Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Richard Kil"'
Autor:
Criselda Jean G. Cruz, Richard Kil, Stanley Wong, Louis C. Dacquay, Denise Mirano-Bascos, Pilarita T. Rivera, David R. McMillen
Publikováno v:
ACS Synthetic Biology. 11:2938-2946
Malaria, a disease caused by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463f3ab170bc25c0423e6d88b23fe1ee
https://doi.org/10.1021/acssynbio.2c00160
https://doi.org/10.1021/acssynbio.2c00160
Autor:
Erwin Lemche, Richard Killick, Jackie Mitchell, Paul W. Caton, Pratik Choudhary, Jane K. Howard
Publikováno v:
Neurobiology of Disease, Vol 196, Iss , Pp 106485- (2024)
Research evidence indicating common metabolic mechanisms through which type 2 diabetes mellitus (T2DM) increases risk of late-onset Alzheimer's dementia (LOAD) has accumulated over recent decades. The aim of this systematic review is to provide a com
Externí odkaz:
https://doaj.org/article/c3c280316f034a86a4c98744d78acff2
Autor:
Roberto Collu, Zheng Yin, Elisa Giunti, Sarah Daley, Mei Chen, Peter Morin, Richard Killick, Stephen T. C. Wong, Weiming Xia
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
IntroductionThe goal of this study is to explore the pharmacological potential of the amyloid-reducing vasodilator fasudil, a selective Ras homolog (Rho)-associated kinases (ROCK) inhibitor, in the P301S tau transgenic mouse model (Line PS19) of neur
Externí odkaz:
https://doaj.org/article/738526ed29cf4602848657bb379d4868
Autor:
Ayesha Khan, Richard Killick, Daniel Wirth, Dominique Hoogland, Kalina Hristova, Jakob P. Ulmschneider, Christopher R. King, Martin B. Ulmschneider
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 9, Iss 4, Pp n/a-n/a (2023)
Abstract Introduction Reducing brain levels of both soluble and insoluble forms of amyloid beta (Aβ) remains the primary goal of most therapies that target Alzheimer's disease (AD). However, no treatment has so far resulted in patient benefit, and c
Externí odkaz:
https://doaj.org/article/964ff61904ec4b6b91c1f1f545a124ba
Publikováno v:
ACS Synthetic Biology
Synthetic biology may be viewed as an effort to establish, formalize, and develop an engineering discipline in the context of biological systems. The ability to tune the properties of individual components is central to the process of system design i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16c85450a2d6a361480ef1dbca0429f
https://doi.org/10.1021/sb4000564
https://doi.org/10.1021/sb4000564
Autor:
Khadijeh Ghasemian, Inge Broer, Jennifer Schön, Nadine Kolp, Richard Killisch, Stefan Mikkat, Jana Huckauf
Publikováno v:
Frontiers in Plant Science, Vol 14 (2023)
Rodent population control through contraception requires species-specific oral contraceptive vaccines. Therefore, in this study, we produced putative mouse-specific contraceptive peptides, mZP2 (from oocyte) and mIzumo1 (from sperm), in plants using
Externí odkaz:
https://doaj.org/article/8a2166d0da9e431ab8506c96c47e3d9d
Autor:
Richard Killick, Christina Elliott, Elena Ribe, Martin Broadstock, Clive Ballard, Dag Aarsland, Gareth Williams
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 11219 (2023)
The pan Rho-associated coiled-coil-containing protein kinase (ROCK) inhibitor fasudil acts as a vasodilator and has been used as a medication for post-cerebral stroke for the past 29 years in Japan and China. More recently, based on the involvement o
Externí odkaz:
https://doaj.org/article/6ef281694b6e49188979fd046f1e6899
Autor:
Eugene Kim, Davide Di Censo, Mattia Baraldo, Camilla Simmons, Ilaria Rosa, Karen Randall, Clive Ballard, Ben R. Dickie, Steven C. R. Williams, Richard Killick, Diana Cash
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Amyloid plaques are a hallmark of Alzheimer’s disease (AD) that develop in its earliest stages. Thus, non-invasive detection of these plaques would be invaluable for diagnosis and the development and monitoring of treatments, but this rema
Externí odkaz:
https://doaj.org/article/df2aaa01f2f84dd0ac1f44193b0b4812
Autor:
Khadijeh Ghasemian, Inge Broer, Jennifer Schön, Richard Killisch, Nadine Kolp, Armin Springer, Jana Huckauf
Publikováno v:
Vaccines, Vol 11, Iss 2, p 462 (2023)
A short mouse-specific peptide from zona pellucida 3 (mZP3, amino acids 328–342) has been shown to be associated with antibody-mediated contraception. In this study, we investigated the production of mZP3 in the plant, as an orally applicable host,
Externí odkaz:
https://doaj.org/article/85a8b53ad9f04212b5cec86f543417b9
Publikováno v:
Vaccines, Vol 11, Iss 1, p 153 (2023)
Contraceptive vaccines are designed to stimulate autoimmune responses to molecules involved in the reproductive process. A mouse-specific peptide from zona pellucida 3 (mZP3) has been proposed as a target epitope. Here, we employed a plant expression
Externí odkaz:
https://doaj.org/article/e39d6066591a4b0f993527ec71732ca5