Interleukin-33 primes mast cells for activation by IgG immune complexes.

Autor: Shinjiro Kaieda, Jun-Xia Wang, Ruslan Shnayder, Nadia Fishgal, Hillary Hei, Richard T Lee, Richard L Stevens, Peter A Nigrovic

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e47252 (2012)

Mast cells (MCs) are heterogeneous cells whose phenotype is modulated by signals received from the local microenvironment. Recent studies have identified the mesenchymal-derived cytokine IL-33 as a potent direct activator of MCs, as well as regulator

Externí odkaz: https://doaj.org/article/6c3e5aa31d754a80889cd7613f7c7622

Ras Guanine Nucleotide–Releasing Protein 4 Is Aberrantly Expressed in the Fibroblast‐like Synoviocytes of Patients With Rheumatoid Arthritis and Controls Their Proliferation

Autor: Toshiyuki Bohgaki, Tetsuya Horita, Michihito Kono, Yuka Shimizu, Olga Amengual, Richard L. Stevens, Yusaku Kanetsuka, Tomohiro Shimizu, Takashi Kurita, Shinsuke Yasuda, Takao Koike, Tatsuya Atsumi, Hideyuki Koide, Tokifumi Majima, Kenji Oku

Publikováno v: Arthritis & Rheumatology. 67:396-407

Objective Ras guanine nucleotide–releasing protein 4 (RasGRP-4) is a calcium-regulated guanine nucleotide exchange factor and diacylglycerol/phorbol ester receptor not normally expressed in fibroblasts. While RasGRP-4–null mice are resistant to a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d37a69bc0220e5fff60134371eaf977
https://doi.org/10.1002/art.38924

Mast Cell–Restricted, Tetramer-Forming Tryptases Induce Aggrecanolysis in Articular Cartilage by Activating Matrix Metalloproteinase-3 and -13 Zymogens

Autor: Katherine Bryant, Amanda J. Fosang, H. Patrick McNeil, Richard L. Stevens, Natalia J. Magarinos, Roberto Adachi

Publikováno v: The Journal of Immunology. 191:1404-1412

Mouse mast cell protease (mMCP)-6–null C57BL/6 mice lost less aggrecan proteoglycan from the extracellular matrix of their articular cartilage during inflammatory arthritis than wild-type (WT) C57BL/6 mice, suggesting that this mast cell (MC)–spe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74ec7a525c2c33610311f30c74f53ce
https://doi.org/10.4049/jimmunol.1300856

The translational repressor T-cell intracellular antigen-1 (TIA-1) is a key modulator of Th2 and Th17 responses driving pulmonary inflammation induced by exposure to house dust mite

Autor: Wei Xing, Maria Simarro, Richard L. Stevens, Antonio Orduña, Paul A. Anderson, Samantha Stewart, Giorgio Giannattasio, Emma-Maria Lundequist, Joshua A. Boyce

Publikováno v: Immunology Letters. 146:8-14

T-cell intracellular antigen-1 (TIA-1) is a translational repressor that dampens the production of proinflammatory cytokines and enzymes. In this study we investigated the role of TIA-1 in a mouse model of pulmonary inflammation induced by exposure t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d78fb1ea2f5680dfd2e7a2e54cd52eb
https://doi.org/10.1016/j.imlet.2012.04.001

Mast Cell Tryptase Deficiency Attenuates Mouse Abdominal Aortic Aneurysm Formation

Autor: Jie Zhang, Galina K. Sukhova, Richard L. Stevens, Mark J. Sinnamon, Jes S. Lindholt, Robert W. Thompson, Guo-Ping Shi, Jiusong Sun, Roberto Adachi, Peter Libby

Publikováno v: Zhang, J, Sun, J, Lindholt, J S, Sukhova, G K, Sinnamon, M, Stevens, R L, Adachi, R, Libby, P, Thompson, R W & Shi, G-P 2011, ' Mast cell tryptase deficiency attenuates mouse abdominal aortic aneurysm formation ', Circulation Research, vol. 108, no. 11, pp. 1316-27 . https://doi.org/10.1161/CIRCRESAHA.111.243758
Circulation Research; Vol 108

Rationale: Mast cells (MCs) contribute to the formation of abdominal aortic aneurysms (AAAs) by producing biologically active mediators. Tryptase is the most abundant MC granule protein and participates in MC activation, protease maturation, leukocyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99358511d9d46233278a4ee28f9fb047
https://doi.org/10.1161/circresaha.111.243758