Zobrazeno 1 - 10
of 295
pro vyhledávání: '"Richard K Haynes"'
Autor:
Judith H Waknine-Grinberg, Simcha Even-Chen, Jasmine Avichzer, Keren Turjeman, Annael Bentura-Marciano, Richard K Haynes, Lola Weiss, Nahum Allon, Haim Ovadia, Jacob Golenser, Yechezkel Barenholz
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72722 (2013)
Cerebral malaria is the most severe complication of Plasmodium falciparum infection, and a leading cause of death in children under the age of five in malaria-endemic areas. We report high therapeutic efficacy of a novel formulation of liposome-encap
Externí odkaz:
https://doaj.org/article/e38470b5a7494f86b8547a0492e26c36
Autor:
Rob Hooft van Huijsduijnen, R Kiplin Guy, Kelly Chibale, Richard K Haynes, Ingmar Peitz, Gerhard Kelter, Margaret A Phillips, Jonathan L Vennerstrom, Yongyuth Yuthavong, Timothy N C Wells
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82962 (2013)
We have tested five distinct classes of established and experimental antimalarial drugs for their anticancer potential, using a panel of 91 human cancer lines. Three classes of drugs: artemisinins, synthetic peroxides and DHFR (dihydrofolate reductas
Externí odkaz:
https://doaj.org/article/3601c2ce5a7440359cead33171a26b33
Autor:
Daniel J. Watson, Lizahn Laing, Jacobus P. Petzer, Ho Ning Wong, Christopher J. Parkinson, Lubbe Wiesner, Richard K. Haynes
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Efforts to develop new artemisinin triple combination therapies effective against artemisinin-tolerant strains of Plasmodium falciparum based on rational combinations comprising artemisone or other amino-artemisinins, a redox active drug and a third
Externí odkaz:
https://doaj.org/article/f0b32b20533b40e5ab69e8781098f068
Autor:
Joachim Müller, Carling Schlange, Manfred Heller, Anne-Christine Uldry, Sophie Braga-Lagache, Richard K. Haynes, Andrew Hemphill
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 21, Iss , Pp 1-12 (2023)
The sesquiterpene lactone artemisinin and its amino-artemisinin derivatives artemiside (GC008) and artemisone (GC003) are potent antimalarials. The mode of action of artemisinins against Plasmodium sp is popularly ascribed to 'activation' of the pero
Externí odkaz:
https://doaj.org/article/ab6fe9874f28493880edaf6ef7fc235c
Publikováno v:
Methods and Protocols, Vol 6, Iss 6, p 104 (2023)
We describe the development and validation of a new high performance liquid chromatography (HPLC) method for analysis of a combination of the first-line anti-tubercular drugs isoniazid, pyrazinamide, and rifampicin together with clofazimine. This is
Externí odkaz:
https://doaj.org/article/4c1cf7658abd48afa6851e9d1ef5c3c1
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1348 (2023)
Self-emulsifying drug delivery systems (SEDDSs) are lipid-based systems that are superior to other lipid-based oral drug delivery systems in terms of providing drug protection against the gastrointestinal (GI) environment, inhibition of drug efflux a
Externí odkaz:
https://doaj.org/article/84b8a9f290fe49088e58e32e8c4e5829
Autor:
Jerome P. L. Ng, Yu Han, Li Jun Yang, Lyn-Marie Birkholtz, Dina Coertzen, Ho Ning Wong, Richard K. Haynes, Paolo Coghi, Vincent Kam Wai Wong
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Artemisinin, isolated from the traditional Chinese medicinal plant qīng hāo 青蒿 (Artemisia annua) and its derivatives are used for treatment of malaria. With treatment failures now being recorded for the derivatives and companion drugs used in a
Externí odkaz:
https://doaj.org/article/b5bdae38dcd7468283dd4e8dfca5fc88
Autor:
Daniel J. Watson, Lizahn Laing, Richard M. Beteck, Liezl Gibhard, Richard K. Haynes, Lubbe Wiesner
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The emergence of Plasmodium falciparum (Pf) parasite strains tolerant of the artemisinin component and resistant to the other drug component in artemisinin combination therapies (ACTs) used for treatment now markedly complicates malaria control. Thus
Externí odkaz:
https://doaj.org/article/0fa9857392ad4a1886dbda6556e86f19
Autor:
Lorencia Taljaard, Alexandra Probst, Robert Tornow, Jennifer Keiser, Richard K. Haynes, Frank van der Kooy
Publikováno v:
Phytomedicine Plus, Vol 2, Iss 3, Pp 100279- (2022)
Background: Schistosomiasis, a neglected tropical disease, imposes substantial health and economic burdens on impoverished groups living in predominantly rural areas. Praziquantel (PZQ) is the only drug available for treatment, and it is not complete
Externí odkaz:
https://doaj.org/article/505302c9eb5b43359d033ce34cbf9493
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1293 (2023)
Self-emulsification is considered a formulation technique that has proven capacity to improve oral drug delivery of poorly soluble drugs by advancing both solubility and bioavailability. The capacity of these formulations to produce emulsions after m
Externí odkaz:
https://doaj.org/article/85f9e3e7ed00477e8b59c7ecdd8d2b00