Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Richard K. Bellingham"'
Autor:
Richard C. D. Brown, Vachiraporn Ajavakom, Potchanee Pandokrak, Sofia S. Salim, Gamal A. I. Moustafa, Richard K. Bellingham, Joseph T. Hill-Cousins, Anawat Ajavakom
Publikováno v:
Synlett. 33:1453-1457
A Grubbs II catalyst mediated ring-closing metathesis (RCM) of monobrominated dienes is reported to proceed in moderate to good yields (40–80%) where the linking chain contains five atoms, leading to carbocyclic and heterocyclic seven-membered brom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6cbcd3d758d1a4ccc30fb46d7df2d6d
https://doi.org/10.1055/a-1845-4195
https://doi.org/10.1055/a-1845-4195
Autor:
Iain R. Miller, Neville J. McLean, Gamal A. I. Moustafa, Vachiraporn Ajavakom, Stephen C. Kemp, Richard K. Bellingham, Nicholas P. Camp, Richard C. D. Brown
Publikováno v:
The Journal of organic chemistry. 87(2)
An asymmetric synthetic route to (-)-galanthamine (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da956b2bcc4aebda32dcb040ed1e711e
https://pubmed.ncbi.nlm.nih.gov/35007075
https://pubmed.ncbi.nlm.nih.gov/35007075
Autor:
Erica Vit, Jerome F. Hayes, Francois-Rene Alexandre, Cyril B. Dousson, Christophe Claude Parsy, David D. Pascoe, Catherine Caillet, Marie-Pierre Lioure, Neil Hodnett, Elodie Rosinovsky, John Edward Richardson, Guillaume Bret, Stéphanie Bot, Agnès Amador, Gary T. Borrett, Bernadette Choudary, Arlène Roland, Daniel Da Costa, Alan Ironmonger, John D. Hayler, Augustine Ochen, Séverine Bonaric, David Colclough, Richard K. Bellingham
Publikováno v:
Organic Process Research & Development. 22:200-206
A new and improved synthetic route to an intermediate in the synthesis of the phosphinate ester GSK2248761A is described. In the key step, we describe the first process-scale example of a palladium-catalyzed phosphorus–carbon coupling to give the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e17aba0e5462710cfa14470fea5b10eb
https://doi.org/10.1021/acs.oprd.7b00356
https://doi.org/10.1021/acs.oprd.7b00356
Autor:
Sofia S. Salim, Richard C. D. Brown, Youssef M. Bakar, Joseph T. Hill-Cousins, Mark E. Light, Richard K. Bellingham
Publikováno v:
Tetrahedron. 70:3700-3706
Ring-closing metathesis (RCM) and sequential Yb(OTf)3 promoted Diels–Alder reactions of sulfamide-linked enynes proceeded selectively in one-pot to afford a series of bicyclic and tricyclic sulfamides. Excellent levels of diastereoselectivity are o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90437c4d6796ccf646a7ec9adf890b44
https://doi.org/10.1016/j.tet.2014.04.014
https://doi.org/10.1016/j.tet.2014.04.014
Autor:
John F. Keily, Richard C. D. Brown, Richard K. Bellingham, Mark E. Light, Amanda C. Cutter, Iain R. Miller
Publikováno v:
Organic Letters. 13:3988-3991
Short routes to enantiomerically pure indolizidine and quinolizidine alkaloids have been developed using imino-aldol reactions of enolates derived from phenyl 5-chlorovalerate. High levels of syn selectivity (dr ∼13-16:1) were obtained using lithiu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8377266e54217af9b58f94f177a9c62
https://doi.org/10.1021/ol2015048
https://doi.org/10.1021/ol2015048
Autor:
Andrew H. Gordon, Michael Urquhart, Matthew J. Peterson, Steve O. Moore, Richard K. Bellingham, A. Mark Buswell, Amin Shamji, Mike Sasse, Bernie M. Choudary
Publikováno v:
Organic Process Research & Development. 14:1254-1263
The discovery and development of an efficient manufacturing route to the CENP-E inhibitor 3-chloro-N-{(1S)-2-[(N,N-dimethylglycyl)amino]-1-[(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)methyl]ethyl}−4-[(1-methylethyl)oxy]benzamide (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d6fa1534e3bec262987cdb817e36b0c
https://doi.org/10.1021/op100186c
https://doi.org/10.1021/op100186c
Autor:
Laurence C. Powling, Nigel Hussain, Richard K. Bellingham, John S. Carey, David O. Morgan, Paul Oxley
Publikováno v:
Organic Process Research & Development. 8:279-282
A modified Knorr pyrrole reaction is described which may have practical benefits for the large-scale synthesis of SB-342219. The use of zinc to reduce a phenylhydrazone is replaced by the hydrogenation of the corresponding oxime to provide a common a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fa4c55302d9774fc3b692603f6fc073
https://doi.org/10.1021/op034198u
https://doi.org/10.1021/op034198u
Publikováno v:
Organic Letters. 5:3403-3406
[reaction: see text] Ring-closing metathesis (RCM) of vinyl fluoride-containing dienes in the presence of ruthenium alkylidene carbene complex 11 proceeded efficiently to give six- and seven-membered cyclic vinyl fluorides. The RCM reaction was used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b719ffe65d954d2a727e312e949ebcc6
https://doi.org/10.1021/ol035065w
https://doi.org/10.1021/ol035065w
Autor:
Richard C. D. Brown, Mark E. Light, Youssef M. Bakar, Joseph T. Hill-Cousins, Richard K. Bellingham, Sofia S. Salim
Publikováno v:
ChemInform. 45
A one-pot procedure for the formation of polycyclic sulfamides via an enyne ring-closing metathesis—Diels—Alder sequence is developed, giving rise to the endo-adducts as the sole observed diastereoisomers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::872b677939f99d92a40705167a215dd1
https://doi.org/10.1002/chin.201439206
https://doi.org/10.1002/chin.201439206
Autor:
Laurence C. Powling, David S. Ennis, David Lathbury, Mark A. Armitage, Paul D. Blackler, Nigel Hussain, Graham H. Oakes, Noah O'Connor, David O. Morgan, Richard K. Bellingham, and Stephen C. Passey, Karl W. Ace
Publikováno v:
Organic Process Research & Development. 5:479-490
A literature route to 1-(2-{4-[(E)-1-(4-iodophenyl)-2-phenyl-but-1-enyl]phenoxy}ethyl)pyrrolidine (idoxifene) has been modified to tackle various scale-up issues and provide initial supplies. A new highly efficient, robust, and stereoselective manufa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f260d40b01d7ee2e398cabc11937c066
https://doi.org/10.1021/op0100394
https://doi.org/10.1021/op0100394