Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Richard K. Stewart"'
The Intravascular Persistence and Methemoglobin Formation of Hemolink™ (Hemoglobin Raffimer) in Dogs
Publikováno v:
Artificial Cells, Blood Substitutes, and Biotechnology. 31:1-17
Hemoglobin raffimer (HEMOLINK, Hemosol Inc, Mississauga, Canada) is an o-raffinose cross-linked, purified human hemoglobin-based oxygen therapeutic that is currently being evaluated in late stage clinical trials. It is composed of several molecular w
Publikováno v:
Carcinogenesis. 19:275-280
The association between glutathione S-transferase (GST) activity as measured by 1-chloro-2,4-dinitrobenzene (CDNB) conjugation and genotype at exon 5 and exon 6 of the human GSTP1 gene was investigated in normal lung tissue obtained from 34 surgical
Publikováno v:
Molecular Pharmacology. 51:1034-1041
Glutathione-S-transferase-catalyzed conjugation of glutathione (GSH) to aflatoxin B1-8,9-epoxide plays an important role in preventing binding of this ultimate carcinogen to target macromolecules. Once formed, the aflatoxin B1-epoxide-GSH conjugates
Publikováno v:
Archives of Toxicology. 71:72-79
The cytotoxic and carcinogenic mycotoxin aflatoxin (AF) B1 (AFB1) is biotransformed by the cytochrome P450 monooxygenases (CYP) to a number of relatively nontoxic metabolites, as well as to the ultimate toxic metabolite, AFB1-8,9-epoxide. In a number
Autor:
Richard K. Stewart, A.Alan Conlan, Thomas E. Massey, Patty J. Donnelly, Dimitri Petsikas, Sophia L. Ali, Ken R. Reid
Publikováno v:
Carcinogenesis. 17:2487-2494
2Surgery, and 'Medicine, Queen's University, Kingston, ON, Canada, K7L 3N6 ''To whom correspondence should be addressed In addition to being a potent hepatocarcinogen, aflatoxin Bi (AFBi) is a pulmonary carcinogen in experimental animals, and epidemi
Publikováno v:
Experimental Biology and Medicine. 208:213-227
Aflatoxin B1 (AFB1) is a fungal toxin that has been implicated as a causative agent in human hepatic and extrahepatic carcinogenesis. In this review, the mechanisms involved in AFB1 toxicity are delineated, in order to describe the features that make
Publikováno v:
Carcinogenesis. 11:823-827
Aflatoxin B1 (AFB1) is a potent hepatotoxic and hepatocarcinogenic mycotoxin that requires bioactivation to AFB1-2,3-oxide for activity. In addition to epoxidation, microsomal monooxygenases biotransform AFB1 to the less toxic metabolites, aflatoxin
Publikováno v:
Carcinogenesis. 11:1915-1919
In order to study the mechanism of cancer production by aflatoxin B1 (AFB1) in extrahepatic tissues which have relatively low cytochrome P450 monooxygenase (P450) activity, we have examined prostaglandin H synthase (PHS)-mediated AFB1 activation [( 3
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 68(1)
Bisphenol A (BPA) is a weak estrogenic compound mass-produced with potential human exposure. Following a single oral or intravenous (iv) dose of 100 μg/kg [ring- 14 C(U)] radiolabeled bisphenol A ( 14 C-BPA) to male and female cynomolgus monkeys, 79
Autor:
Ken R. Reid, Graeme B. J. Smith, Richard K. Stewart, Patty J. Donnelly, A.Alan Conlan, Dimitri Petsikas, Thomas E. Massey
Publikováno v:
Carcinogenesis. 20(10)
Epidemiological studies suggest that aflatoxin B(1) (AFB(1)), a mycotoxin produced by certain Aspergillus species, may play a role in human respiratory cancers in occupationally-exposed individuals. AFB(1) requires bioactivation to the corresponding