Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Richard K. Bruick"'
Autor:
Haruhiko Sakiyama, Tomomi Takeshima, Hanzhi Wang, Shuguang Wei, R. Max Wynn, Hunmin Jung, Bruce A. Posner, Kosaku Uyeda, Richard K. Bruick, Tsutomu Nakagawa, Yang Li, Jef K. De Brabander, Karen S. MacMillan
Publikováno v:
Biochemical Journal
The carbohydrate response element binding protein (ChREBP) is a glucose-responsive transcription factor that plays a critical role in glucose-mediated induction of genes involved in hepatic glycolysis and lipogenesis. In response to fluctuating blood
Publikováno v:
Proceedings of the National Academy of Sciences. 115:13240-13245
Hypoxia-inducible factors (HIFs) are transcription factors in the basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) protein family that contain internal hydrophobic cavities within their PAS-A and PAS-B domains. Among HIFs, the HIF-2α PAS-B domain cont
Autor:
Raffi Bekeredjian, Chad B Walton, Keith A MacCannell, Jennifer Ecker, Fred Kruse, Joel T Outten, David Sutcliffe, Robert D Gerard, Richard K Bruick, Ralph V Shohet
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11693 (2010)
The response to hypoxia in tissues is regulated by the heterodimeric transcription factor Hypoxia Inducible Factor-1 (HIF-1).We have created a strain of mice with inducible cardiomyocyte-specific expression of a mutated, oxygen-stable, form of HIF-1a
Externí odkaz:
https://doaj.org/article/ddb8e55358564cacb40386e4a6b5b22b
Autor:
Emma J. Hodson, Alana Burrell, James W. Fielding, Luise Eckardt, Maria Prange-Barczynska, Xiaotong Cheng, Peter A. Robbins, Richard K. Bruick, Christopher W. Pugh, Isobel L.A. Argles, Keith J. Buckler, Lucy M. Collinson, Fraydoon Rastinejad, Tammie Bishop, Peter J. Ratcliffe, Minghao Zhang, Joanna Darck Carola Correia Lima
Publikováno v:
The Journal of Clinical Investigation
Hypoxia-inducible factor (HIF) is strikingly upregulated in many types of cancer and there is great interest in applying inhibitors of HIF as anti-cancer therapeutics. The most advanced of these are small molecules that target the HIF-2 isoform throu
Autor:
Max Hendrix, William K. Cornwell, Benjamin D. Levine, Satyam Sarma, Hannes Gatterer, Justin S. Lawley, Mario Thevis, Erin J. Howden, Katrin A. Dias, Mitchel Samels, Christopher M. Hearon, Richard K. Bruick, Braden Everding, Thomas Piper
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 127(6)
This study aimed to quantify the sedative effects, detection rates, and cardiovascular responses to xenon. On 3 occasions, participants breathed xenon (FiXe 30% for 20 min; FiXe 50% for 5 min; FiXe 70% for 2 min) in a nonblinded design. Sedation was
Autor:
Mario Thevis, Satyam Sarma, Justin S. Lawley, Braden Everding, Erin J. Howden, Allan Shuo-Wen Liang, Christopher M. Hearon, Max Hendrix, Mitchel Samels, Thomas Piper, William K. Cornwell rd, Richard K. Bruick, Katrin A. Dias, Hannes Gatterer, Benjamin D. Levine
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 127(6)
This study aimed to assess the efficacy of acute subanesthetic dosages of xenon inhalation to cause erythropoiesis and determine the effect of chronic xenon dosing on hematological parameters and athletic performance. To assess the acute effects, sev
Autor:
Daisha J. Cipher, Uttam K. Tambar, Chunhua Yu, Agoston T. Agoston, Richard K. Bruick, Xiaofang Huo, Stuart J. Spechler, Robert D. Odze, Xi Zhang, Kerry E Dunbar, Edaire Cheng, Qiuyang Zhang, David H. Wang, Thai H. Pham, Rhonda F. Souza
Publikováno v:
Gut. 66:1542-1554
Objective In an earlier study wherein we induced acute reflux by interrupting proton pump inhibitor (PPI) therapy in patients with reflux oesophagitis (RO) healed by PPIs, we refuted the traditional concept that RO develops as an acid burn. The prese
Autor:
Paul Yell, Farrah Homayoun, Xiankai Sun, Ivan Pedrosa, Naseem J. Zojwalla, Tae Hyun Hwang, Andrea Pavia-Jimenez, Wallace Eli M, Tai Wong, Wenfang Chen, Allison Joyce, Nirav V. Patel, Renée M. McKay, Xian Jin Xie, James Brugarolas, Kevin D. Courtney, James P. Rizzi, Payal Kapur, Kevin H. Gardner, Eboni Holloman, Haley Hill, Min Kim, Richard K. Bruick, John A. Josey, Alana Christie, Jenny Chang, He Zhang, Eugene P. Frenkel, Yuanqing Ma, Heather Geiger, Guiyang Hao, Yang Xie, Qurratulain Yousuf, Catherine Reeves
Publikováno v:
Nature. 539:112-117
Clear cell renal cell carcinoma (ccRCC) is characterized by inactivation of the von Hippel-Lindau tumour suppressor gene (VHL). Because no other gene is mutated as frequently in ccRCC and VHL mutations are truncal, VHL inactivation is regarded as the
Publikováno v:
Nature Cell Biology. 18:319-327
The PI(3)K-Akt-mTORC1 pathway is a highly dynamic network that is balanced and stabilized by a number of feedback inhibition loops. Specifically, activation of mTORC1 has been shown to lead to the inhibition of its upstream growth factor signalling.
Autor:
Charles G. Caldwell, Jamie Longgood, Cameron Shokri, Daniel Stroud, Hanzhi Wang, Liela Bayeh, Thomas H. Scheuermann, Christopher E. Sleet, Uttam K. Tambar, Richard K. Bruick, John B. MacMillan, Kevin H. Gardner
Publikováno v:
Journal of Medicinal Chemistry. 58:5930-5941
Hypoxia inducible factor (HIF) transcription factors reside at the center of signaling pathways used by mammalian cells to sense and respond to low oxygen levels. While essential to maintain oxygen homeostasis, misregulation of HIF protein activity c