenesis, it would be advantageous to transfer mutant genes with specific alterations into mammalian cells and use the transformed cells in reversion analyses. In the present paper, we describe an efficient m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0b42a946a51a179ca8b7d11384815c
https://pubmed.ncbi.nlm.nih.gov/1315457
https://pubmed.ncbi.nlm.nih.gov/1315457
Autor:
Mark T. Kresnak, Richard L. Davidson
Publikováno v:
Somatic cell and molecular genetics. 17(4)
The molecular mechanisms of incorporation-dependent, 5-bromodeoxyuridine (BrdU)-induced mutagenesis were analyzed in murine A9 cells that possess a single copy of the Escherichia coli gpt gene integrated into the chromosomal DNA as part of a shuttle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0fef3b5abdaac71caa92e8c3f3c9fe2
https://pubmed.ncbi.nlm.nih.gov/1887336
https://pubmed.ncbi.nlm.nih.gov/1887336
Bromodeoxyuridine- and cyclic AMP-mediated regulation of tyrosinase in Syrian hamster melanoma cells
Publikováno v:
Somatic cell and molecular genetics. 16(6)
The thymidine analog 5-bromodeoxyuridine (BrdU) suppresses pigmentation and tyrosinase activity in Syrian hamster melanoma cells W1-1-1. Studies on the molecular mechanism of suppression of pigmentation indicated that BrdU treatment affects the level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304a431c85510a22cfa8dca69027e2c2
https://pubmed.ncbi.nlm.nih.gov/2176354
https://pubmed.ncbi.nlm.nih.gov/2176354