Zobrazeno 1 - 3
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pro vyhledávání: '"Richard James Edsall"'
Autor:
Richard Eric Mewshaw, James C. Keith, Eric S. Manas, Cuijian Yang, Ruth A. Henderson, Heather A. Harris, Richard James Edsall, Zhang B. Xu
Publikováno v:
Journal of Medicinal Chemistry. 48:3953-3979
The 2-phenylnaphthalene scaffold was explored as a simplified version of genistein in order to identify ER selective ligands. With the aid of docking studies, positions 1, 4, and 8 of the 2-phenylnaphthalene template were predicted to be the most pot
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:3457-3474
The synthesis and structure–activity relationships of a series of simple biphenyls is described. Optimization of the 4-hydroxy-biphenyl template led to compounds with ERβ selectivity on the order of 20–70-fold.
Autor:
Richard Eric Mewshaw, Xiaochun Zhang, Cuijian Yang, Heather A. Harris, Eric S. Manas, Richard James Edsall
Publikováno v:
Bioorganicmedicinal chemistry. 12(10)
A series of biphenyl carbaldehyde oximes (6) was prepared and shown to have significant selectivity for the estrogen receptor-beta (ERbeta). The exploitation of the oxime moiety as a hydrogen bond donating group, which mimicked the C-ring of genistei