Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Richard J. Bram"'
Publikováno v:
JBMR Plus, Vol 6, Iss 10, Pp n/a-n/a (2022)
ABSTRACT Loss of bone mass and strength is a common problem of advanced age in humans. Defective bone is also a primary finding in osteogenesis imperfecta (OI), a genetic condition most commonly caused by autosomal dominant mutations in the type I co
Externí odkaz:
https://doaj.org/article/8a58df175b414147a090e1abfed07fb8
Autor:
Mayara Garcia de Mattos Barbosa, Adam R. Lefferts, Daniel Huynh, Hui Liu, Yu Zhang, Beverly Fu, Jenna Barnes, Milagros Samaniego, Richard J. Bram, Raif S. Geha, Ariella Shikanov, Eline T. Luning Prak, Evan A. Farkash, Jeffrey L. Platt, Marilia Cascalho
Publikováno v:
JCI Insight, Vol 6, Iss 17 (2021)
Host genes define the severity of inflammation and immunity but specific loci doing so are unknown. Here we show that TNF receptor superfamily member 13B (TNFRSF13B) variants, which enhance defense against certain pathogens, also control immune-media
Externí odkaz:
https://doaj.org/article/a070c085b731448ba55137aa11437ce9
Autor:
Haotian Zhao, Olivier Ayrault, Michael D. Talyor, Ulrich Schüller, Richard J. Bram, Kameswaran Surendran, Indra Chandrasekar, Stephanie Puget, Erliang Zeng, Xijin Ge, Alex H. Heglin, Xin Wang, Diane M. Maher, Slobodan Macura, Justin H. Gundelach, Amanda M. Schaefer, Antoine Forget, A. Sorana Morrissy, Hasitha Premathilake, Laure Bihannic, Samuel D.R. Dooyema, Katie B. Grausam
This file provides illustration of supplemental experimental results and explanation of data presented. Supplemental Figure 1 Analysis of gene expression in CAG-A1Z transgenic mice. Supplemental Figure 2 Normal cerebellar development in Atoh1 transge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646048ca6c3e852d7d38f68afc44e3bf
https://doi.org/10.1158/0008-5472.22415009.v1
https://doi.org/10.1158/0008-5472.22415009.v1
Autor:
Haotian Zhao, Olivier Ayrault, Michael D. Talyor, Ulrich Schüller, Richard J. Bram, Kameswaran Surendran, Indra Chandrasekar, Stephanie Puget, Erliang Zeng, Xijin Ge, Alex H. Heglin, Xin Wang, Diane M. Maher, Slobodan Macura, Justin H. Gundelach, Amanda M. Schaefer, Antoine Forget, A. Sorana Morrissy, Hasitha Premathilake, Laure Bihannic, Samuel D.R. Dooyema, Katie B. Grausam
This section provides detailed information on experimental procedures and data analysis methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c8eb04cb0166aa4efb32d8f483115f7
https://doi.org/10.1158/0008-5472.22415024.v1
https://doi.org/10.1158/0008-5472.22415024.v1
Autor:
Haotian Zhao, Olivier Ayrault, Michael D. Talyor, Ulrich Schüller, Richard J. Bram, Kameswaran Surendran, Indra Chandrasekar, Stephanie Puget, Erliang Zeng, Xijin Ge, Alex H. Heglin, Xin Wang, Diane M. Maher, Slobodan Macura, Justin H. Gundelach, Amanda M. Schaefer, Antoine Forget, A. Sorana Morrissy, Hasitha Premathilake, Laure Bihannic, Samuel D.R. Dooyema, Katie B. Grausam
Medulloblastoma arising from the cerebellum is the most common pediatric brain malignancy, with leptomeningeal metastases often present at diagnosis and recurrence associated with poor clinical outcome. In this study, we used mouse medulloblastoma mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e11fa39ef5c0deb112ac2eb8a77e9b8
https://doi.org/10.1158/0008-5472.c.6509144.v1
https://doi.org/10.1158/0008-5472.c.6509144.v1
Autor:
Haotian Zhao, Olivier Ayrault, Michael D. Talyor, Ulrich Schüller, Richard J. Bram, Kameswaran Surendran, Indra Chandrasekar, Stephanie Puget, Erliang Zeng, Xijin Ge, Alex H. Heglin, Xin Wang, Diane M. Maher, Slobodan Macura, Justin H. Gundelach, Amanda M. Schaefer, Antoine Forget, A. Sorana Morrissy, Hasitha Premathilake, Laure Bihannic, Samuel D.R. Dooyema, Katie B. Grausam
This table provides sequence information for primers and probes used in RT-qPCR.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b996e9b930e83755a339e0f01e6bf9
https://doi.org/10.1158/0008-5472.22415021.v1
https://doi.org/10.1158/0008-5472.22415021.v1
Autor:
Haotian Zhao, Olivier Ayrault, Michael D. Talyor, Ulrich Schüller, Richard J. Bram, Kameswaran Surendran, Indra Chandrasekar, Stephanie Puget, Erliang Zeng, Xijin Ge, Alex H. Heglin, Xin Wang, Diane M. Maher, Slobodan Macura, Justin H. Gundelach, Amanda M. Schaefer, Antoine Forget, A. Sorana Morrissy, Hasitha Premathilake, Laure Bihannic, Samuel D.R. Dooyema, Katie B. Grausam
This table provide supplemental information on the results of ChIP-seq and gene expression analyses of primary and spinal metastatic tumors in MAP mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856331407f22976062816d2b1b7d120a
https://doi.org/10.1158/0008-5472.22415012.v1
https://doi.org/10.1158/0008-5472.22415012.v1
Glioblastoma multiforme is an aggressive, treatment-refractory type of brain tumor for which effective therapeutic targets remain important to identify. Here, we report that cyclophilin B (CypB), a prolyl isomerase residing in the endoplasmic reticul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55575f92d3157916d29b1c1eee756384
https://doi.org/10.1158/0008-5472.c.6505772
https://doi.org/10.1158/0008-5472.c.6505772
PDF file - 1026K, Figure S1. Pharmacological inhibition of Cyclophilin B reduces glioblastoma cell survival. Figure S2. Inhibition of MAPK signaling prevents CypB knockdown-induced senescence. Figure S3. Cyclophilin B controls p53 expression. Figure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1c527965d9752a4f712acf93bc8130
https://doi.org/10.1158/0008-5472.22401137.v1
https://doi.org/10.1158/0008-5472.22401137.v1