Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Richard J. Coward"'
Autor:
Jennifer A. Hurcombe, Abigail C. Lay, Lan Ni, Alexandra F. Barrington, Jim R. Woodgett, Susan E. Quaggin, Gavin I. Welsh, Richard J. Coward
Publikováno v:
FASEB BioAdvances, Vol 1, Iss 8, Pp 498-510 (2019)
Abstract Podocytes are key cells in maintaining the integrity of the glomerular filtration barrier and preventing albuminuria. Glycogen synthase kinase 3 (GSK3) is a multi‐functional serine/threonine kinase existing as two distinct but related isof
Externí odkaz:
https://doaj.org/article/26255c42b79c4224a18d496e066cda30
Autor:
Salman B. Hosawi, Jonathan D. Humphries, Richard J. Coward, David Knight, Martin J. Humphries, Rachel Lennon
Publikováno v:
Wellcome Open Research, Vol 5 (2020)
Background: Insulin signalling contributes to diverse cellular activities including protein synthesis, proliferation and cell survival. Insulin resistance describes the inability of cells to activate the insulin signalling pathway effectively; leadin
Externí odkaz:
https://doaj.org/article/299739d9824f413e8ee98761ff715c1e
Autor:
Anne K. Mühlig, Lindsay S. Keir, Jana C. Abt, Hannah S. Heidelbach, Rachel Horton, Gavin I. Welsh, Catherine Meyer-Schwesinger, Christoph Licht, Richard J. Coward, Lars Fester, Moin A. Saleem, Jun Oh
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Podocytes are an important part of the glomerular filtration barrier and the key player in the development of proteinuria, which is an early feature of complement mediated renal diseases. Complement factors are mainly liver-born and present in circul
Externí odkaz:
https://doaj.org/article/4d77d2617eeb44fb91db2bbcf45b1acb
Autor:
Almudena G. Carrasco, Adriana Izquierdo-Lahuerta, Ángela M. Valverde, Lan Ni, Elena Flores-Salguero, Richard J. Coward, Gema Medina-Gómez
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1868:159329
Autor:
Paul S, Hartley, Richard J, Coward
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2067
Vertebrate podocytes are kidney glomerular cells critically required for normal renal filtration. To fulfill their role, podocytes form molecular sieves known as slit diaphragms that contribute to the glomerular filtration barrier. The disruption of
Autor:
Abigail C, Lay, Richard J, Coward
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2067
Podocytes are terminally differentiated, insulin-sensitive cells of the glomerular filtration barrier, with a central role in filtration barrier maintenance. Podocyte injury is one of the earliest features observed in diabetic nephropathy (DN) and pl
Autor:
Nicolas Bisson, Julie Ruston, Marie Jeansson, Rachel Vanderlaan, W Rod Hardy, Jianmei Du, Samer M Hussein, Richard J Coward, Susan E Quaggin, Tony Pawson
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50996 (2012)
The kidney filtration barrier is formed by the combination of endothelial cells, basement membrane and epithelial cells called podocytes. These specialized actin-rich cells form long and dynamic protrusions, the foot processes, which surround glomeru
Externí odkaz:
https://doaj.org/article/e339cb0cddbe4d3fb9f6740f6cf6b64d