Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Richard J. Hargreaves"'
Publikováno v:
Neurobiology of Disease, Vol 61, Iss , Pp 32-38 (2014)
The goal of any early central nervous system (CNS) drug development program is always to test the mechanism and not the molecule in order to support additional research investments in late phase clinical trials. Confirmation that drugs reach their ta
Externí odkaz:
https://doaj.org/article/56e97bf2a1ad430aae73c1f8631836d0
Autor:
Manishkumar Patel, Alexa Gleason, Stacey O'Malley, Brett Connolly, Donna Suresch, John Virostko, Neil Phillips, Shu-An Lin, Tsing-Bau Chen, Michael Klimas, Richard J Hargreaves, Cyrille Sur, David L Williams, Alvin C Powers, Bohumil Bednar
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106693 (2014)
BACKGROUND:Type 2 diabetes results from failure of the β-cells to compensate for increased insulin demand due to abnormal levels of metabolic factors. The ob/ob(lep-/-) mouse has been extensively studied as an animal model of type 2 diabetes. Previo
Externí odkaz:
https://doaj.org/article/b351acae3b4d448490f7d29ab48b6176
Autor:
Haiying, Liu, Dan, Zhou, Maria L, Garcia, Martin G, Kohler, Xiaolan, Shen, Donald S, Williams, Michael T, Klimas, Richard J, Hargreaves, Gregory J, Kaczorowski
Publikováno v:
Journal of magnetic resonance imaging : JMRI. 41(6)
To characterize regional kidney sodium response by MRI following NKCC2 inhibition.Regional renal sodium signals were monitored noninvasively using (23) Na-MRI at 9.4T with a temporal resolution of 1.5 min in anesthetized rats (N = 14). A mild NKCC2 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::73861fe371533168be7ca4409562b4f4
https://pubmed.ncbi.nlm.nih.gov/25168165
https://pubmed.ncbi.nlm.nih.gov/25168165
Autor:
William A, Ball, Duane B, Snavely, Richard J, Hargreaves, Armin, Szegedi, Christopher, Lines, Scott A, Reines
Publikováno v:
Human psychopharmacology. 29(6)
Aprepitant is a neurokinin 1 receptor antagonist approved for prevention of chemotherapy-induced and post-operative nausea and vomiting. Early studies demonstrated promising antidepressant activity as monotherapy, although this was unsupported by sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7a04d92d45604b1d616c967da1d1f2be
https://pubmed.ncbi.nlm.nih.gov/25330122
https://pubmed.ncbi.nlm.nih.gov/25330122
Publikováno v:
Drug Discovery for Psychiatric Disorders ISBN: 9781849733656
Despite the successful introduction of treatments for many neuropsychiatric disorders, there remains an important unmet medical need. Successes to date generally represent a few well-established mechanisms of action, and newer drugs are largely incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4770f562b93a1770c88b03a621fdfc60
https://doi.org/10.1039/9781849734943-00574
https://doi.org/10.1039/9781849734943-00574
Autor:
Eric D, Hostetler, Sandra, Sanabria-Bohórquez, Waisi, Eng, Aniket D, Joshi, Shailendra, Patel, Raymond E, Gibson, Stacey, O'Malley, Stephen M, Krause, Christine, Ryan, Kerry, Riffel, Sheng, Bi, Osamu, Okamoto, Hiroshi, Kawamoto, Satoshi, Ozaki, Hisashi, Ohta, Tjibbe, de Groot, Guy, Bormans, Marleen, Depré, Jan, de Hoon, Inge, De Lepeleire, Tom, Reynders, Jacquelynn J, Cook, H Donald, Burns, Michael, Egan, William, Cho, Koen, van Laere, Richard J, Hargreaves
Publikováno v:
NeuroImage. 68
Antagonism of the central opioid receptor like-1 receptor (ORL1) has been implicated in cognition, and has been a focus of drug discovery efforts to ameliorate the cognitive deficits that remain during the stable treatment of schizophrenia with curre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1755afb6096e5d25e2a57127c213cab4
https://pubmed.ncbi.nlm.nih.gov/23238431
https://pubmed.ncbi.nlm.nih.gov/23238431
Autor:
Darrell R. Abernethy, Arthur J. Atkinson, William Budris, Ligong Chen, Jerry M. Collins, Charles E. Daniels, Robert L. Dedrick, David A. Flockhart, David M. Foster, Michael Fotis, Marilynn C. Frederiksen, Pamela D. Garzone, Kathleen M. Giacomini, Charles T. Gombar, Charles Grudzinskas, Richard J. Hargreaves, Nicholas H.G. Holford, Shiew-Mei Huang, Bridgette L. Jones, Gregory L. Kearns, Michael Klimas, S.W. Johnny Lau, Juan J.L. Lertora, Lawrence J. Lesko, Elizabeth S. Lowe, Sanford P. Markey, Raymond Miller, Paul F. Morrison, Diane R. Mould, Ameeta Parekh, Carl C. Peck, Scott R. Penzak, Sarah Robertson, Paul Rolan, Malcolm Rowland, Steven W. Ryder, Chandrahas G. Sahajwalla, Edward A. Sausville, Catherine S. Stika, Gregory M. Susla, Chris H. Takimoto, John N. Van Den Anker, Paolo Vicini, Joseph A. Ware, Ethan S. Weiner, Michael J. Wick, Janet Woodcock, Lei Zhang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46a186a2329e7600fe32122ed1ed210b
https://doi.org/10.1016/b978-0-12-385471-1.01002-3
https://doi.org/10.1016/b978-0-12-385471-1.01002-3
Drug development today needs to balance agility, speed, and risk in defining probability of success for molecules, mechanisms, and therapeutic concepts. New techniques such as fMRI promise to be part of a sequence that could transform drug developmen
Autor:
Koen, Van Laere, Guy, Bormans, Sandra M, Sanabria-Bohórquez, Tjibbe, de Groot, Patrick, Dupont, Inge, De Lepeleire, Jan, de Hoon, Luc, Mortelmans, Richard J, Hargreaves, John R, Atack, H Donald, Burns
Publikováno v:
Biological psychiatry. 64(2)
A novel, high-affinity (.7-2.0 nmol) compound that selectively activates the alpha2, alpha 3, and alpha 5 (but not alpha1) gamma-aminobutyric acid-A (GABA(A)) receptor subtypes, TPA023B (2',6-difluoro-5'-[3-(1-hydroxy-1-methylethyl) imidazo[1,2-b][1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2911da018088749916b072e7474dd597
https://pubmed.ncbi.nlm.nih.gov/18339360
https://pubmed.ncbi.nlm.nih.gov/18339360
Autor:
John R, Atack, Paul, Scott-Stevens, John S, Beech, Tim D, Fryer, Jessica L, Hughes, Marcel C, Cleij, Jean-Claude, Baron, John C, Clark, Richard J, Hargreaves, Franklin I, Aigbirhio
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 320(3)
The occupancy by lorazepam of the benzodiazepine binding site of rat brain GABA(A) receptors was compared when measured using either in vivo binding of [(3)H]flumazenil (8-fluoro 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carbo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::51dc1b7ee843ffe20792a4a2fb032f9f
https://pubmed.ncbi.nlm.nih.gov/17164474
https://pubmed.ncbi.nlm.nih.gov/17164474