Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Richard L. Carpenter"'
Autor:
John C. Smith, Stefan Husted, Jay Pilrose, Stephanie C. Ems-McClung, Jane R. Stout, Richard L. Carpenter, Claire E. Walczak
Publikováno v:
Cancers, Vol 16, Iss 2, p 293 (2024)
The authors alerted the Editorial Office of the mistake on 5 August 2023 and the final documents were sent for evaluation on 12 December 2023 [...]
Externí odkaz:
https://doaj.org/article/32695ad1e9e84ddfb9b1c1d844299ef5
Autor:
Xiang Li, Shaomin Wang, Wei Mu, Jennifer Barry, Anna Han, Richard L. Carpenter, Bing-Hua Jiang, Stephen C. Peiper, Mỹ G. Mahoney, Andrew E. Aplin, Hong Ren, Jun He
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-19 (2022)
Abstract Background Cancer cells have an imbalance in oxidation-reduction (redox) homeostasis. Understanding the precise mechanisms and the impact of the altered redox microenvironment on the immunologic reaction to tumors is limited. Methods We isol
Externí odkaz:
https://doaj.org/article/54c8d14e4d4c415ea3b2296caa6d7c60
Autor:
John C. Smith, Stefan Husted, Jay Pilrose, Stephanie C. Ems-McClung, Jane R. Stout, Richard L. Carpenter, Claire E. Walczak
Publikováno v:
Cancers, Vol 15, Iss 13, p 3309 (2023)
Standard of care for triple-negative breast cancer (TNBC) involves the use of microtubule poisons such as paclitaxel, which are proposed to work by inducing lethal levels of aneuploidy in tumor cells. While these drugs are initially effective in trea
Externí odkaz:
https://doaj.org/article/b38aa553328f4807a0617d3e8e9fd0b9
294 Identification of MCAK Inhibitors that Induce Aneuploidy in Triple Negative Breast Cancer Models
Autor:
John Smith, Stefan Husted, Jay Pilrose, Disha Kuchangi, Stephanie C. Ems-McClung, Richard L. Carpenter, Claire E. Walczak
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 88-88 (2023)
OBJECTIVES/GOALS: Microtubule poisons, like Taxol, are used to treat triple negative breast cancer (TNBC) and may induce lethal aneuploidy in cancer cells. Patients initially respond, but often develop drug resistance. New targeted drugs that cause a
Externí odkaz:
https://doaj.org/article/f7ae9f0c09394593a916ba7b9b8be76b
Autor:
Richard L. Carpenter, Hui-Wen Lo
Publikováno v:
Cancers, Vol 6, Iss 2, Pp 897-925 (2014)
Since its discovery, the STAT3 transcription factor has been extensively studied for its function as a transcriptional regulator and its role as a mediator of development, normal physiology, and pathology of many diseases, including cancers. These ef
Externí odkaz:
https://doaj.org/article/c4d8083c8e494e94839dee2c0e84aed4
Publikováno v:
Cancers, Vol 8, Iss 2, p 22 (2016)
The sonic hedgehog (Shh) signaling pathway is a major regulator of cell differentiation, cell proliferation, and tissue polarity. Aberrant activation of the Shh pathway has been shown in a variety of human cancers, including, basal cell carcinoma, ma
Externí odkaz:
https://doaj.org/article/c6a6d8e654454eeabdc6409766b1f6e4
Autor:
Walczak, John C. Smith, Stefan Husted, Jay Pilrose, Stephanie C. Ems-McClung, Jane R. Stout, Richard L. Carpenter, Claire E.
Publikováno v:
Cancers; Volume 15; Issue 13; Pages: 3309
Standard of care for triple-negative breast cancer (TNBC) involves the use of microtubule poisons such as paclitaxel, which are proposed to work by inducing lethal levels of aneuploidy in tumor cells. While these drugs are initially effective in trea
Autor:
Tadas K. Rimkus, Austin B. Arrigo, Dongqin Zhu, Richard L. Carpenter, Sherona Sirkisoon, Daniel Doheny, Angelina T. Regua, Grace L. Wong, Sara Manore, Calvin Wagner, Hui-Kuan Lin, Guangxu Jin, Jimmy Ruiz, Michael Chan, Waldemar Debinski, Hui-Wen Lo
Publikováno v:
Cancer Lett
Whether tumor suppressor candidate 2 (TUSC2) plays an important role in glioblastoma (GBM) progression is largely unknown. Whether TUSC2 undergoes polyubiquitination is unknown. Herein, we report that TUSC2 protein expression is reduced/lost in GBM c
Autor:
Kounosuke Watabe, Boris Pasche, Shadi A. Qasem, Xiaobo Zhou, Linda J. Metheny-Barlow, Richard L. Carpenter, Hui-Wen Lo, Michael D. Chan, Kerui Wu, Sambad Sharma, Yin Liu, Fei Xing
Brain metastasis is one of the chief causes of mortality in breast cancer patients, but the mechanisms that drive this process remain poorly understood. Here, we report that brain metastatic cells expressing high levels of c-Met promote the metastati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::140f591d4f70e790e49a5533c51b9500
https://doi.org/10.1158/0008-5472.c.6508764.v1
https://doi.org/10.1158/0008-5472.c.6508764.v1
Autor:
Hui-Wen Lo, Waldemar Debinski, Kounosuke Watabe, Stephen B. Tatter, Glenn J. Lesser, Michael D. Chan, Boris C. Pasche, Dongqin Zhu, Sherona Sirkisoon, Richard L. Carpenter, Tadas K. Rimkus
The molecular pathways driving mesenchymal glioblastoma (GBM) are still not well understood. We report here that truncated glioma-associated oncogene homolog 1 (tGLI1) is a tumor-specific transcription factor that facilitates GBM growth, is enriched
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b98059fed05947ea6aa0b63eb4ba3805
https://doi.org/10.1158/0008-5472.c.6510272.v1
https://doi.org/10.1158/0008-5472.c.6510272.v1