Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Richard J. Heads"'
Publikováno v:
Current Research in Physiology, Vol 4, Iss , Pp 103-118 (2021)
In modern society, cardiovascular disease remains the biggest single threat to life, being responsible for approximately one third of worldwide deaths. Male prevalence is significantly higher than that of women until after menopause, when the prevale
Externí odkaz:
https://doaj.org/article/c068fee6a1bc42ddbd9f89a35c360695
Publikováno v:
Mediators of Inflammation, Vol 2021 (2021)
Causes of mortality from COVID-19 include respiratory failure, heart failure, and sepsis/multiorgan failure. TLR4 is an innate immune receptor on the cell surface that recognizes pathogen-associated molecular patterns (PAMPs) including viral proteins
Externí odkaz:
https://doaj.org/article/64c44170406b4a2eb3a941bd0a23e28c
Publikováno v:
Current Research in Physiology
Current Research in Physiology, Vol 4, Iss, Pp 103-118 (2021)
Current Research in Physiology, Vol 4, Iss, Pp 103-118 (2021)
In modern society, cardiovascular disease remains the biggest single threat to life, being responsible for approximately one third of worldwide deaths. Male prevalence is significantly higher than that of women until after menopause, when the prevale
In modern society, cardiovascular disease remains the biggest single threat to life, being responsible for approximately 1/3 of worldwide deaths. Male prevalence is significantly higher than that of women until after menopause, when the prevalence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::389ce51698e8a1fc672c616bebb68573
https://doi.org/10.22541/au.160253900.05254954/v1
https://doi.org/10.22541/au.160253900.05254954/v1
Background and aimsTLR4 is an important innate immune receptor that recognizes bacterial LPS, viral proteins and other pathogen associated molecular patterns (PAMPs). It is expressed on tissue-resident and immune cells. We previously proposed a model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::838c6f372c3c614558606912fa5cc09a
https://doi.org/10.1101/2021.08.11.455921
https://doi.org/10.1101/2021.08.11.455921
Autor:
Lauren J. Maskell, Laura Mele, Daniel J. Stuckey, Vishwanie Budhram-Mahadeo, Richard J. Heads, James Clark
Publikováno v:
Cell Death & Disease
Mele, L, Maskell, L J, Stuckey, D J, Clark, J E, Heads, R J & Budhram-mahadeo, V S 2019, ' The POU4F2/Brn-3b transcription factor is required for the hypertrophic response to angiotensin II in the heart ', Cell death & disease, vol. 10, no. 8, 621, pp. 621-638 . https://doi.org/10.1038/s41419-019-1848-y
Cell Death and Disease, Vol 10, Iss 8, Pp 1-18 (2019)
Mele, L, Maskell, L J, Stuckey, D J, Clark, J E, Heads, R J & Budhram-mahadeo, V S 2019, ' The POU4F2/Brn-3b transcription factor is required for the hypertrophic response to angiotensin II in the heart ', Cell death & disease, vol. 10, no. 8, 621, pp. 621-638 . https://doi.org/10.1038/s41419-019-1848-y
Cell Death and Disease, Vol 10, Iss 8, Pp 1-18 (2019)
Adult hearts respond to increased workload such as prolonged stress or injury, by undergoing hypertrophic growth. During this process, the early adaptive responses are important for maintaining cardiac output whereas at later stages, pathological res
Autor:
Michael R. Longman, Asvi Francois, Andrew K. Snabaitis, Michael J. Shattock, Jonathan Cowan, Ali Ryan, Olga Eleftheriadou, Brian E. Wadzinski, Richard J. Heads, Andrii Boguslavskyi
Publikováno v:
Basic Research in Cardiology
Cardiac physiology and hypertrophy are regulated by the phosphorylation status of many proteins, which is partly controlled by a poorly defined type 2A protein phosphatase-alpha4 intracellular signalling axis. Quantitative PCR analysis revealed that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275eb352c1b09c3cf51a9bcb2b49be51
https://eprints.kingston.ac.uk/id/eprint/38213/6/Eleftheriadou-O-38213-VoR.pdf
https://eprints.kingston.ac.uk/id/eprint/38213/6/Eleftheriadou-O-38213-VoR.pdf
Autor:
Rui F. D. S. Mesquita, Shahzia Anjum, Aida Valmaseda, Margaret A. Paul, Richard J. Heads, Rita I. Jabr, Michael S. Marber, Asvi Francois, Vishwanie Budhram-Mahadeo
Publikováno v:
Molecular and Cellular Biology. 34:574-594
The pathways which regulate resolution of inflammation and contribute to positive remodeling of the myocardium following injury are poorly understood. Here we show that protein kinase C epsilon (PKCε) cooperates with the phosphatase calcineurin (CN)
Autor:
Richard J. Heads, Stuart Bevan, Samuel Quek, Lihuan Liang, Clive Gentry, Aisah A. Aubdool, Susan D. Brain, Jessica Cheong, Chi Teng Vong, Salma Awal, Jennifer V. Bodkin, Elizabeth S. Fernandes
Publikováno v:
The FASEB Journal. 27:1664-1673
The underlying mechanisms of itch are poorly understood. We have investigated a model involving the chemoattractant leukotriene B₄ (LTB₄) that is up-regulated in common skin diseases. Intradermal injection of LTB4 (0.1 nmol/site) into female CD1
Publikováno v:
Cellular Signalling
The effect of differential signalling by IL-6 and leukaemia inhibitory factor (LIF) which signal by gp130 homodimerisation or LIFRβ/gp130 heterodimerisation on survival and hypertrophy was studied in neonatal rat cardiomyocytes. Both LIF and IL-6 [i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93235a8bbebefd66a650ae6e6d871f46
https://ora.ox.ac.uk/objects/uuid:4e2e7669-ae48-4111-a88e-61438fbd79ad
https://ora.ox.ac.uk/objects/uuid:4e2e7669-ae48-4111-a88e-61438fbd79ad