Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Richard J. Kulmacz"'
Publikováno v:
Catalysts, Vol 4, Iss 2, Pp 174-185 (2014)
Conversion of arachidonic acid to prostaglandin G2/H2 catalyzed by prostaglandin H synthase (PGHS) is proposed to involve initial transfer of the C13 pro-(S) hydrogen atom from arachidonate to the Tyr385 radical in PGHS, followed by insertion of two
Externí odkaz:
https://doaj.org/article/deb721e61ebc4b9483abab29059d676a
Autor:
Cornelia M. Ulrich, John D. Potter, Karen W. Makar, Peter S. Rabinovitch, Christopher S. Carlson, Richard J. Kulmacz, Liren Xiao, Li Hsu, Elizabeth M. Poole
Background: Prostaglandins are important inflammatory mediators; prostaglandin E2 (PGE2) is the predominant prostaglandin in colorectal neoplasia and affects colorectal carcinogenesis. Prostaglandins are metabolites of ω-6 and ω-3 polyunsaturated f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0afeb1c222fbe0a7307aa352fa70b486
https://doi.org/10.1158/1055-9965.c.6514947.v1
https://doi.org/10.1158/1055-9965.c.6514947.v1
Autor:
Cornelia M. Ulrich, John D. Potter, Karen W. Makar, Peter S. Rabinovitch, Christopher S. Carlson, Richard J. Kulmacz, Liren Xiao, Li Hsu, Elizabeth M. Poole
Supplementary Tables 1-9, Supplementary Figure 1 from Genetic Variation in Prostaglandin E2 Synthesis and Signaling, Prostaglandin Dehydrogenase, and the Risk of Colorectal Adenoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b9bd1e90dc3b610d4707fb89442de0a
https://doi.org/10.1158/1055-9965.22435476
https://doi.org/10.1158/1055-9965.22435476
Autor:
Alexandra Janda, Stephanie E. Wallace, Claudio F. Russo, Dongchuan Guo, Guillaume Jondeau, Dianna M. Milewicz, Ellen M. Hostetler, Catherine Boileau, Nadine Hanna, Roberto Colombo, Tami Johnston, Bo Carlberg, Kwanghyuk Lee, Christian Antolik, Ellen S. Regalado, Suzanne M. Leal, Limin Gong, Richard J. Kulmacz, Matias Hannuksela, Pauline Arnaud
Publikováno v:
Genetics in Medicine. 21:144-151
Purpose: Heritable thoracic aortic disease can result from null variants in MYLK, which encodes myosin light-chain kinase (MLCK). Data on which MYLKmissense variants are pathogenic and information ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61c490cd42b72834e9fd8f7364652c6
https://doi.org/10.1038/s41436-018-0038-0
https://doi.org/10.1038/s41436-018-0038-0
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 359:134-141
The inhibition of platelet aggregation is key to preventing conditions such as myocardial infarction and ischemic stroke. Aspirin is the most widely used drug to inhibit platelet aggregation. Aspirin absorption can be improved further to increase its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cfde263fe275eca133b072c4ab1e77e
https://doi.org/10.1124/jpet.116.234781
https://doi.org/10.1124/jpet.116.234781
Autor:
Alexandra Janda, Jian Huang, Richard J. Kulmacz, James T. Stull, Xue Yan Duan, Dongchuan Guo, Kristine E. Kamm, Limin Gong, Jiyuan Chen, Dianna M. Milewicz, Shanzhi Wang, Callie S. Kwartler
Thoracic aortic aneurysms leading to acute aortic dissections are a preventable cause of premature deaths if individuals at risk can be identified. Individuals with early-onset aortic dissections without a family history or syndromic features have an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612a8c0ca3edea34b38a9a69b8581259
https://europepmc.org/articles/PMC6035370/
https://europepmc.org/articles/PMC6035370/
Autor:
Deborah A. Nickerson, Ellen S. Regalado, Dongchuan Guo, Richard J. Kulmacz, Dianna M. Milewicz, Ellen M. Hostetler, Di Zhang, Yuxin Fan, GenTAC Registry Investigators, Scott A. LeMaire, Suzanne M. Leal
An acute aortic dissection is a life-threatening cardiovascular condition that is preventable if individuals at risk are identified. Pathogenic variants in 11 genes confer a highly penetrant, dominantly inherited risk for aortic aneurysms and dissect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a273aed4ca557ca9f5127dce5fe2f929
https://europepmc.org/articles/PMC6047350/
https://europepmc.org/articles/PMC6047350/
Publikováno v:
Catalysts, Vol 4, Iss 2, Pp 174-185 (2014)
Conversion of arachidonic acid to prostaglandin G2/H2 catalyzed by prostaglandin H synthase (PGHS) is proposed to involve initial transfer of the C13 pro-(S) hydrogen atom from arachidonate to the Tyr385 radical in PGHS, followed by insertion of two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39400f9c620b454db47e6e287f90cc65
http://www.mdpi.com/2073-4344/4/2/174
http://www.mdpi.com/2073-4344/4/2/174
Autor:
Li Hsu, Mark A. Jenkins, Peter T. Campbell, Karen W. Makar, Cornelia M. Ulrich, Sarah E. Kleinstein, John L. Hopper, John D. Potter, Anna E. Coghill, Elizabeth M. Poole, Polly A. Newcomb, Johanna W. Lampe, John A. Baron, Jane C. Figueiredo, Liren Xiao, Dominique Scherer, Lisel Koepl, Katharina Buck, Yesilda Balavarca, Aung Ko Win, Richard J. Kulmacz
Publikováno v:
Genes, Chromosomes and Cancer. 53:568-578
The use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with reduced risk of colorectal neoplasia. Previous studies have reported that polymorphisms in NSAID-metabolizing enzymes central to NSAID metabolism including UDP-glucuronosylt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d338671abcdd76d16609a3c3146ad3fa
https://doi.org/10.1002/gcc.22167
https://doi.org/10.1002/gcc.22167
Autor:
Polly A. Newcomb, Elizabeth M. Poole, Brenna L. Seufert, John Whitton, Richard J. Kulmacz, John D. Potter, Peter T. Campbell, Liren Xiao, John A. Baron, Martha L. Slattery, Karen W. Makar, Cornelia M. Ulrich
Publikováno v:
Carcinogenesis. 34:79-85
The NFκB-signaling pathway regulates cell proliferation and inflammation. Activation of the pathway is implicated in the etiology of colorectal cancer (CRC). NSAIDs may reduce CRC risk partially through a nuclear factor-kappa B (NFκB)-dependent pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb3b86799de75cabe953bd82b0a1845
https://doi.org/10.1093/carcin/bgs296
https://doi.org/10.1093/carcin/bgs296