Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Richard J. D'Andrea"'
Autor:
Mahmoud A. Bassal, Saumya E. Samaraweera, Kelly Lim, Brooks A. Bernard, Sheree Bailey, Satinder Kaur, Paul Leo, John Toubia, Chloe Thompson-Peach, Tran Nguyen, Kyaw Ze Ya Maung, Debora A. Casolari, Diana G. Iarossi, Ilaria S. Pagani, Jason Powell, Stuart Pitson, Siria Natera, Ute Roessner, Ian D. Lewis, Anna L. Brown, Daniel G. Tenen, Nirmal Robinson, David M. Ross, Ravindra Majeti, Thomas J. Gonda, Daniel Thomas, Richard J. D’Andrea
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Mitochondrial metabolism has been associated with tumourigenesis in acute myeloid leukaemia (AML) and currently considered as a potential therapeutic target. Here, the authors show, in patients with AML, that germline mutations in mitochondrial compl
Externí odkaz:
https://doaj.org/article/80997f20894a4c6ab09d4081863d91de
Autor:
Mahmoud A. Bassal, Saumya E. Samaraweera, Kelly Lim, Brooks A. Benard, Sheree Bailey, Satinder Kaur, Paul Leo, John Toubia, Chloe Thompson-Peach, Tran Nguyen, Kyaw Ze Ya Maung, Debora A. Casolari, Diana G. Iarossi, Ilaria S. Pagani, Jason Powell, Stuart Pitson, Siria Natera, Ute Roessner, Ian D. Lewis, Anna L. Brown, Daniel G. Tenen, Nirmal Robinson, David M. Ross, Ravindra Majeti, Thomas J. Gonda, Daniel Thomas, Richard J. D’Andrea
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/358e6495258e4f5ea0b4793e347e5337
Autor:
Nicole L. Wittwer, Gabriela Brumatti, Ceilidh Marchant, Jarrod J. Sandow, Melanie K. Pudney, Mara Dottore, Richard J. D'Andrea, Angel F. Lopez, Paul G. Ekert, Hayley S. Ramshaw
Publikováno v:
Blood Advances, Vol 1, Iss 15, Pp 1067-1079 (2017)
Abstract: High expression of the α chain of the interleukin-3 receptor (IL-3Rα; CD123) is a hallmark of acute myeloid leukemia (AML) leukemic stem cells (LSCs). Elevated CD123 expression is part of the diagnostic immunophenotyping of myeloid leukem
Externí odkaz:
https://doaj.org/article/06a3c0aaf2114e6a92cf5ba3f7cf2246
Autor:
Parvathy Venugopal, Sarah Moore, David M. Lawrence, Amee J. George, Ross D. Hannan, Sarah CE Bray, Luen Bik To, Richard J. D’Andrea, Jinghua Feng, Amanda Tirimacco, Alexandra L Yeoman, Chun Chun Young, Miriam Fine, Andreas W Schreiber, Christopher N. Hahn, Christopher Barnett, Ben Saxon, Hamish S. Scott
Publikováno v:
Haematologica, Vol 102, Iss 12 (2017)
Externí odkaz:
https://doaj.org/article/f04ac3bd09e04598b7941c51f67c050c
Autor:
Saumya E. Samaraweera, Tatjana Geukens, Debora A. Casolari, Tran Nguyen, Caitlyn Sun, Sheree Bailey, Sarah Moore, Jinghua Feng, Andreas W. Schreiber, Wendy T. Parker, Anna L. Brown, Carolyn Butcher, Peter G. Bardy, Michael Osborn, Hamish S. Scott, Dipti Talaulikar, Carolyn S. Grove, Christopher N. Hahn, Richard J. D'Andrea, David M. Ross
Publikováno v:
Pathology. 55:77-85
Refereed/Peer-reviewed The identification of a somatic mutation associated with myeloid malignancy is of diagnostic importance in myeloproliferative neoplasms (MPNs). Individuals with no mutation detected in common screening tests for variants in JAK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179f391d9840838f51051dcf2a1689a7
https://doi.org/10.1016/j.pathol.2022.05.015
https://doi.org/10.1016/j.pathol.2022.05.015
Autor:
Winnie L. Kan, Urmi Dhagat, Kerstin B. Kaufmann, Timothy R. Hercus, Tracy L. Nero, Andy GX. Zeng, John Toubia, Emma F. Barry, Sophie E. Broughton, Guillermo A. Gomez, Brooks A. Benard, Mara Dottore, Karen S. Cheung Tung Shing, Helena Boutzen, Saumya E. Samaraweera, Kaylene J. Simpson, Liqing Jin, Gregory J. Goodall, C. Glenn Begley, Daniel Thomas, Paul G. Ekert, Denis Tvorogov, Richard J. D'Andrea, John E. Dick, Michael W. Parker, Angel F. Lopez
Publikováno v:
Cancer Discovery.
