Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Richard Kennan"'
Publikováno v:
Frontiers in Physics, Vol 5 (2017)
Introduction: Glycogen is the primary intracellular storage form of carbohydrates. In contrast to most tissues where stored glycogen can only supply the local tissue with energy, hepatic glycogen is mobilized and released into the blood to maintain a
Externí odkaz:
https://doaj.org/article/8ee676222f544290b6ebdd1c9fbd469e
Autor:
Caryn Hampton, Raymond Rosa, Daphne Szeto, Gail Forrest, Barry Campbell, Richard Kennan, Shubing Wang, Chin-Hu Huang, Loise Gichuru, Xiaoli Ping, Xiaolan Shen, Kersten Small, Jeffrey Madwed, Joseph J Lynch
Publikováno v:
SAGE Open Medicine, Vol 5 (2017)
Introduction: Despite the widespread use of the mouse transverse aortic constriction heart failure model, there are no reports on the characterization of the standard-of-care agent carvedilol in this model. Methods: Left ventricular pressure overload
Externí odkaz:
https://doaj.org/article/f63b2f7ff471419f8b3ad093784171db
Autor:
Kenneth K. Tanabe, Jayashree Kalpathy-Cramer, Michelle Bunzel, Kailyn Looby, Christian T. Farrar, Eric M. Gale, Peter Caravan, Yonghua Zhu, Valerie Humblet, Michael Klimas, Shirly Pinto, Chunlian Zhang, Lan Wei, Richard Kennan, Bryan C. Fuchs, Ricard Masia, Ian Ramsay, Himashinie V. K. Diyabalanage, Gunisha Arora, Taro E. Akiyama
Publikováno v:
Radiology. 287:581-589
Purpose To evaluate the biodistribution, metabolism, and pharmacokinetics of a new type I collagen-targeted magnetic resonance (MR) probe, CM-101, and to assess its ability to help quantify liver fibrosis in animal models. Materials and Methods Biodi
Autor:
Kersten M. Small, Caryn Hampton, Loise Gichuru, Joseph J. Lynch, Xiaoli Ping, Ray Rosa, Richard Kennan, Jeffrey B. Madwed, Xiaolan Shen, Barry R. Campbell
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 84:93-101
Introduction Mouse transverse aortic constriction (TAC) is a widely-used model of pressure overload-induced heart failure. An intrinsic limitation of the model is variability in the response to pressure overload even when employing a standard severit
Autor:
John C. Gore, Jin Cao, Li Min Chen, Richard Kennan, Corin O. Miller, George H. Wilson, He Zhu
Publikováno v:
Frontiers in Physics, Vol 5 (2017)
Introduction: Glycogen is the primary intracellular storage form of carbohydrates. In contrast to most tissues where stored glycogen can only supply the local tissue with energy, hepatic glycogen is mobilized and released into the blood to maintain a
Autor:
Vincenzo Pucci, Amy Vanko, Christopher Ware, Weisheng Zhang, Johnny E. Kopinja, Peter Spacciapoli, Lata Jayaraman, Richard Kennan, Michael H. Lam, David Dai, Diane Levitan, Christian Fischer, Kun Hu, Astrid M. Kral, Edward Spooner, Raquel S. Sevilla, Robert Forget, Samanthi A. Perera
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Mutations in IDH1 are highly prevalent in human glioma. First line treatment is radiotherapy, which many patients often forego to avoid treatment-associated morbidities. The high prevalence of IDH1 mutations in glioma highlights the need for brain-pe
Autor:
Valdeci Da Cunha, Kersten M. Small, Shu-Yu Sun, Xiaoli Ping, Liming Yang, Xiaolan Shen, Barry R. Campbell, Shuqin Zheng, Xuening Hong, Huawei Zhao, Chin-hu Huang, Richard Kennan, Jeffrey Madwed
Publikováno v:
Circulation Research. 119
The absence of animal models displaying clinical phenotypes of HFpEF represents a challenge to the pharmaceutical industry in the hope of identifying novel treatments that would benefit patients with this syndrome. We, at Merck, examined the supracor
Autor:
Kersten M. Small, Johnson Jeffrey Charles, Xuening Hong, Richard Kennan, Shu-Yu Sun, Valdeci Da Cunha, Jeffrey Madwed, Huawei Zhao, Xiaoli Ping, Leslawa Zwiercan, Chunlian Zhang, Xiaolan Shen, Chin-hu Huang
Publikováno v:
Journal of Cardiac Failure. 22:S39
Publikováno v:
ASME 2010 Summer Bioengineering Conference, Parts A and B.
High-resolution Magnetic Resonance Imaging (MRI) of humans and animals in vivo is routine and non-invasive. Identifying and quantifying chemical composition of tissue from acquired images is a challenge. MR spectroscopy (MRS) may be used to identify
Publikováno v:
Journal of magnetic resonance imaging : JMRI. 26(4)
Purpose: To implement and evaluate the gradient reversalbased chemical shift imaging technique to obtain qualitative and quantitative spatially-registered fat and water images with high imaging efficiency at very high field. Materials and Methods: A