Výsledky vyhledávání - "Richard J. Heath"

Akademický článek

Oral Administration of Astrovirus Capsid Protein Is Sufficient To Induce Acute Diarrhea In Vivo

Autor: Victoria A. Meliopoulos, Shauna A. Marvin, Pamela Freiden, Lindsey A. Moser, Prashant Nighot, Rizwana Ali, Anthony Blikslager, Muralidhar Reddivari, Richard J. Heath, Matthew D. Koci, Stacey Schultz-Cherry

Publikováno v: mBio, Vol 7, Iss 6 (2016)

ABSTRACT The disease mechanisms associated with the onset of astrovirus diarrhea are unknown. Unlike other enteric virus infections, astrovirus infection is not associated with an inflammatory response or cellular damage. In vitro studies in differen

Externí odkaz: https://doaj.org/article/eea64f2f4c4548f188b74334aaaa9837

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Supplementary Figure S4 from The Common Germline TP53-R337H Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model

Autor: Gerard P. Zambetti, Raul C. Ribeiro, Stanley Pounds, Wenan Chen, Carlos Rodriguez-Galindo, Alberto S. Pappo, Bonald C. Figueiredo, Enzo Lalli, Guillermina Lozano, Richard J. Heath, Geoffrey Neale, Jinling Wang, Michael R. Clay, Jerold E. Rehg, Emilia M. Pinto, John R. Jeffers

Strong nuclear staining of mutant TP53-R337H protein in normal tissue of carriers who developed ACC.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ad77f823b3f7febdb203507dd8cca0
https://doi.org/10.1158/0008-5472.22430475

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Supplementary Table S1 from The Common Germline TP53-R337H Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model

Mouse Cohorts and Associated Pathology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15824bbc63ea56bc3cbee75db5a98b67
https://doi.org/10.1158/0008-5472.22430451

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Data from The Common Germline TP53-R337H Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model

The TP53-R337H founder mutation exists at a high frequency throughout southern Brazil and represents one of the most common germline TP53 mutations reported to date. It was identified in pediatric adrenocortical tumors in families with a low incidenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57457eee8b893667a15d30dc48dfd22f
https://doi.org/10.1158/0008-5472.c.6513618.v1

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Supplementary Data from The Common Germline TP53-R337H Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model

Supplemental Materials and Methods and Supplementary Figure Legends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b36822fc00ebb91ba52482cf21a2974
https://doi.org/10.1158/0008-5472.22430487.v1

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The Common Germline TP53-R337H Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model

Autor: Bonald C. Figueiredo, Jerold E. Rehg, Richard J. Heath, Alberto S. Pappo, Jinling Wang, Carlos Rodriguez-Galindo, Geoffrey Neale, Guillermina Lozano, Raul C. Ribeiro, Stanley Pounds, Wenan Chen, John R. Jeffers, Gerard P. Zambetti, Enzo Lalli, Emilia M. Pinto, Michael R. Clay

Publikováno v: Cancer Research. 81:2442-2456

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::722d27f9c7de12c20c01a537a3f7cfec
https://doi.org/10.1158/0008-5472.can-20-1750

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Akademický článek

Generation of a lentiviral vector producer cell clone for human Wiskott-Aldrich syndrome gene therapy

Autor: Matthew M Wielgosz, Yoon-Sang Kim, Gael G Carney, Jun Zhan, Muralidhar Reddivari, Terry Coop, Richard J Heath, Scott A Brown, Arthur W Nienhuis

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 2, Iss , Pp - (2015)

We have developed a producer cell line that generates lentiviral vector particles of high titer. The vector encodes the Wiskott-Aldrich syndrome (WAS) protein. An insulator element has been added to the long terminal repeats of the integrated vector

Externí odkaz: https://doaj.org/article/27d92fe69dac4a3383af7190984f7673

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Structural and Biochemical Features of Human Serum Albumin Essential for Eukaryotic Cell Culture

Autor: Richard J. Heath, Vibhor Mishra

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 8411, p 8411 (2021)

Serum albumin physically interacts with fatty acids, small molecules, metal ions, and several other proteins. Binding with a plethora of bioactive substances makes it a critical transport molecule. Albumin also scavenges the reactive oxygen species t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f390cc4973b6c5bfae747ba5edd5389
http://europepmc.org/articles/PMC8395139

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Mechanisms of NT5C2-Mediated Thiopurine Resistance in Acute Lymphoblastic Leukemia

Autor: William L. Carroll, Jing Li, Richard J. Heath, Xujie Zhao, Takaya Moriyama, Shuguang Liu, Youming Shao, Aleš Hnízda, Julia Meyer, Jun J. Yang, Wentao Yang

Publikováno v: Molecular Cancer Therapeutics. 18:1887-1895

Relapse remains a formidable challenge for acute lymphoblastic leukemia (ALL). Recently, recurrent mutations in NT5C2 were identified as a common genomic lesion unique in relapsed ALL and were linked to acquired thiopurine resistance. However, molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2fdc6f522a622a076f34d52e6472cb9c
https://doi.org/10.1158/1535-7163.mct-18-1112

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