Zobrazeno 1 - 10
of 556
pro vyhledávání: '"Richard J. Miller"'
Autor:
Alia M. Obeidat, Shingo Ishihara, Jun Li, Natalie S. Adamczyk, Lindsey Lammlin, Lucas Junginger, Tristan Maerz, Richard J. Miller, Rachel E. Miller, Anne-Marie Malfait
Publikováno v:
Frontiers in Neuroanatomy, Vol 18 (2024)
ObjectiveKnee joints are densely innervated by nociceptors. In human knees and rodent models, sprouting of nociceptors has been reported in late-stage osteoarthritis (OA). Here, we sought to describe progressive nociceptor remodeling in early and lat
Externí odkaz:
https://doaj.org/article/c82aa8c802ea4995988701bde3079ef6
Autor:
Alia M. Obeidat, Matthew J. Wood, Natalie S. Adamczyk, Shingo Ishihara, Jun Li, Lai Wang, Dongjun Ren, David A. Bennett, Richard J. Miller, Anne-Marie Malfait, Rachel E. Miller
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Non-opioid targets are needed for addressing osteoarthritis pain, which is mechanical in nature and associated with daily activities such as walking and climbing stairs. Piezo2 has been implicated in the development of mechanical pain, but t
Externí odkaz:
https://doaj.org/article/222c434eeda94f0a8702d3c3debb578f
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Peripheral neuropathic pain (PNP), neuropathic pain that arises from a damage or disease affecting the peripheral nervous system, is associated with an extremely large disease burden, and there is an increasing and urgent need for new therapies for t
Externí odkaz:
https://doaj.org/article/e8046f63fe4d404490b1fd8f7ed27b8c
Autor:
Robin Vroman, Rahel S. Hunter, Matthew J. Wood, Olivia C. Davis, Zoë Malfait, Dale S. George, Dongjun Ren, Diana Tavares-Ferreira, Theodore J. Price, Richard J. Miller, Anne-Marie Malfait, Fransiska Malfait, Rachel E. Miller, Delfien Syx
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
The extracellular matrix (ECM) is a dynamic structure of molecules that can be divided into six different categories and are collectively called the matrisome. The ECM plays pivotal roles in physiological processes in many tissues, including the nerv
Externí odkaz:
https://doaj.org/article/87f54fe5bb164f508a368543eff00691
Autor:
Shingo Ishihara, Alia M. Obeidat, David L. Wokosin, Dongjun Ren, Richard J. Miller, Anne-Marie Malfait, Rachel E. Miller
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-12 (2021)
Abstract Background C–C chemokine receptor 2 (CCR2) signaling plays a key role in pain associated with experimental murine osteoarthritis (OA) after destabilization of the medial meniscus (DMM). Here, we aimed to assess if CCR2 expressed by intra-a
Externí odkaz:
https://doaj.org/article/f167f2cb2b02483c85aff3a5e8fb88a5
Autor:
Mohammad Mehdi Maneshi, Anna B. Toth, Toshiyuki Ishii, Kotaro Hori, Shogo Tsujikawa, Andrew K. Shum, Nisha Shrestha, Megumi Yamashita, Richard J. Miller, Jelena Radulovic, Geoffrey T. Swanson, Murali Prakriya
Publikováno v:
Cell Reports, Vol 34, Iss 13, Pp 108911- (2021)
Externí odkaz:
https://doaj.org/article/1e4e197b0b404284ad49a56410d982ec
Publikováno v:
PAIN Reports, Vol 6, Iss 1, p e892 (2021)
Abstract. Bidirectional interactions between the immune system and the nervous system are increasingly appreciated as playing a pathogenic role in chronic pain. Unraveling the mechanisms by which inflammatory pain is mediated through communication be
Externí odkaz:
https://doaj.org/article/e7f94a7ea7b44905b95fb9262d12d3bd
Autor:
Mohammad Mehdi Maneshi, Anna B. Toth, Toshiyuki Ishii, Kotaro Hori, Shogo Tsujikawa, Andrew K. Shum, Nisha Shrestha, Megumi Yamashita, Richard J. Miller, Jelena Radulovic, Geoffrey T. Swanson, Murali Prakriya
Publikováno v:
Cell Reports, Vol 33, Iss 9, Pp 108464- (2020)
Summary: Store-operated Orai1 calcium channels function as highly Ca2+-selective ion channels and are broadly expressed in many tissues including the central nervous system, but their contributions to cognitive processing are largely unknown. Here, w
Externí odkaz:
https://doaj.org/article/04076d837bbd42dc9fc8fee6e1855624
Autor:
Javier H. Jara, Barış Genç, Macdonell J. Stanford, Peter Pytel, Raymond P. Roos, Sandra Weintraub, M. Marsel Mesulam, Eileen H. Bigio, Richard J. Miller, P. Hande Özdinler
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-20 (2017)
Abstract Background Recent evidence indicates the importance of innate immunity and neuroinflammation with microgliosis in amyotrophic lateral sclerosis (ALS) pathology. The MCP1 (monocyte chemoattractant protein-1) and CCR2 (CC chemokine receptor 2)
Externí odkaz:
https://doaj.org/article/97c3d0e9ad8a4982a0dcf8b1afc51f08
Autor:
Yanxia Guo, Kenzie D. MacIsaac, Yi Chen, Richard J. Miller, Renu Jain, Barbara Joyce-Shaikh, Heidi Ferguson, I-Ming Wang, Razvan Cristescu, John Mudgett, Laura Engstrom, Kyle J. Piers, Gretchen A. Baltus, Kenneth Barr, Hongjun Zhang, Huseyin Mehmet, Laxminarayan G. Hegde, Xiao Hu, Laura L. Carter, Thomas D. Aicher, Gary Glick, Dennis Zaller, Abbas Hawwari, Craig C. Correll, Dallas C. Jones, Daniel J. Cua
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3206-3218 (2016)
Recent studies have elucidated the molecular mechanism of RORγT transcriptional regulation of Th17 differentiation and function. RORγT was initially identified as a transcription factor required for thymopoiesis by maintaining survival of CD4+CD8+
Externí odkaz:
https://doaj.org/article/2fa0a8401c4b4b669f283988d06b8908