Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Richard John Prankerd"'
Autor:
Richard John Prankerd, Robert T. Forbes, Tomas Sou, Lisa M. Kaminskas, Michelle P. McIntosh, David Av Morton, Jason Gray
Publikováno v:
Powder Technology. 287:248-255
For a dry powder formulation platform to be suitable for pulmonary delivery of potent biopharmaceuticals, e.g., proteins and peptides, it has to be not only efficiently and reproducibly aerosolisable, but also capable of creating a matrix suitable fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ccf71de22f7bf77404db69a2e19fe87
https://doi.org/10.1016/j.powtec.2015.10.008
https://doi.org/10.1016/j.powtec.2015.10.008
Publikováno v:
Pharmaceutical Biology. 53:1719-1726
Natural products play a vital role in the discovery of leads for novel pharmacologically active drugs. Geraniin (GE) was identified as the major compound in the rind of Nephelium lappaceum L. (Sapindaceae), while ellagic and gallic acids have been sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac4d25969a2a0e62302649ae4d8a684
https://doi.org/10.3109/13880209.2014.1003356
https://doi.org/10.3109/13880209.2014.1003356
Autor:
Richard John Prankerd, Philip Wright, Tri-Hung Nguyen, Seloi Mogatle, Rajpreet Singh Minhas, Peter Lambert, Kim Deadman, Claire Louise McEvoy, Michelle P. McIntosh
Publikováno v:
BMJ Open
IntroductionOxytocin, administered via injection, is recommended by WHO for the prevention and treatment of postpartum haemorrhage. However, the susceptibility of oxytocin injection to thermal degradation has led WHO and UNICEF to recommend cold-chai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82392fd5466254d6f5591d2f2b64dc34
https://doi.org/10.1136/bmjopen-2019-029083
https://doi.org/10.1136/bmjopen-2019-029083
Autor:
Richard John Prankerd, Tomas Sou, Michelle P. McIntosh, David Alexander Vodden Morton, Lisa M. Kaminskas
Publikováno v:
Drying Technology. 31:1451-1458
Non-reducing sugars such as mannitol are widely studied as excipients for spray-dried pharmaceutical formulations. In contrast, the present study investigated the use of a range of polymers for the production of an amorphous glassy carrier platform f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::844821e7c94ce6f4dbc0a1dbac4a90e3
https://doi.org/10.1080/07373937.2013.788019
https://doi.org/10.1080/07373937.2013.788019
Autor:
Elizabeth Yuriev, David K. Chalmers, David T. Manallack, Mark Robert Kelly, Matthew L. Dennis, Richard John Prankerd
Publikováno v:
Molecular Informatics. 32:505-515
Human small molecule metabolites (the human metabolome) are a set of compounds that interact with at least one macromolecule in the biosphere. This study investigates the acid/base profile of the human metabolome, natural products and drugs, together
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::332ea6efe6e1aa2571022c8b3e7f54d5
https://doi.org/10.1002/minf.201200167
https://doi.org/10.1002/minf.201200167
Autor:
Tudor I. Oprea, Gemma Nassta, David K. Chalmers, Richard John Prankerd, David T. Manallack, Oleg Ursu
Publikováno v:
ChemMedChem. 8:242-255
Chemogenomics methods seek to characterize the interaction between drugs and biological systems and are an important guide for the selection of screening compounds. The acid/base character of drugs has a profound influence on their affinity for the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8780526265129f7a93616c1881f639
https://doi.org/10.1002/cmdc.201200507
https://doi.org/10.1002/cmdc.201200507
Autor:
Tudor I. Oprea, David K. Chalmers, David T. Manallack, Elizabeth Yuriev, Richard John Prankerd
Publikováno v:
Chem. Soc. Rev.. 42:485-496
While drug discovery scientists take heed of various guidelines concerning drug-like character, the influence of acid/base properties often remains under-scrutinised. Ionisation constants (pK(a) values) are fundamental to the variability of the bioph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d6a4705ae4d3fa6cade3aa87fa138a
https://doi.org/10.1039/c2cs35348b
https://doi.org/10.1039/c2cs35348b
Publikováno v:
Journal of Pharmaceutical Sciences. 101:3347-3359
Interaction of colistin and colistin methanesulfonate (CMS) with liposomes has been studied with the view to understanding the limitations to the use of liposomes as a more effective delivery system for pulmonary inhalation of this important class of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d0af6bb8b3550f2056b1a3d999a1193
https://doi.org/10.1002/jps.23203
https://doi.org/10.1002/jps.23203
Autor:
Richard John Prankerd, Kasiram Katneni, David M. Shackleford, Nathania Leong, Michelle P. McIntosh, Julia Morizzi
Publikováno v:
Journal of Pharmaceutical Sciences. 99:2999-3008
Chlorpromazine is an antipsychotic agent with poor aqueous solubility. Complexation with SBE(7)-beta-CD can aid intravenous delivery through increasing the apparent solubility of chlorpromazine. However, chlorpromazine has also been known to self-ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b51648c0e525f2ecd644b7cbfa9c86b
https://doi.org/10.1002/jps.22064
https://doi.org/10.1002/jps.22064
Autor:
Richard John Prankerd, Roger L. Nation, Jian Li, Tony Velkov, Stephanie Jean Wallace, Benjamin James Boyd
Publikováno v:
The Journal of Physical Chemistry B. 114:4836-4840
Colistin is an amphiphilic antibiotic that has re-emerged into clinical use due to the increasing prevalence of difficult-to-treat Gram-negative infections. The existence of self-assembling colloids in solutions of colistin and its derivative prodrug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be2429ab9d5fb6db4d28a8ec3b6815eb
https://doi.org/10.1021/jp100458x
https://doi.org/10.1021/jp100458x