Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Richard J. McKenney"'
Autor:
Kyoko Okada, Bharat R. Iyer, Lindsay G. Lammers, Pedro A. Gutierrez, Wenzhe Li, Steven M. Markus, Richard J. McKenney
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Processive transport by the microtubule motor cytoplasmic dynein requires the regulated assembly of a dynein-dynactin-adapter complex. Interactions between dynein and dynactin were initially ascribed to the dynein intermediate chain N-termin
Externí odkaz:
https://doaj.org/article/986beca8951b42fa9ebd4f5a2cf41ad4
Autor:
Xiangyu Fan, Richard J. McKenney
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Microtubules are major components of the eukaryotic cytoskeleton. Posttranslational modifications (PTMs) of tubulin regulates interactions with microtubule-associated proteins (MAPs). One unique PTM is the cyclical removal and re-addition of
Externí odkaz:
https://doaj.org/article/3ad89f0173034f789b975b3093079f86
Publikováno v:
eLife, Vol 9 (2020)
Lissencephaly (‘smooth brain’) is a severe brain disease associated with numerous symptoms, including cognitive impairment, and shortened lifespan. The main causative gene of this disease – lissencephaly-1 (LIS1) – has been a focus of intense
Externí odkaz:
https://doaj.org/article/bc58bf1ae8ee4131a4ced3c53e5f56df
Autor:
Tatyana Bodrug, Elizabeth M Wilson-Kubalek, Stanley Nithianantham, Alex F Thompson, April Alfieri, Ignas Gaska, Jennifer Major, Garrett Debs, Sayaka Inagaki, Pedro Gutierrez, Larisa Gheber, Richard J McKenney, Charles Vaughn Sindelar, Ronald Milligan, Jason Stumpff, Steven S Rosenfeld, Scott T Forth, Jawdat Al-Bassam
Publikováno v:
eLife, Vol 9 (2020)
Kinesin-5 motors organize mitotic spindles by sliding apart microtubules. They are homotetramers with dimeric motor and tail domains at both ends of a bipolar minifilament. Here, we describe a regulatory mechanism involving direct binding between tai
Externí odkaz:
https://doaj.org/article/df2534919cf44fd39e58c822475e8f4e
The tumor suppressor BRCA1-BARD1 complex functions in many cellular processes; of critical importance to its tumor suppressor function is its role in genome integrity. Although RING E3 ubiquitin ligase activity is the only known enzymatic activity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6048b20bcd5083b276c9d3f2b1922164
https://doi.org/10.1101/2022.10.02.510574
https://doi.org/10.1101/2022.10.02.510574
Autor:
Xiangyu Fan, Richard J. McKenney
Microtubules are a major component of the eukaryotic cytoskeleton that play crucial roles in diverse cellular process. Posttranslational modifications (PTMs) of tubulin dimers regulate the dynamics and organization of microtubules, as well as the int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28163fd31baa790569a0f11f7e727c29
https://doi.org/10.1101/2022.08.09.503328
https://doi.org/10.1101/2022.08.09.503328
Autor:
Amit Rahi, Manas Chakraborty, Shivangi Agarwal, Kristen Vosberg, Shivani Agarwal, Annie Y. Wang, Richard J. McKenney, Dileep Varma
The Ndc80 kinetochore complex is essential for robust kinetochore-microtubule (k-MT) attachments during mitosis. Ndc80 has been shown to recruit the Ska1 complex to kinetochores, where Ska1 is thought to aid in k-MT coupling by Ndc80. Our previous wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cea2f1cfb12136a56891239f9b4d033
https://doi.org/10.1101/2022.05.05.490787
https://doi.org/10.1101/2022.05.05.490787
Autor:
Iris Har-Vardi, Richard J. McKenney, Saad El Riati, Ohad Wormser, Kyoko Okada, Maurizio Gatti, Lucia Graziadio, Eliahu Levitas, Silvia Bonaccorsi, Anna Bakhrat, Ygal Levy, Mahmoud Huleihel, Uri Abdu, Ali AbuMadighem, Ohad S. Birk
Publikováno v:
Journal of Medical Genetics. 58:254-263
BackgroundMutationin S-phase cyclin A-associated protein rin the endoplasmic reticulum(SCAPER) have been found across ethnicities and have been shown to cause variable penetrance of an array of pathological traits, including intellectual disability,
Autor:
Sana Afreen, Amit Rahi, Adriana G. Landeros, Manas Chakraborty, Richard J. McKenney, Dileep Varma
Publikováno v:
Methods in Molecular Biology ISBN: 9781071619032
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b912db51f71304d19d0c1d69f856483f
https://doi.org/10.1007/978-1-0716-1904-9_9
https://doi.org/10.1007/978-1-0716-1904-9_9