Výsledky vyhledávání - "Richard Klar"

Akademický článek

Dual TLR9 and PD-L1 targeting unleashes dendritic cells to induce durable antitumor immunity

Autor: Alfred Zippelius, Mélanie Buchi, Richard Klar, Julia Festag, Sven Michel, Frank Jaschinski, Sebastian Kobold, Abhishek S Kashyap, Johannes vom Berg, Laura Fernandez-Rodriguez, Chiara Cianciaruso, Ruben Bill, Marcel P Trefny, Nicole Kirchhammer, Rainer H Kohler, Elham Jones, Andre Maaske, Karen O Dixon, Mikael J Pittet

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)

Background Although immune checkpoint inhibitors have been a breakthrough in clinical oncology, these therapies fail to produce durable responses in a significant fraction of patients. This lack of long-term efficacy may be due to a poor pre-existing

Externí odkaz: https://doaj.org/article/78cf6c8515374d7f847b8913a986bde6

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Akademický článek

Preventing ATP Degradation by ASO-Mediated Knockdown of CD39 and CD73 Results in A2aR-Independent Rescue of T Cell Proliferation

Autor: Julia Festag, Tamara Thelemann, Monika Schell, Stefanie Raith, Sven Michel, Frank Jaschinski, Richard Klar

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 21, Iss , Pp 656-669 (2020)

The adenosine axis contributes to the suppression of antitumor immune responses. The ectonucleotidase CD39 degrades extracellular adenosine triphosphate (ATP) to adenosine monophosphate (AMP), which is degraded to adenosine by CD73. Adenosine binds t

Externí odkaz: https://doaj.org/article/42e8450dd8f7414f8e521a6e5f56c509

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Akademický článek

Anti-Niemann Pick C1 Single-Stranded Oligonucleotides with Locked Nucleic Acids Potently Reduce Ebola Virus Infection In Vitro

Autor: Anne Sadewasser, Erik Dietzel, Sven Michel, Michael Klüver, Markus Helfer, Tamara Thelemann, Richard Klar, Markus Eickmann, Stephan Becker, Frank Jaschinski

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 16, Iss , Pp 686-697 (2019)

Ebola virus is the causative agent of Ebola virus disease, a severe, often fatal illness in humans. So far, there are no US Food and Drug Administration (FDA)-approved therapeutics directed against Ebola virus. Here, we selected the host factor Niema

Externí odkaz: https://doaj.org/article/308c7be2e7a44d74b79da85945b8925c

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Akademický článek

ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression

Autor: Yu Cao, Jimena Trillo-Tinoco, Rosa A. Sierra, Carmen Anadon, Wenjie Dai, Eslam Mohamed, Ling Cen, Tara L. Costich, Anthony Magliocco, Douglas Marchion, Richard Klar, Sven Michel, Frank Jaschinski, Richard R. Reich, Shikhar Mehrotra, Juan R. Cubillos-Ruiz, David H. Munn, Jose R. Conejo-Garcia, Paulo C. Rodriguez

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

T-cell function impairment is one of the major determinants of tumour immune evasion. Here, the authors show that the hostile conditions in the tumour microenvironment lead to C/EBP homologous-protein upregulation in T cells via ER stress, resulting

Externí odkaz: https://doaj.org/article/f05c7d9780cc4100b5638fc324c1bb21

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Akademický článek

Antisense oligonucleotide targeting CD39 improves anti-tumor T cell immunity

Autor: Abhishek S. Kashyap, Tamara Thelemann, Richard Klar, Sandra M. Kallert, Julia Festag, Melanie Buchi, Lisa Hinterwimmer, Monika Schell, Sven Michel, Frank Jaschinski, Alfred Zippelius

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-12 (2019)

Abstract Background Cancer cells are known to develop mechanisms to circumvent effective anti-tumor immunity. The two ectonucleotidases CD39 and CD73 are promising drug targets, as they act in concert to convert extracellular immune-stimulating ATP t

Externí odkaz: https://doaj.org/article/270e5351314041b4b9b45ed11b5860ce

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Akademický článek

Key Features Relevant to Select Antigens and TCR From the MHC-Mismatched Repertoire to Treat Cancer

Autor: Stefan Audehm, Manuel Glaser, Matteo Pecoraro, Eva Bräunlein, Sabine Mall, Richard Klar, Manuel Effenberger, Julian Albers, Henrique de Oliveira Bianchi, Janet Peper, Nahid Yusufi, Dirk H. Busch, Stefan Stevanović, Matthias Mann, Iris Antes, Angela M. Krackhardt

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Adoptive transfer of T cells transgenic for tumor-reactive T-cell receptors (TCR) is an attractive immunotherapeutic approach. However, clinical translation is so far limited due to challenges in the identification of suitable target antigens as well

Externí odkaz: https://doaj.org/article/22a2a126e49249719ac2dc109a786b0d

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Antisense Oligonucleotide Therapy Decreases IL-1β Expression and Prolongs Survival in Mutant Nlrp3 Mice

Autor: Benedikt Kaufmann, Marta de Los Reyes Jiménez, Laela M. Booshehri, Janset Onyuru, Aleksandra Leszczynska, Anna Uri, Sven Michel, Richard Klar, Frank Jaschinski, Ariel E. Feldstein, Lori Broderick, Hal M. Hoffman

Publikováno v: The Journal of Immunology.

Antisense oligonucleotides (ASOs) are a novel therapeutic strategy that targets a specific gene and suppresses its expression. The cryopyrin-associated periodic syndromes (CAPS) are a spectrum of autoinflammatory diseases characterized by systemic an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14f95f169f17dde312d4ad3a18043bec
https://doi.org/10.4049/jimmunol.2200550

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