Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Richard L Klemke"'
Autor:
Megan Agajanian, Anaamika Campeau, Malachia Hoover, Alexander Hou, Daniel Brambilla, Sa La Kim, Richard L Klemke, Jonathan A Kelber
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135748 (2015)
Transforming Growth Factor β (TGFβ) has dual functions as both a tumor suppressor and a promoter of cancer progression within the tumor microenvironment, but the molecular mechanisms by which TGFβ signaling switches between these outcomes and the
Externí odkaz:
https://doaj.org/article/632f66d557f142b78bacd7f4bbb55c74
Autor:
Chad E Green, Tiffany Liu, Valerie Montel, Gene Hsiao, Robin D Lester, Shankar Subramaniam, Steven L Gonias, Richard L Klemke
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6713 (2009)
Tumor-associated macrophages are known to influence cancer progression by modulation of immune function, angiogenesis, and cell metastasis, however, little is known about the chemokine signaling networks that regulate this process. Utilizing CT26 col
Externí odkaz:
https://doaj.org/article/1e8f2788f7594012a58eff3e4da32646
Autor:
Richard L. Klemke, Kun-Liang Guan, Michael Bouvet, Jonathan Kelber, Jack Bui, Hyun Woo Park, Carlos Peinado, Emilie Gross, Tracy Wright, Meghan Wyse, Wei Zhang, Huawei Wang, Ken Fujimura, Sunkyu Choi, Jan Strnadel
Complete list of proteins identified in PEAK1-depleted PDAC cells by LC/MS/MS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3297786290e29a5818a9a0842c948766
https://doi.org/10.1158/0008-5472.22417248.v1
https://doi.org/10.1158/0008-5472.22417248.v1
Role of eIF5A and mTOR signaling in regulation of KRas protein expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a8c78e5c096ee394a258a8f78da3ac
https://doi.org/10.1158/0008-5472.22421648.v1
https://doi.org/10.1158/0008-5472.22421648.v1
Autor:
Richard L. Klemke, Kun-Liang Guan, Michael Bouvet, Jonathan Kelber, Jack Bui, Hyun Woo Park, Carlos Peinado, Emilie Gross, Tracy Wright, Meghan Wyse, Wei Zhang, Huawei Wang, Ken Fujimura, Sunkyu Choi, Jan Strnadel
Western blots showing PEAk1 and YAP1 depletion in PDAC cells treated with two independent shRNAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b0f445e75946f135bed5bdbe2a81297
https://doi.org/10.1158/0008-5472.22417251.v1
https://doi.org/10.1158/0008-5472.22417251.v1
Schematic of proposed working model for feedback regulation of KRas expression in PDAC cells by eIF5A-PEAK1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fd3a3051cab7a579069ca16824ed1f
https://doi.org/10.1158/0008-5472.22421633
https://doi.org/10.1158/0008-5472.22421633
Schematic showing hypusination of lysine 50 of eIF5A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff09c05e202c30bfefa733e902bfcd3
https://doi.org/10.1158/0008-5472.22421642.v1
https://doi.org/10.1158/0008-5472.22421642.v1
There remains intense interest in tractable approaches to target or silence the KRAS oncoprotein as a rational therapeutic strategy to attack pancreatic ductal adenocarcinoma (PDAC) and other cancers that overexpress it. Here we provide evidence that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::434a04c38b34f5bf3a016b4feb1fc09f
https://doi.org/10.1158/0008-5472.c.6510977.v1
https://doi.org/10.1158/0008-5472.c.6510977.v1
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d7b207d4d15df0cc34ada201d3c0eab
https://doi.org/10.1158/0008-5472.22421645
https://doi.org/10.1158/0008-5472.22421645
Pharmacological perturbation of glutamine metabolism and eIF5A inhibit cancer cell growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ed79e7a98f9ded08db698efa5e47a4
https://doi.org/10.1158/0008-5472.22421630.v1
https://doi.org/10.1158/0008-5472.22421630.v1