Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Richard J. Colonno"'
Autor:
Qi Huang, Bin Zhou, Shi Liu, Yuhua Zong, Richard J. Colonno, Jinlin Hou, Jian Sun, Dawei Cai, Alexandre Mercier, Yaobo Wu, Haitao Guo
Publikováno v:
Hepatology (Baltimore, Md.)
Background and aims Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) plays a pivotal role in the establishment and persistence of HBV infection. Understanding the turnover time of preexisting cccDNA pools would be helpful in designing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ff7e779042b0f79f037fa2ae4fb5b1
https://doi.org/10.1002/hep.31240
https://doi.org/10.1002/hep.31240
Autor:
Kirk Henne, Yuhua Zong, Yi Zhou, Dawei Cai, Lida Guo, Ran Yan, Richard J. Colonno, Lichun Li, Alexandre Mercier, Ariel Tang, Qi Huang
Publikováno v:
Antimicrobial Agents and Chemotherapy
ABI-H0731, a first-generation hepatitis B virus (HBV) core protein inhibitor, has demonstrated effective antiviral activity in chronic hepatitis B (CHB) patients in a phase 1b clinical trial and is currently being further evaluated in phase 2 clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9db7bb553adf713ac1a456222ee9850
https://pubmed.ncbi.nlm.nih.gov/32868329
https://pubmed.ncbi.nlm.nih.gov/32868329
Autor:
Maissa El Raziky, Eric Ruby, Naglaa Allam, Hadeel Gamal El Deen, Sherine Helmy, Aliaa Sabry, Asmaa Gomaa, Mohamed S. Abdel-Hamid, M. K. Ashour, Hanaa Abdel-Maguid, Ola H. Nada, P. Vig, Gamal Esmat, Richard J. Colonno, Imam Waked, Nathaniel A. Brown, Mahmoud Abouelkhair, Tamer Elbaz
Publikováno v:
Journal of Hepatology. 68:53-62
Background & Aims Although treatment of hepatitis C virus (HCV) and HCV-genotype-4 (GT4) has become very effective, it remains very expensive, and affordable options are needed, especially in limited resource countries. The aim of this study was to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8ea0fefd66dd67bc6eed628a9b1410
https://doi.org/10.1016/j.jhep.2017.09.006
https://doi.org/10.1016/j.jhep.2017.09.006
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9195 (2010)
BACKGROUND: Entecavir (ETV) is a deoxyguanosine analog competitive inhibitor of hepatitis B virus (HBV) polymerase that exhibits delayed chain termination of HBV DNA. A high barrier to entecavir-resistance (ETVr) is observed clinically, likely due to
Externí odkaz:
https://doaj.org/article/d3184b0376a84ea99b5bba0418792a95
Autor:
Kosh Agarwal, William Sievert, Dong Joon Kim, Christian Schwabe, Qi Huang, Sang Hoon Ahn, Edward Gane, Young-Suk Lim, Eric Ruby, Kumar Visvanathan, Sandy Liaw, Man-Fung Yuen, Uri Lopatin, Richard J. Colonno, Ran Yan, Wendy Cheng
Publikováno v:
The lancet. Gastroenterologyhepatology. 5(2)
Summary Background Therapies with novel mechanisms of action against hepatitis B virus (HBV) infection are being explored with the goal of achieving a functional cure (sustained off-treatment response) without requiring lifelong therapy. We aimed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f68e4acc9b898fe7d97eac97a5c5812f
https://pubmed.ncbi.nlm.nih.gov/31711752
https://pubmed.ncbi.nlm.nih.gov/31711752
Autor:
Hong Ren, Tianying Zhang, Jidong Jia, Ningshao Xia, G. Renuka Kumar, Xiangbo Huang, Ruiyang Zhang, Pao-Chen Li, Jie Wang, Hui Zhuang, Tong Li, Tao Shen, Malcolm A. McCrae, Zhiliang Gao, Fengmin Lu, Xiangmei Chen, Jinlin Hou, Ran Chen, Quan Yuan, Qi Huang, Richard J. Colonno, Zhenzhen Zeng
Publikováno v:
Journal of Hepatology. 65(4):700-710
Background & Aims Hepatitis B virus (HBV) RNA in serum has recently been linked to efficacy and prognosis of chronic hepatitis B (CHB) treatment. This study explored the nature, origin, underlying mechanisms, and potential clinical significance of se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9dbcdf2e33f1c6657b138102a9c85d
Autor:
Zheng Yang, John D. Matiskella, Zhiwei Yin, Zhongxing Zhang, Tao Wang, John F. Kadow, Pin-Fang Lin, Hsu-Tso Ho, Richard J. Colonno, Yasu Ueda, Nicholas A. Meanwell, David R. Langley, Dawn D. Parker, Gregory Yamanaka, Yi-Fei Gong, Ming Zheng, Bradley C. Pearce
Publikováno v:
Journal of medicinal chemistry. 61(14)
The optimization of the 4-methoxy-6-azaindole series of HIV-1 attachment inhibitors (AIs) that originated with 1 to deliver temsavir (3, BMS-626529) is described. The most beneficial increases in potency and pharmacokinetic (PK) properties were attai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f366c79c2cc59e8a947151d9fef78a24
https://pubmed.ncbi.nlm.nih.gov/29920093
https://pubmed.ncbi.nlm.nih.gov/29920093
Autor:
Jinlin Hou, Bin Zhou, Dawei Cai, Shi Liu, Haitao Guo, Jian Sun, Richard J. Colonno, Qi Huang, Yaobo Wu, Yuhua Zong
Publikováno v:
Journal of Hepatology. 70:e258-e259
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8edc2b28dbd204c1061872f8fbe891f0
https://doi.org/10.1016/s0618-8278(19)30489-x
https://doi.org/10.1016/s0618-8278(19)30489-x
Autor:
Katia Alves, Marc Evanhcik, Christian Schwabe, Uri Lopatin, Sandy Liaw, Edward Gane, Richard J. Colonno, Eric Ruby
Publikováno v:
Journal of Hepatology. 70:e146-e147
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9638f1309ecf8d2468020e9c8d8a677
https://doi.org/10.1016/s0618-8278(19)30258-0
https://doi.org/10.1016/s0618-8278(19)30258-0
Autor:
Richard J. Colonno, Qi Huang, Eric Peng, Min Zhong, Meiyen Lau, Leping Li, Anja Huq, Ningwu Huang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:5731-5737
This Letter describes the discovery of a number of functionalized bisimidazoles bearing a cyclohexylphenyl, piperidylphenyl, or bicyclo[2,2,2]octylphenyl motif as HCV NS5A inhibitors. Compounds 2c, 4b and 6 have demonstrated low single-digit nM poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e815b035df34e9b55ba228cc89e5576
https://doi.org/10.1016/j.bmcl.2014.10.057
https://doi.org/10.1016/j.bmcl.2014.10.057