Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Richard J. Cenedella"'
Autor:
Richard J. Cenedella, Robert Jacob, Douglas Borchman, Daxin Tang, Amanda R. Neely, Abbas Samadi, R. Preston Mason, Patricia Sexton
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 7, Pp 1232-1241 (2004)
Induction of cataracts in experimental animals is a common toxic feature of oxidosqualene cyclase (OSC) inhibitors. U18666A has been shown to produce irreversible lens damage within a few weeks of treatment. Drug actions, besides reducing the availab
Externí odkaz:
https://doaj.org/article/c857a1a0d008499e83b021508b140f05
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 1, Pp 198-211 (2003)
Simvastatin rapidly induced cataracts in young Chbb:Thom (27) but not Sprague Dawley (SD) or Hilltop Wistar (HW) rats. Oral treatment for 14 but not 7 days committed CT rat lenses to cataract formation. The cholesterol to phospholipid molar ratio in
Externí odkaz:
https://doaj.org/article/55bb8b8d362944cca2c211164d73e924
Publikováno v:
Experimental Eye Research. 85:473-481
Recent studies of the distribution and relative concentration of caveolin-1 in fractions of bovine lens epithelial and fiber cells have led to the novel concept that caveolin-1 may largely exist as a peripheral membrane protein in some cells. Caveoli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9acd7c9c8e366e57d1dba6c19f106172
https://doi.org/10.1016/j.exer.2007.05.011
https://doi.org/10.1016/j.exer.2007.05.011
Publikováno v:
Lipids. 40:635-640
Treatment of animals or cells with the amphipathic tertiary amine U18666A {3beta-[2-(diethylamino) ethoxy]androst-5-en-17-one} provides models for several human diseases (e.g., cataracts, Niemann-Pick disease, and epilepsy). Although U18666A can inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cbc0ce15dbf578bfa57d6e59e353ab7
https://doi.org/10.1007/s11745-005-1426-9
https://doi.org/10.1007/s11745-005-1426-9
Autor:
Patricia S. Sexton, Douglas Borchman, Robert F. Jacob, R. Preston Mason, Abbas Samadi, Richard J. Cenedella, Amanda R. Neely, Daxin Tang
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 7, Pp 1232-1241 (2004)
Induction of cataracts in experimental animals is a common toxic feature of oxidosqualene cyclase (OSC) inhibitors. U18666A has been shown to produce irreversible lens damage within a few weeks of treatment. Drug actions, besides reducing the availab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3593a3f55497192e398a1755e6c084b5
https://doi.org/10.1194/jlr.m300469-jlr200
https://doi.org/10.1194/jlr.m300469-jlr200
Autor:
Richard J. Cenedella
Publikováno v:
Ophthalmic Research. 33:210-216
We investigated the possibility that sterols could covalently modify ocular lens cell proteins. Incubation of cultured bovine lens epithelial cells (BLEC) with 3H-cholesterol led to the labeling of a cytosolic protein of about 52 kD. Two-dimensional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::906bc53152d12d1ed2e8520ec1ba0381
https://doi.org/10.1159/000055672
https://doi.org/10.1159/000055672
Publikováno v:
Neurochemical Research. 25:685-694
Desmosterolosis is a rare, autosomal recessive, human disease characterized by multiple congenital anomalies in conjunction with grossly elevated levels of desmosterol and markedly reduced levels of cholesterol in all bodily tissues. Herein, we evalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3eaed34502d2bbb295e96c9bc0c76c0
https://doi.org/10.1023/a:1007519321917
https://doi.org/10.1023/a:1007519321917
Publikováno v:
Journal of Biological Chemistry. 274:31613-31618
The molecular structure of human ocular lens fiber cell plasma membranes was examined directly using small angle x-ray diffraction approaches. A distinct biochemical feature of these membranes is their high relative levels of free cholesterol; the mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b279d4290bcf90a0c70d31a87bee47
https://doi.org/10.1074/jbc.274.44.31613
https://doi.org/10.1074/jbc.274.44.31613
Publikováno v:
Experimental Eye Research. 66:559-567
The influence of cholesterol on the binding of alpha-crystallin to pure phospholipid membranes was studied. The rationale of this investigation stems from two unique aspects of human lens cells: an unusually high level of cholesterol in the membranes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b57f790a4be54ff7aad7b2ecfed925e
https://doi.org/10.1006/exer.1997.0467
https://doi.org/10.1006/exer.1997.0467
Autor:
Richard J. Cenedella
Publikováno v:
Experimental Eye Research. 65:63-72
The ocular lens must continuously synthesize the cholesterol required to support membrane formation for its life-long growth. The roles of transcriptional and posttranscriptional mechanisms in controlling 3-hydroxy-3-methylglutaryl coenzyme A reducta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492c902d241a57feccb36da90e6b96be
https://doi.org/10.1006/exer.1997.0310
https://doi.org/10.1006/exer.1997.0310