Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Richard K, Hite"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Inositol 1,4,5-trisphosphate receptors (IP3Rs) are endoplasmic reticulum Ca2+ channels whose biphasic dependence on cytosolic Ca2+ gives rise to Ca2+ oscillations that regulate fertilization, cell division and cell death. Despite the critica
Externí odkaz:
https://doaj.org/article/8d3dbc1232e647bebd996269938e7911
Autor:
Yining Jiang, Batiste Thienpont, Vinay Sapuru, Richard K. Hite, Jeremy S. Dittman, James N. Sturgis, Simon Scheuring
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
High-Speed Atomic Force Microscopy movies of membrane proteins — diffusing and interacting in bilayers of controlled thickness — allow the determination of membrane-mediated membrane protein interaction energetics.
Externí odkaz:
https://doaj.org/article/d822ed8623bd4dad8e0d6482980b0861
Autor:
Minfei Su, Navid Paknejad, Lan Zhu, Jinan Wang, Hung Nguyen Do, Yinglong Miao, Wei Liu, Richard K. Hite, Xin-Yun Huang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Su et al. report cryo-EM structures of β1-adrenergic receptor, Gs and ligands of different efficacies. These complexes have similar overall architecture, but with local conformational differences and different stabilities.
Externí odkaz:
https://doaj.org/article/c1df6479c5ba4cfb9c48c1795f9bfd9e
Autor:
Shian Liu, Navid Paknejad, Lan Zhu, Yasuyuki Kihara, Manisha Ray, Jerold Chun, Wei Liu, Richard K. Hite, Xin-Yun Huang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Liu et al. report structures of human sphingosine 1-phosphate (S1P) receptor 1 (S1P1) in complex with Gi and S1P or the multiple sclerosis (MS) drug Siponimod, as well as human lysophosphatidic acid (LPA) receptor 1 (LPA1) in complex with Gi and LPA,
Externí odkaz:
https://doaj.org/article/58134eb70a4a45f6ab8809cc247dec49
Autor:
Marina Schrecker, Juan C Castaneda, Sujan Devbhandari, Charanya Kumar, Dirk Remus, Richard K Hite
Publikováno v:
eLife, Vol 11 (2022)
The DNA sliding clamp proliferating cell nuclear antigen (PCNA) is an essential co-factor for many eukaryotic DNA metabolic enzymes. PCNA is loaded around DNA by the ATP-dependent clamp loader replication factor C (RFC), which acts at single-stranded
Externí odkaz:
https://doaj.org/article/031e4a3eb4824a23a979f88235078d13
Autor:
SeCheol Oh, Fabrizio Marinelli, Wenchang Zhou, Jooyeon Lee, Ho Jeong Choi, Min Kim, José D Faraldo-Gómez, Richard K Hite
Publikováno v:
eLife, Vol 11 (2022)
Structures of the human lysosomal K+ channel transmembrane protein 175 (TMEM175) in open and closed states revealed a novel architecture lacking the canonical K+ selectivity filter motif present in previously known K+ channel structures. A hydrophobi
Externí odkaz:
https://doaj.org/article/7df16728d88c44cd875b5b8a4d68dbdc
Publikováno v:
eLife, Vol 9 (2020)
The chloride-proton exchanger CLC-7 plays critical roles in lysosomal homeostasis and bone regeneration and its mutation can lead to osteopetrosis, lysosomal storage disease and neurological disorders. In lysosomes and the ruffled border of osteoclas
Externí odkaz:
https://doaj.org/article/0d3b68ed2f11477cbed44d09d2053b47
Publikováno v:
eLife, Vol 9 (2020)
Transmembrane protein 175 (TMEM175) is a K+-selective ion channel expressed in lysosomal membranes, where it establishes a membrane potential essential for lysosomal function and its dysregulation is associated with the development of Parkinson’s D
Externí odkaz:
https://doaj.org/article/881d21d9296142f7ba943dcb658d7580
Publikováno v:
eLife, Vol 8 (2019)
Hypoosmotic conditions activate volume-regulated anion channels in vertebrate cells. These channels are formed by leucine-rich repeat-containing protein 8 (LRRC8) family members and contain LRRC8A in homo- or hetero-hexameric assemblies. Here, we pre
Externí odkaz:
https://doaj.org/article/2fdb45c7a2014b01af29964dd29b4eb1
Autor:
Timothy C. Kenny, Artem Khan, Yeeun Son, Lishu Yue, Søren Heissel, Anurag Sharma, H. Amalia Pasolli, Yuyang Liu, Eric R. Gamazon, Hanan Alwaseem, Richard K. Hite, Kıvanç Birsoy
Publikováno v:
Cell Metabolism.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd2684ce13d9910b44287dcae7409fdd
https://doi.org/10.1016/j.cmet.2023.04.003
https://doi.org/10.1016/j.cmet.2023.04.003