Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Richard J. Franklin"'
Autor:
Yalan Tang, Jean M. H. van den Elsen, Phil Stanley, Maisem Laabei, Toska Wonfor, Callum Joyce, Richard D. Taylor, Kenneth Saunders, Robert J. Broadbridge, Alastair D. G. Lawson, Sebastian Kelm, Gregory Bogle, Matthew Duncan Selby, Douangsone Vadysirisack, Alex Macpherson, Kevin Brady, Jiye Shi, Richard J. Franklin, James R. Birtley, John Horton, Adam Hold, Monika-Sarah E. D. Schulze
Cysteine-rich knob domains found in the ultralong complementarity determining regions of a subset of bovine antibodies, are capable of functioning autonomously as 3-6 kDa peptides. While they can be expressed recombinantly in cellular systems, in thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979d9fb522645065a68d3d469815cd27
https://doi.org/10.1101/2021.06.16.448769
https://doi.org/10.1101/2021.06.16.448769
Autor:
Adnan Khan, Farnaz Fallah-Arani, Bart Vanderhoydonck, Judi Charlotte Neuss, Sarah Malcolm, Alfred Lammens, Richard J. Franklin, Lindsay K. Shuttleworth, Qiuya Huang, Jamie Henshall, Daniel James Ford, Mi-Yeon Jang, Shengqiao Li, Helen Tracey Horsley, Daniel Christopher Brookings, Mark Waer, Rodger A. Allen, Payne Andrew Charles, Yuan Lin, Eleanor Ward, Tom Ceska, Piet Herdewijn, Mark Jairaj, James Thomas Reuberson, Stefan Steinbacher, Mark Daniel Calmiano, Carl Brendan Doyle, Ling-Jie Gao, William R. Pitt, Jean Herman, Martin Augustin, Thierry Louat, Anant Ramrao Ghawalkar
Publikováno v:
Journal of medicinal chemistry. 61(15)
The primary target of a novel series of immunosuppressive 7-piperazin-1-ylthiazolo[5,4- d]pyrimidin-5-amines was identified as the lipid kinase, PI4KIIIβ. Evaluation of the series highlighted their poor solubility and unwanted off-target activities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb0c4c0435f5fee9f6100cde0751d5a
https://pubmed.ncbi.nlm.nih.gov/29952567
https://pubmed.ncbi.nlm.nih.gov/29952567
Autor:
John Maddock, Mary F. Mahon, Kieran C. Molloy, Graham R. Evans, Varinder K. Aggarwal, Martin J. Rice, Andrew Peter Thomas, Richard J. Franklin
Publikováno v:
The Journal of Organic Chemistry. 60:2174-2182
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0be11610693d2d92ec7b63f3648f3f8
https://doi.org/10.1021/jo00112a042
https://doi.org/10.1021/jo00112a042
Autor:
Mark D. Carr, Mariusz Muzylak, David McMillan, Richard J. Franklin, Vaclav Veverka, Daniel Christopher Brookings, Joanne E. Compson, Kelly Le Riche, Laura Ellen Newnham, Carl Brendan Doyle, Thomas A Ceska, Rachael Garlish, James Petrie Turner, Jiye Shi, Bernadette Sweeney, Alistair James Henry, Patrick M. Slocombe, Jeffery Kennedy, Gill Holdsworth, Martyn K. Robinson
Publikováno v:
The Journal of biological chemistry. 287(32)
LRP5 and LRP6 are proteins predicted to contain four six-bladed β-propeller domains and both bind the bone-specific Wnt signaling antagonist sclerostin. Here, we report the crystal structure of the amino-terminal region of LRP6 and using NMR show th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264cb99223c5808bb96a9f6cf30f0c4e
https://pubmed.ncbi.nlm.nih.gov/22696217
https://pubmed.ncbi.nlm.nih.gov/22696217
Autor:
Kieran C. Molloy, Varinder K. Aggarwal, Ian W. Davies, Richard J. Franklin, Mary F. Mahon, John Maddock
Publikováno v:
ChemInform. 22
trans-1,3-Dithiane 1,3-dioxide, prepared by stereoselective oxidation of 1,3-dithiane has been found to be thermodynamically more stable than the cis-isomer by equilibration studies using N2O4 and has been found to undergo highly selective (20 : 1) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57ab2b514e03edd089e59a3454d780e5
https://doi.org/10.1002/chin.199124172
https://doi.org/10.1002/chin.199124172
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73d123c94b2212e0fcfb16eb3e0ee23a
https://doi.org/10.1002/chin.199231200
https://doi.org/10.1002/chin.199231200
Autor:
Kieran C. Molloy, Varinder K. Aggarwal, Mary F. Mahon, Richard J. Franklin, Ian W. Davies, John Maddock
Publikováno v:
ChemInform. 26
Oxidation of 1,3-dithiane has been carried out using eight different oxidants under several different reaction conditions. The most favourable conditions for obtaining the required trans-1,3-dithiane 1,3-dioxide were to use either MCPBA in Et2O or Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a93934c1babd4e4bb20eda5dc33e6632
https://doi.org/10.1002/chin.199508114
https://doi.org/10.1002/chin.199508114
Publikováno v:
ChemInform. 25
trans-1,3-Dithiane-1,3-dioxide reacts with high diastereoselectivity with aromatic aldehydes and the 1,3-dithiane-1,3-dioxide moiety can be easily converted to a thiolester without racemisation by carrying out a Pummerer reaction; the thiolester is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efa3a34e8e1b9b47ef56fe28e70448e9
https://doi.org/10.1002/chin.199449141
https://doi.org/10.1002/chin.199449141
Autor:
Varinder K. Aggarwal, Mary F. Mahon, Martin J. Rice, Andrew Peter Thomas, John Maddock, Kieran C. Molloy, Richard J. Franklin, Graham R. Evans
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::008f571aa543eede5e9f289704c5624f
https://doi.org/10.1002/chin.199534174
https://doi.org/10.1002/chin.199534174
Autor:
John Robert Porter, Mark James Batchelor, Fabien Lecomte, Christoph Meier, Jean Keyaerts, Lloyd King, Jose M. Gascon-Simorte, James Thomas Reuberson, Alison Maloney, Kelly Le Riche, Jean Delgado, Mark Daniel Calmiano, Bénédicte Lallemand, Simon Lumb, Anne Marie Foley, Richard J. Franklin, Helen Edwards
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(10)
A series of 4-azaindole inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and series optimisation was performed on the basis of this structure. Future directions for series development ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3985a39d17773e1b2ec299ad573ae58
https://pubmed.ncbi.nlm.nih.gov/19369077
https://pubmed.ncbi.nlm.nih.gov/19369077