Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Richard L Frock"'
Autor:
Valeria Rangel, Jason N. Sterrenberg, Aya Garawi, Vyanka Mezcord, Melissa L. Folkerts, Sabrina E. Calderon, Yadhira E. Garcia, Jinglong Wang, Eli M. Soyfer, Oliver S. Eng, Jennifer B. Valerin, Sora Park Tanjasiri, Fabiola Quintero-Rivera, Marcus M. Seldin, Selma Masri, Richard L. Frock, Angela G. Fleischman, Nicholas R. Pannunzio
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Activation-induced cytidine deaminase (AID) is a B cell-specific mutator required for antibody diversification. However, it is also implicated in the etiology of several B cell malignancies. Evaluating the AID-induced mutation load in patien
Externí odkaz:
https://doaj.org/article/7199da5c9dc04e879f3964f64ebafee3
Autor:
Richard L Frock, Steven C Chen, Dao-Fu Da, Ellie Frett, Carmen Lau, Christina Brown, Diana N Pak, Yuexia Wang, Antoine Muchir, Howard J Worman, Luis F Santana, Warren C Ladiges, Peter S Rabinovitch, Brian K Kennedy
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42918 (2012)
Lmna(-/-) mice display multiple tissue defects and die by 6-8 weeks of age reportedly from dilated cardiomyopathy with associated conduction defects. We sought to determine whether restoration of lamin A in cardiomyocytes improves cardiac function an
Externí odkaz:
https://doaj.org/article/474b2d0db8044ac2a121f210bd305299
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10127 (2010)
Mutations in the LMNA gene, which encodes all A-type lamins, result in a variety of human diseases termed laminopathies. Lmna(-/-) mice appear normal at birth but become runted as early as 2 weeks of age and develop multiple tissue defects that mimic
Externí odkaz:
https://doaj.org/article/12b4a4da4a4c4832bea0f44d969598a9
Publikováno v:
Biomolecules, Vol 11, Iss 10, p 1487 (2021)
Humans have evolved a series of DNA double-strand break (DSB) repair pathways to efficiently and accurately rejoin nascently formed pairs of double-stranded DNA ends (DSEs). In G0/G1-phase cells, non-homologous end joining (NHEJ) and alternative end
Externí odkaz:
https://doaj.org/article/e30fa78c44c94aa39d9633e5ec469f02
Autor:
Paul G. Barghouth, Stavros Melemenidis, Pierre Montay-Gruel, Jonathan Ollivier, Vignesh Viswanathan, Patrik G. Jorge, Luis A. Soto, Brianna C. Lau, Cheyenne Sadeghi, Anushka Edlabadkar, Rakesh Manjappa, Jinghui Wang, Marie Le Bouteiller, Murat Surucu, Amy Yu, Karl Bush, Lawrie Skinner, Peter G. Maxim, Billy W. Loo, Charles L. Limoli, Marie-Catherine Vozenin, Richard L. Frock
Publikováno v:
bioRxiv
The molecular and cellular mechanisms driving the enhanced therapeutic ratio of ultra-high dose-rate radiotherapy (FLASH-RT) over slower conventional (CONV-RT) radiotherapy dose-rate remain to be elucidated. However, attenuated DNA damage and transie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6921f0ac02c46112a7921ab1b4d4c29e
https://doi.org/10.1101/2023.03.27.534408
https://doi.org/10.1101/2023.03.27.534408
Streptococcus pyogenesCRISPR-Cas9 (SpCas9) stabilizes each strand of a DNA bubble via distinct interactions, forming a stable ~20 bp R-loop on the complementary strand but relying on narrower protein-DNA interactions to bind the non-complementary str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::008c51286f2f93752874b7b67bc6ab0c
https://doi.org/10.1101/2022.11.08.515552
https://doi.org/10.1101/2022.11.08.515552
Autor:
Jin Liu, Manuel A F V Gonçalves, Richard L. Frock, Marie Le Bouteiller, Qian Wang, Josephine M. Janssen
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 49(2), 1173-1198. OXFORD UNIV PRESS
Nucleic Acids Research, 49(2), 1173-1198. OXFORD UNIV PRESS
