Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Richard J. Spandl"'
Autor:
Warren R. J. D. Galloway, Gemma L. Thomas, David R. Spring, Richard J. Spandl, David S. Surry, Xianbin Su
Publikováno v:
Synthesis. 2009:3880-3896
In this feature article we discuss the construction of biaryl-containingmedium-sized rings by organocuprate oxidation and the applicationof this chemistry in the synthesis of members of the ellagitanninfamily of natural products. A concise and effici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6afc45498fe1d1166973266cd8cb358e
https://doi.org/10.1055/s-0029-1218154
https://doi.org/10.1055/s-0029-1218154
Autor:
Rebecca L. Nicholson, Gemma L. Thomas, James T. Hodgkinson, David M. Marsden, Martin Welch, George P. C. Salmond, David R. Spring, Xianbin Su, Richard J. Spandl
Publikováno v:
Synlett. 2008:2122-2126
The synthesis of bacterial quorum-sensing regulator N-(3-oxohexanoyl)-L-homoserine lactone (OHHL) and biotin-tagged OHHL is reported. The latter will be applied to developing a general method to address the 'target identification problem' in chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcf09315d4ed6f031c2d6e2351680fdc
https://doi.org/10.1055/s-2008-1077978
https://doi.org/10.1055/s-2008-1077978
Autor:
Gemma L. Thomas, Richard J. Spandl, Freija G. Glansdorp, Martin Welch, Andreas Bender, Joshua Cockfield, Jodi A. Lindsay, Clare Bryant, Derek F. J. Brown, Olivier Loiseleur, Hélène Rudyk, Mark Ladlow, David R. Spring
Publikováno v:
Angewandte Chemie. 120:2850-2854
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf72d30bf63d01d640e348a4c8593b0d
https://doi.org/10.1002/ange.200705415
https://doi.org/10.1002/ange.200705415
Autor:
Freija G. Glansdorp, Derek F. J. Brown, Mark Ladlow, Gemma L. Thomas, Joshua D. Cockfield, Jodi A. Lindsay, Helene Rudyk, Martin Welch, David R. Spring, Olivier Loiseleur, Andreas Bender, Richard J. Spandl, Clare E. Bryant
Publikováno v:
Angewandte Chemie International Edition. 47:2808-2812
Antibacterial drugs have played an essential role in the global increase in quality of life and life expectancy. However, these gains are at serious risk owing to bacterial drug resistance by so-called “superbugs”, such as methicillin-resistant S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df18e421f9b276e7297a4e592d1baece
https://doi.org/10.1002/anie.200705415
https://doi.org/10.1002/anie.200705415
Autor:
Richard J. Spandl, David R. Spring, Monica Diaz‐Gavilan, Gemma L. Thomas, Kieron M. G. O'Connell
Publikováno v:
Solid-Phase Organic Synthesis: Concepts, Strategies, and Applications
Diversity-oriented synthesis (DOS), which describes the synthesis of structurally diverse collections of small molecules, was developed, in part, to address combinatorial chemistry's shortfalls. In this paper, we hope to give an indication of what ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd43098814d4e8f90a18dca32546e342
https://doi.org/10.1002/tcr.20144
https://doi.org/10.1002/tcr.20144
Autor:
Warren R. J. D. Galloway, Richard J. Spandl, Andreas Bender, Gemma L. Thomas, Monica Diaz-Gavilan, Kieron M. G. O’Connell, David R. Spring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bdfc7f8b3a596a80a1e2c9ec7c980de
https://doi.org/10.1017/cbo9781139021500.007
https://doi.org/10.1017/cbo9781139021500.007
Autor:
Richard J. Spandl, Gemma L. Thomas, Monica Diaz-Gavilan, Kieron M. G. O'Connell, David R. Spring
Publikováno v:
ChemInform. 41
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef90319beef28159207fdb32ab33bd7a
https://doi.org/10.1002/chin.201043253
https://doi.org/10.1002/chin.201043253
Autor:
Monica Diaz‐Gavilan, Richard J. Spandl, David R. Spring, Kieron M. G. O'Connell, Gemma L. Thomas
Publikováno v:
Linker Strategies in Solid-Phase Organic Synthesis
1.1 Introduction 1 1.2 Exploring Chemical Space 2 1.3 Sources of Skeletally Diverse Small Molecules 3 1.4 Enriching Chemical Space Using DOS 4 1.5 The Subjective Nature of ‘Diversity’ 4 1.6 Differing Strategies Towards Similar Goals 5 1.6.1 DOS b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f0b40f6ffa9f203bf27f6d6a49aa76c
https://doi.org/10.1002/9780470749043.ch8
https://doi.org/10.1002/9780470749043.ch8
Autor:
Richard J. Spandl, Kieron M. G. O'Connell, Gemma L. Thomas, Monica Diaz‐Gavilan, David R. Spring
Publikováno v:
ChemInform. 40
Diversity-oriented synthesis (DOS), which describes the synthesis of structurally diverse collections of small molecules, was developed, in part, to address combinatorial chemistry's shortfalls. In this paper, we hope to give an indication of what ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95e6093d3510ff28a6adf1eb8ec3037c
https://doi.org/10.1002/chin.200927246
https://doi.org/10.1002/chin.200927246
Autor:
Martin Welch, David R. Spring, Olivier Loiseleur, Jane E. Swatton, Richard J. Spandl, Freija G. Glansdorp
Publikováno v:
Organicbiomolecular chemistry. 6(22)
The antibacterial drug azithromycin has clinically beneficial effects at sub-inhibitory concentrations for the treatment of conditions characterized by chronic Pseudomonas aeruginosa infection, such as cystic fibrosis. These effects are, in part, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9141ed31c56e48be95dd78152831e380
https://pubmed.ncbi.nlm.nih.gov/18972042
https://pubmed.ncbi.nlm.nih.gov/18972042