Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Richard Klar"'
Autor:
Alfred Zippelius, Mélanie Buchi, Richard Klar, Julia Festag, Monika Schell, Sven Michel, Frank Jaschinski, Nicole Kirchhammer, Andre Maaske, Laura Fernandez Rodriguez, Stefanie Raith
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/8d9deaf4680c4b0188ce465ba98d44a2
Autor:
Alfred Zippelius, Mélanie Buchi, Richard Klar, Julia Festag, Sven Michel, Frank Jaschinski, Sebastian Kobold, Abhishek S Kashyap, Johannes vom Berg, Laura Fernandez-Rodriguez, Chiara Cianciaruso, Ruben Bill, Marcel P Trefny, Nicole Kirchhammer, Rainer H Kohler, Elham Jones, Andre Maaske, Karen O Dixon, Mikael J Pittet
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)
Background Although immune checkpoint inhibitors have been a breakthrough in clinical oncology, these therapies fail to produce durable responses in a significant fraction of patients. This lack of long-term efficacy may be due to a poor pre-existing
Externí odkaz:
https://doaj.org/article/78cf6c8515374d7f847b8913a986bde6
Autor:
Julia Festag, Tamara Thelemann, Monika Schell, Stefanie Raith, Sven Michel, Frank Jaschinski, Richard Klar
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 21, Iss , Pp 656-669 (2020)
The adenosine axis contributes to the suppression of antitumor immune responses. The ectonucleotidase CD39 degrades extracellular adenosine triphosphate (ATP) to adenosine monophosphate (AMP), which is degraded to adenosine by CD73. Adenosine binds t
Externí odkaz:
https://doaj.org/article/42e8450dd8f7414f8e521a6e5f56c509
Autor:
Anne Sadewasser, Erik Dietzel, Sven Michel, Michael Klüver, Markus Helfer, Tamara Thelemann, Richard Klar, Markus Eickmann, Stephan Becker, Frank Jaschinski
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 16, Iss , Pp 686-697 (2019)
Ebola virus is the causative agent of Ebola virus disease, a severe, often fatal illness in humans. So far, there are no US Food and Drug Administration (FDA)-approved therapeutics directed against Ebola virus. Here, we selected the host factor Niema
Externí odkaz:
https://doaj.org/article/308c7be2e7a44d74b79da85945b8925c
Autor:
Yu Cao, Jimena Trillo-Tinoco, Rosa A. Sierra, Carmen Anadon, Wenjie Dai, Eslam Mohamed, Ling Cen, Tara L. Costich, Anthony Magliocco, Douglas Marchion, Richard Klar, Sven Michel, Frank Jaschinski, Richard R. Reich, Shikhar Mehrotra, Juan R. Cubillos-Ruiz, David H. Munn, Jose R. Conejo-Garcia, Paulo C. Rodriguez
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
T-cell function impairment is one of the major determinants of tumour immune evasion. Here, the authors show that the hostile conditions in the tumour microenvironment lead to C/EBP homologous-protein upregulation in T cells via ER stress, resulting
Externí odkaz:
https://doaj.org/article/f05c7d9780cc4100b5638fc324c1bb21
Autor:
Abhishek S. Kashyap, Tamara Thelemann, Richard Klar, Sandra M. Kallert, Julia Festag, Melanie Buchi, Lisa Hinterwimmer, Monika Schell, Sven Michel, Frank Jaschinski, Alfred Zippelius
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-12 (2019)
Abstract Background Cancer cells are known to develop mechanisms to circumvent effective anti-tumor immunity. The two ectonucleotidases CD39 and CD73 are promising drug targets, as they act in concert to convert extracellular immune-stimulating ATP t
Externí odkaz:
https://doaj.org/article/270e5351314041b4b9b45ed11b5860ce
Autor:
Stefan Audehm, Manuel Glaser, Matteo Pecoraro, Eva Bräunlein, Sabine Mall, Richard Klar, Manuel Effenberger, Julian Albers, Henrique de Oliveira Bianchi, Janet Peper, Nahid Yusufi, Dirk H. Busch, Stefan Stevanović, Matthias Mann, Iris Antes, Angela M. Krackhardt
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Adoptive transfer of T cells transgenic for tumor-reactive T-cell receptors (TCR) is an attractive immunotherapeutic approach. However, clinical translation is so far limited due to challenges in the identification of suitable target antigens as well
Externí odkaz:
https://doaj.org/article/22a2a126e49249719ac2dc109a786b0d
Autor:
Michal Bassani-Sternberg, Eva Bräunlein, Richard Klar, Thomas Engleitner, Pavel Sinitcyn, Stefan Audehm, Melanie Straub, Julia Weber, Julia Slotta-Huspenina, Katja Specht, Marc E. Martignoni, Angelika Werner, Rüdiger Hein, Dirk H. Busch, Christian Peschel, Roland Rad, Jürgen Cox, Matthias Mann, Angela M. Krackhardt
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Neoantigens determine anti-cancer immunoreactivity and are important functional targets for immunotherapy. Here, the authors use deep mass spectrometry to characterize neoepitopes from human melanoma tissue and show the presence of tumour-reactive T
Externí odkaz:
https://doaj.org/article/9d43ba6c8b234b1ab6f92d398fb3a892
Autor:
Yu Cao, Jimena Trillo-Tinoco, Rosa A. Sierra, Carmen Anadon, Wenjie Dai, Eslam Mohamed, Ling Cen, Tara L. Costich, Anthony Magliocco, Douglas Marchion, Richard Klar, Sven Michel, Frank Jaschinski, Richard R. Reich, Shikhar Mehrotra, Juan R. Cubillos-Ruiz, David H. Munn, Jose R. Conejo-Garcia, Paulo C. Rodriguez
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/abe981cf7a3943d19915317c7bf25947
Autor:
Benedikt Kaufmann, Marta de Los Reyes Jiménez, Laela M. Booshehri, Janset Onyuru, Aleksandra Leszczynska, Anna Uri, Sven Michel, Richard Klar, Frank Jaschinski, Ariel E. Feldstein, Lori Broderick, Hal M. Hoffman
Publikováno v:
The Journal of Immunology.
Antisense oligonucleotides (ASOs) are a novel therapeutic strategy that targets a specific gene and suppresses its expression. The cryopyrin-associated periodic syndromes (CAPS) are a spectrum of autoinflammatory diseases characterized by systemic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14f95f169f17dde312d4ad3a18043bec
https://doi.org/10.4049/jimmunol.2200550
https://doi.org/10.4049/jimmunol.2200550