Leukemia stem cells (LSC) possess distinct self-renewal and arrested differentiation properties that are responsible for disease emergence, therapy failure and recurrence in acute myeloid leukemia (AML). Despite AML displaying extensive biological an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc41572709858062712a31dec8e1417
https://doi.org/10.1158/2159-8290.cd-22-1396
https://doi.org/10.1158/2159-8290.cd-22-1396
Autor:
Ari M. Melnick, Martin Carroll, Christopher E. Mason, Elisabeth M. Paietta, Michael W. Becker, Richard J. D'Andrea, Hartmut Doehner, Constantine S. Mitsiades, Eugen Dhimolea, Kimihito C. Kawabata, Ceyda Durmaz, Christopher R. Chin, Tak C. Lee, Francine E. Garrett-Bakelman, Cem Meydan, Matt Teater, Meng Li, Cihangir Duy
Supplemental Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f5cfbb31b0403c58a8d2a79717db84
https://doi.org/10.1158/2159-8290.22540768.v1
https://doi.org/10.1158/2159-8290.22540768.v1
Autor:
Ari M. Melnick, Martin Carroll, Christopher E. Mason, Elisabeth M. Paietta, Michael W. Becker, Richard J. D'Andrea, Hartmut Doehner, Constantine S. Mitsiades, Eugen Dhimolea, Kimihito C. Kawabata, Ceyda Durmaz, Christopher R. Chin, Tak C. Lee, Francine E. Garrett-Bakelman, Cem Meydan, Matt Teater, Meng Li, Cihangir Duy
Network analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdbac20e3461c41b2232a959a17a0481
https://doi.org/10.1158/2159-8290.22540750
https://doi.org/10.1158/2159-8290.22540750
Autor:
Ari M. Melnick, Martin Carroll, Christopher E. Mason, Elisabeth M. Paietta, Michael W. Becker, Richard J. D'Andrea, Hartmut Doehner, Constantine S. Mitsiades, Eugen Dhimolea, Kimihito C. Kawabata, Ceyda Durmaz, Christopher R. Chin, Tak C. Lee, Francine E. Garrett-Bakelman, Cem Meydan, Matt Teater, Meng Li, Cihangir Duy
Patients with acute myeloid leukemia (AML) frequently relapse after chemotherapy, yet the mechanism by which AML reemerges is not fully understood. Herein, we show that primary AML cells enter a senescence-like phenotype following chemotherapy in vit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7665ad1a576a4b28fc5a709bc2cc4de1
https://doi.org/10.1158/2159-8290.c.6549469.v1
https://doi.org/10.1158/2159-8290.c.6549469.v1
Autor:
Paul M. Neilsen, David F. Callen, Jayesh Desai, David M. Thomas, Andreas Evdokiou, Richard J. D'Andrea, Michael P. Brown, Kristen Ho, Rebecca C. Haycox, Bronwen J. Mayo, Steve Chryssidis, Jim Manavis, Gelareh Farshid, Robert J. Whitfield, Michelle Perugini, David M. Lawrence, Andreas W. Schreiber, Mark T. Clayer, Susan J. Neuhaus, Kathleen I. Pishas
PDF file - 67K, TP53 pathway alterations do not mediate sarcoma cytostatic response to Nutlin-3a.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d47db383105720a35f84cd1d3813e03
https://doi.org/10.1158/0008-5472.22402151
https://doi.org/10.1158/0008-5472.22402151