Výsledky vyhledávání - "Richard J. Pylilo"

Simultaneous determination of p-hydroxylated and dihydrodiol metabolites of phenytoin in urine by high-performance liquid chromatography

Autor: George K. Szabo, Hamid Davoudi, Richard J. Pylilo, Thomas R. Browne

Publikováno v: Journal of Chromatography A. 535:279-285

Accurate urinary measurements of the two major metabolites of phenytoin, 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) and 5-(3,4-dihydroxy-cyclohexa-1,5-dienyl)-5-phenylhydantoin (dihydrodiol, DHD), are necessary for pharmacokinetic and drug-intera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c89320a22a7315217c738854735bc5
https://doi.org/10.1016/s0021-9673(01)88953-6

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Simultaneous separation and determination (in serum) of phenytoin and carbamazepine and their deuterated analogues by high-performance liquid chromatography--ultraviolet detection for tracer studies

Autor: George K. Szabo, Thomas R. Browne, Richard J. Pylilo, Robert J. Perchalski

Publikováno v: Journal of chromatography. 535(1-2)

The use of stable isotope-labeled tracer compounds is the safest and most effective method to perform many steady state pharmacokinetic and drug interaction studies. We describe a method by which the heavily deuterated 2H10 analogues of carbamazepine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b010f024a07d8cf856e8561d1e95d3c
https://pubmed.ncbi.nlm.nih.gov/2089056

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