Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Richard L Elliott"'
Autor:
Bryan K. Chan, Eileen Seward, Michael Lainchbury, Thomas F. Brewer, Le An, Toby Blench, Matthew W. Cartwright, Grace Ka Yan Chan, Edna F. Choo, Jason Drummond, Richard L. Elliott, Emanuela Gancia, Lewis Gazzard, Baihua Hu, Graham E. Jones, Xifeng Luo, Andrew Madin, Sushant Malhotra, John G. Moffat, Jodie Pang, Laurent Salphati, Christopher J. Sneeringer, Craig E. Stivala, Binqing Wei, Weiru Wang, Ping Wu, Timothy P. Heffron
Publikováno v:
ACS Med Chem Lett
[Image: see text] Hematopoietic progenitor kinase 1 (HPK1) is implicated as a negative regulator of T-cell receptor-induced T-cell activation. Studies using HPK1 kinase-dead knock-in animals have demonstrated the loss of HPK1 kinase activity resulted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f11f71008647153e48985266e826374
https://doi.org/10.1021/acsmedchemlett.1c00473
https://doi.org/10.1021/acsmedchemlett.1c00473
Autor:
Melody L, Bowen, Richard L, Elliott
Publikováno v:
Journal of the Medical Association of Georgia. 105(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9a371ed841cc09b2248771bcaa3c212b
https://pubmed.ncbi.nlm.nih.gov/30251775
https://pubmed.ncbi.nlm.nih.gov/30251775
Publikováno v:
Journal of the Medical Association of Georgia. 106(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e1b92a07644b962bc47a244ffefdf944
https://pubmed.ncbi.nlm.nih.gov/30251781
https://pubmed.ncbi.nlm.nih.gov/30251781
Publikováno v:
Journal of the Medical Association of Georgia. 105(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1e0b8501b44b827787fc3c9d2fa1b342
https://pubmed.ncbi.nlm.nih.gov/29813196
https://pubmed.ncbi.nlm.nih.gov/29813196
Autor:
Laura, Lowrey, Richard L, Elliott
Publikováno v:
Journal of the Medical Association of Georgia. 105(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fbffd0fe63cb31ac79bc0910b45cb575
https://pubmed.ncbi.nlm.nih.gov/29809346
https://pubmed.ncbi.nlm.nih.gov/29809346
Autor:
Laurent Salphati, Daniel P. Sutherlin, Binqing Wei, Jim Nonomiya, Brian Safina, Richard L. Elliott, Jodie Pang, Robert Heald, Eileen Mary Seward, Mark Ultsch, Jeremy Murray, Wenqian Yang, Andrew Keith Harlow Forrest, Steven T. Staben
Publikováno v:
ACS medicinal chemistry letters. 8(9)
A novel selective benzoxazepin inhibitor of PI3Kδ has been discovered. Beginning from compound 3, an αPI3K inhibitor, we utilized structure-based drug design and computational analysis of dihedral torsion angles to optimize for PI3Kδ isoform poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e416623d1c12d4b79901a84c2f7037
https://pubmed.ncbi.nlm.nih.gov/28947940
https://pubmed.ncbi.nlm.nih.gov/28947940
Publikováno v:
The American Surgeon. 81:544-546
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9f3b3836db34fc1e53935a9390f7f6c
https://doi.org/10.1177/000313481508100541
https://doi.org/10.1177/000313481508100541
Autor:
Charles Eigenbrot, Robert Heald, Bryan K. Chan, Michael D. Lainchbury, Timothy P. Heffron, Hans E. Purkey, Hank La, Philip Stephen Jackson, Stephen P. Schmidt, Gabriele Schaefer, Emily Chan, Marian C. Bryan, Ivana Yen, Jamie D. Knight, Daniel J. Burdick, Yuan Chen, Lily Shao, Richard L. Elliott, Jennafer Dotson, Shiva Malek, Christine Yu, Krista K. Bowman, Steve Sideris, Hanan Emily, Shumei Wang, Saundra Clausen, Siew Kuen Yeap, Eileen Mary Seward, Trisha Dela Vega
Publikováno v:
Journal of medicinal chemistry. 59(19)
Inhibitors targeting the activating mutants of the epidermal growth factor receptor (EGFR) have found success in the treatment of EGFR mutant positive non-small-cell lung cancer. A secondary point mutation (T790M) in the inhibitor binding site has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4580624912774874fa97c4be36fcef
https://pubmed.ncbi.nlm.nih.gov/27564586
https://pubmed.ncbi.nlm.nih.gov/27564586
Autor:
Patricia, Tran, Richard L, Elliott
Publikováno v:
Journal of the Medical Association of Georgia. 105(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::18f770b126d532ea16ee7a386d5a9524
https://pubmed.ncbi.nlm.nih.gov/27209675
https://pubmed.ncbi.nlm.nih.gov/27209675
Autor:
Melissa L. Gillaspy, Diane M. Hargrove, Mary E. Lame, Paul Da Silva Jardine, Dennis O. Scott, Catherine E. Trebino, Yingxin Zhang, Kimberly O. Cameron, Richard L. Elliott, Kelly A. Martin, Janice E. Chin, Elena E. Beretta, Swick Andrew Gordon, Jeffrey S. Dubins, Janet A. LaFlamme, Dexue Sun, Tristan S. Maurer, Nancy A. Nardone, Amit S. Kalgutkar, Jeremy A. Bartlett, Robert M. Oliver, Yue Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6797-6801
We describe the design, synthesis, and structure-activity relationships of triazolobenzodiazepinone CCK1 receptor agonists. Analogs in this series demonstrate potent agonist activity as measured by in vitro and in vivo assays for CCK1 agonism. Our ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeaaaf4e60123f7f9fd8e609d714c16d
https://doi.org/10.1016/j.bmcl.2010.08.115
https://doi.org/10.1016/j.bmcl.2010.08.115