RNA-guided nucleases (RGNs) based on CRISPR systems permit installing short and large edits within eukaryotic genomes. However, precise genome editing is often hindered due to nuclease off-target activities and the multiple-copy character of the vast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8abdc871f6974ca50abd72a4d87c1bbe
http://europepmc.org/articles/PMC7826261
http://europepmc.org/articles/PMC7826261
Autor:
Helen Segal, Sruthi Mantri, M. Kyle Cromer, Neehar Bhatia, Maria Grazia Roncarolo, Annalisa Lattanzi, Ciaran M. Lee, David DiGiusto, Rasmus O. Bak, Carsten T. Charlesworth, Josefin Kenrick, Jason Skowronski, Matthew H. Porteus, J. Fraser Wright, Richard L. Frock, Daniel P. Dever, Narae Talbott, Christopher A. Vakulskas, Joab Camarena, Gang Bao, Waracharee Srifa, Premanjali Lahiri, John F. Tisdale
Publikováno v:
Sci Transl Med
Lattanzi, A, Camarena, J, Lahiri, P, Segal, H, Srifa, W, Vakulskas, C A, Frock, R L, Kenrick, J, Lee, C, Talbott, N, Skowronski, J, Cromer, M K, Charlesworth, C T, Bak, R O, Mantri, S, Bao, G, DiGiusto, D, Tisdale, J, Wright, J F, Bhatia, N, Roncarolo, M G, Dever, D P & Porteus, M H 2021, ' Development of β-globin gene correction in human hematopoietic stem cells as a potential durable treatment for sickle cell disease ', Science Translational Medicine, vol. 13, no. 598, eabf2444 . https://doi.org/10.1126/scitranslmed.abf2444
Lattanzi, A, Camarena, J, Lahiri, P, Segal, H, Srifa, W, Vakulskas, C A, Frock, R L, Kenrick, J, Lee, C, Talbott, N, Skowronski, J, Cromer, M K, Charlesworth, C T, Bak, R O, Mantri, S, Bao, G, DiGiusto, D, Tisdale, J, Wright, J F, Bhatia, N, Roncarolo, M G, Dever, D P & Porteus, M H 2021, ' Development of β-globin gene correction in human hematopoietic stem cells as a potential durable treatment for sickle cell disease ', Science Translational Medicine, vol. 13, no. 598, eabf2444 . https://doi.org/10.1126/scitranslmed.abf2444
Sickle cell disease (SCD) is the most common monogenic serious disease with 300,000 births annually worldwide. SCD is autosomal recessive from a single point mutation in codon six of the β-globin gene (HBB) resulting in sickle hemoglobin. Ex vivo β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664c1c185e0b70b2cf6b0e1b79df95cb
https://doi.org/10.1126/scitranslmed.abf2444
https://doi.org/10.1126/scitranslmed.abf2444
Autor:
Richard L. Frock, Frederick W. Alt, Jeffrey Zurita, Vipul Kumar, Sherry G. Lin, Jiangman Lou, Josefin Kenrick, Cristian Boboila, Adam Yongxin Ye, Marie Le Bouteiller, Jianqiao Hu, Zhuoyi Liang
Publikováno v:
Proc Natl Acad Sci U S A
Classical nonhomologous end joining (C-NHEJ) repairs DNA double-strand breaks (DSBs) throughout interphase but predominates in G1 phase when homologous recombination is unavailable. Complexes containing the Ku70/80 (“Ku”) and XRCC4/ligase IV (Lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6075287bd3340bd8e7d039986af43f
https://doi.org/10.1073/pnas.2103630118
https://doi.org/10.1073/pnas.2103630118
Autor:
Qian Wang, Josephine M. Janssen, Marcella Brescia, Josefin Kenrick, Karoly Szuhai, Jin Liu, Francesca Tasca, Milena Bellin, Manuel A F V Gonçalves, Xiaoyu Chen, Richard L. Frock
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 48(2), 974-995. OXFORD UNIV PRESS
Nucleic Acids Research, 48(2), 974-995. OXFORD UNIV PRESS
Genome editing typically involves recombination between donor nucleic acids and acceptor genomic sequences subjected to double-stranded DNA breaks (DSBs) made by programmable nucleases (e.g. CRISPR–Cas9). Yet, nucleases yield off-target mutations a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa13d225f17fdf8a2fe15ab92de7d716
http://hdl.handle.net/11577/3321878
http://hdl.handle.net/11577/3321878