Zobrazeno 1 - 10
of 203
pro vyhledávání: '"Richard J. Epstein"'
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/c00bf7ac823c4687b3cb924b71a4574e
Publikováno v:
PLoS ONE, Vol 18, Iss 4 (2023)
Intragenic CpG dinucleotides are tightly conserved in evolution yet are also vulnerable to methylation-dependent mutation, raising the question as to why these functionally critical sites have not been deselected by more stable coding sequences. We p
Externí odkaz:
https://doaj.org/article/d94db2c1f32b421ab9e19d69c81510aa
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Vast amounts of clinically relevant text-based variables lie undiscovered and unexploited in electronic medical records (EMR). To exploit this untapped resource, and thus facilitate the discovery of informative covariates from unstructured c
Externí odkaz:
https://doaj.org/article/beee489bea1846b2bde036d07648f143
Autor:
Yongzhong Zhao, Richard J. Epstein
Publikováno v:
Evolutionary Bioinformatics, Vol 2013, Iss 9, Pp 275-283 (2013)
Externí odkaz:
https://doaj.org/article/670f74ceca4b45afb307d925bc7d7898
Autor:
Richard J. Epstein
Publikováno v:
Cancer Informatics, Vol 2009, Iss 7, Pp 231-238 (2009)
Two problems now threaten the future of anticancer drug development: (i) the information explosion has made research into new target-specific drugs more duplication-prone, and hence less cost-efficient; and (ii) high-throughput genomic technologies h
Externí odkaz:
https://doaj.org/article/68c430ea2ec04f37bae1721fb1bd6e72
Autor:
Richard J. Epstein
Publikováno v:
Frontiers in Oncology, Vol 3 (2013)
The notion that targeted drugs can unplug gain-of-function tumor pathways has revitalized pharmaceutical research, but the survival benefits of this strategy have so far proven modest. A weakness of oncogene-blocking approaches is that they do not ad
Externí odkaz:
https://doaj.org/article/ff4a988bb0ea4f84a6e95c3b53b05924
Autor:
Richard J Epstein
Publikováno v:
Future Healthcare Journal. 10:85-89
Publikováno v:
JCO Clinical Cancer Informatics.
PURPOSE Predicting short-term mortality in patients with advanced cancer remains challenging. Whether digitalized clinical text can be used to build models to enhance survival prediction in this population is unclear. MATERIALS AND METHODS We conduct
Autor:
Richard J. Epstein
Publikováno v:
Tumor Biology. 43:159-176
The human TMPRSS2 gene is pathogenetically implicated in both coronaviral lung infection and prostate cancer, suggesting its potential as a drug target in both contexts. SARS-COV-2 spike polypeptides are primed by the host transmembrane TMPRSS2 prote
Publikováno v:
ecancermedicalscience. 15
Population aging is causing a demographic redistribution with implications for the future of healthcare. How will this affect oncology? First, there will be an overall rise in cancer affecting older adults, even though age-specific cancer incidences