Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Richard J. H. Wojcikiewicz"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Bcl-2-related ovarian killer, Bok, was first labeled “pro-apoptotic” due to its ability to cause cell death when over-expressed. However, it has become apparent that this is not a good name, since Bok is widely expressed in tissues other than ova
Externí odkaz:
https://doaj.org/article/70c64a9edf4f44c28d717b19aed2bf8b
Autor:
Caden G. Bonzerato, Katherine R. Keller, Jacqualyn J. Schulman, Xiaokong Gao, Laura M. Szczesniak, Richard J. H. Wojcikiewicz
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Controversy surrounds the cellular role of the Bcl-2 family protein Bok. On one hand, it has been shown that all endogenous Bok is bound to inositol 1,4,5-trisphosphate receptors (IP3Rs), while other data suggest that Bok can act as a pro-apoptotic m
Externí odkaz:
https://doaj.org/article/cba93f78ba4547379678ddeaf50679a3
Autor:
Yunzhou Dong, Yang Lee, Kui Cui, Ming He, Beibei Wang, Sudarshan Bhattacharjee, Bo Zhu, Tadayuki Yago, Kun Zhang, Lin Deng, Kunfu Ouyang, Aiyun Wen, Douglas B. Cowan, Kai Song, Lili Yu, Megan L. Brophy, Xiaolei Liu, Jill Wylie-Sears, Hao Wu, Scott Wong, Guanglin Cui, Yusuke Kawashima, Hiroyuki Matsumoto, Yoshio Kodera, Richard J. H. Wojcikiewicz, Sanjay Srivastava, Joyce Bischoff, Da-Zhi Wang, Klaus Ley, Hong Chen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Endothelial cell (EC) dysfunction and inflammation contribute to plaque destabilization in atherosclerosis, increasing the risk of thrombotic events. Here, the authors show that epsin promotes EC inflammation via a mechanism involving IP3R1 degradati
Externí odkaz:
https://doaj.org/article/348ebe71d77b44b0a5e82d323a1c1b08
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The function of the Bcl-2 family member Bok is currently enigmatic, with various disparate roles reported, including mediation of apoptosis, regulation of mitochondrial morphology, binding to inositol 1,4,5-trisphosphate receptors, and regulation of
Externí odkaz:
https://doaj.org/article/c22271909a5b4c88bafee70afb25fbd5
Publikováno v:
The Journal of biological chemistry. 298(6)
Long-term activation of inositol 1,4,5-trisphosphate receptors (IP
Autor:
Anucha, Sathanawongs, Katsuyoshi, Fujiwara, Tsubasa, Kato, Masahiko, Hirose, Maki, Kamoshita, Richard J H, Wojcikiewicz, Jan B, Parys, Junya, Ito, Naomi, Kashiwazaki
Publikováno v:
Animal science journal = Nihon chikusan Gakkaiho. 86(2)
At fertilization, inositol 1,4,5-trisphosphate receptor type 1 (IP3 R1) has a crucial role in Ca(2+) release in mammals. Expression levels, localization and phosphorylation of IP3 R1 are important for its function, but it still remains unclear which
Publikováno v:
Molecular cancer therapeutics. 3(10)
The proteasome inhibitor bortezomib is an emerging anticancer agent. Although the proteasome is clearly its locus of action, the early biochemical consequences of bortezomib treatment are poorly defined. Here, we show in cultured cells that bortezomi
Autor:
Richard J. H. Wojcikiewicz, Pauline R.M. Dobson, Barry L. Brown, Janet E. Merritt, John G. Baird
Publikováno v:
Bioscience Reports. 4:995-1000
A possible role for Ca 2+ and calmodulin in the action of growth-hormone-releasing factor (GHRF) was investigated. Low extracellular Ca2+ (
Publikováno v:
Biochimica et biophysica acta. 805(1)
Acetylcholine, oxotremorine and carbachol, compounds that exhibit muscarinic agonist activity, maximally inhibited basal prolactin secretion from GH3 cells by approx. 50% and intracellular cyclic AMP levels by approx. 20%. Both parameters were inhibi
Publikováno v:
Bioscience reports. 3(12)
Phosphatidylinositol (Ptd Ins) breakdown in response to thyrotropin-releasing hormone (TRH) was measured after preincubation of both normal rat anterior pituitary cells and GH3 turnout cells with [3H]inositol by the determination of [3H]inositol phos