Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Richard L M, Faull"'
Autor:
Florian Ermini, Victoria F. Low, Jennifer J. Song, Adelie Y. S. Tan, Richard L. M. Faull, Michael Dragunow, Maurice A. Curtis, Stephen S. Dominy
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-16 (2024)
Abstract Gingipains are protease virulence factors produced by Porphyromonas gingivalis, a Gram-negative bacterium best known for its role in chronic periodontitis. Gingipains were recently identified in the middle temporal gyrus of postmortem Alzhei
Externí odkaz:
https://doaj.org/article/e8b7aafa120347438648a23f9c4049de
Autor:
Rebecca San Gil, Dana Pascovici, Juliana Venturato, Heledd Brown-Wright, Prachi Mehta, Lidia Madrid San Martin, Jemma Wu, Wei Luan, Yi Kit Chui, Adekunle T. Bademosi, Shilpa Swaminathan, Serey Naidoo, Britt A. Berning, Amanda L. Wright, Sean S. Keating, Maurice A. Curtis, Richard L. M. Faull, John D. Lee, Shyuan T. Ngo, Albert Lee, Marco Morsch, Roger S. Chung, Emma Scotter, Leszek Lisowski, Mehdi Mirzaei, Adam K. Walker
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Understanding the mechanisms that drive TDP-43 pathology is integral to combating amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD) and other neurodegenerative diseases. Here we generated a longitudinal quantitati
Externí odkaz:
https://doaj.org/article/4c4d2aa5f2d24e1cbc0429058653faa3
Autor:
Molly E. V. Swanson, Miran Mrkela, Helen C. Murray, Maize C. Cao, Clinton Turner, Maurice A. Curtis, Richard L. M. Faull, Adam K. Walker, Emma L. Scotter
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-22 (2023)
Abstract Microglia, the innate immune cells of the brain, are activated by damage or disease. In mouse models of amyotrophic lateral sclerosis (ALS), microglia shift from neurotrophic to neurotoxic states with disease progression. It remains unclear
Externí odkaz:
https://doaj.org/article/ffaa51da88b7483d88b75ccc62336f16
Autor:
Taylor J. Stevenson, Rebecca H. Johnson, Jimmy Savistchenko, Justin Rustenhoven, Zoe Woolf, Leon C. D. Smyth, Helen C. Murray, Richard L. M. Faull, Jason Correia, Patrick Schweder, Peter Heppner, Clinton Turner, Ronald Melki, Birger V. Dieriks, Maurice A. Curtis, Michael Dragunow
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Parkinson’s disease (PD) is characterised by the progressive loss of midbrain dopaminergic neurons and the presence of aggregated α-synuclein (α-syn). Pericytes and microglia, two non-neuronal cells contain α-syn in the human brain, how
Externí odkaz:
https://doaj.org/article/0a4e76a833d74d76a95832207eacbaf4
Autor:
Leon C. D. Smyth, Blake Highet, Deidre Jansson, Jane Wu, Justin Rustenhoven, Miranda Aalderink, Adelie Tan, Susan Li, Rebecca Johnson, Natacha Coppieters, Renee Handley, Pritika Narayan, Malvindar K. Singh-Bains, Patrick Schweder, Clinton Turner, Edward W. Mee, Peter Heppner, Jason Correia, Thomas I.-H. Park, Maurice A. Curtis, Richard L. M. Faull, Mike Dragunow
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
Smyth et al. use tissue microarrays from Alzheimer’s disease (AD) patient brains to show that PDGF-BB:PDGFRβ signalling components are reduced in AD. They then use primary human brain pericytes to elucidate a pathway by which PDGF-BB:PDGFRβ signa
Externí odkaz:
https://doaj.org/article/ac4315ac00c245ed917bf0edddaef79a
Autor:
Leon C. D. Smyth, Helen C. Murray, Madison Hill, Eve van Leeuwen, Blake Highet, Nicholas J. Magon, Mahyar Osanlouy, Sophie N. Mathiesen, Bruce Mockett, Malvindar K. Singh-Bains, Vanessa K. Morris, Andrew N. Clarkson, Maurice A. Curtis, Wickliffe C. Abraham, Stephanie M. Hughes, Richard L. M. Faull, Anthony J. Kettle, Mike Dragunow, Mark B. Hampton
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-17 (2022)
Abstract Introduction Neutrophil accumulation is a well-established feature of Alzheimer’s disease (AD) and has been linked to cognitive impairment by modulating disease-relevant neuroinflammatory and vascular pathways. Neutrophils express high lev
Externí odkaz:
https://doaj.org/article/4881c6c2cd424db9be6a4d32261c425f
Autor:
Helen C. Murray, Kory Johnson, Andrea Sedlock, Blake Highet, Birger Victor Dieriks, Praju Vikas Anekal, Richard L. M. Faull, Maurice A. Curtis, Alan Koretsky, Dragan Maric
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Murray et al. present a multiplexed fluorescence-based immunohistochemistry approach and use it to screen up to 100 protein markers in the human olfactory bulb from neurologically healthy, Alzheimer’s, and Parkinson’s disease patients. In doing s
Externí odkaz:
https://doaj.org/article/4e92955a464b4b988c6b5cc67bfa5f33
Autor:
Amy M. Smith, Thomas In-Hyeup Park, Miranda Aalderink, Robyn L. Oldfield, Peter S. Bergin, Edward W. Mee, Richard L. M. Faull, Mike Dragunow
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
The study of microglia isolated from adult human brain tissue provides unique insight into the physiology of these brain immune cells and their role in adult human brain disorders. Reports of microglia in post-mortem adult human brain tissue show reg
Externí odkaz:
https://doaj.org/article/c5eff623830540a29eefa250fa8e6004
Autor:
Sarah Waters, Molly E. V. Swanson, Birger V. Dieriks, Yibin B. Zhang, Natasha L. Grimsey, Helen C. Murray, Clinton Turner, Henry J. Waldvogel, Richard L. M. Faull, Jiyan An, Robert Bowser, Maurice A. Curtis, Mike Dragunow, Emma Scotter
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-17 (2021)
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease involving progressive degeneration of upper and lower motor neurons. The pattern of lower motor neuron loss along the spinal cord follows the pattern of deposition of p
Externí odkaz:
https://doaj.org/article/075e0657417440b8988eb257ce9ef0e0
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 10, Pp 2197-2199 (2022)
Externí odkaz:
https://doaj.org/article/573d9301ed3b4a1db13b0273ef6f77b4