Zobrazeno 1 - 10
of 262
pro vyhledávání: '"Richard J Youle"'
Publikováno v:
PLoS Genetics, Vol 19, Iss 7, p e1010828 (2023)
The early pathogenesis and underlying molecular causes of motor neuron degeneration in Parkinson's Disease (PD) remains unresolved. In the model organism Drosophila melanogaster, loss of the early-onset PD gene parkin (the ortholog of human PRKN) res
Externí odkaz:
https://doaj.org/article/735bdcfb4eb74d07adfba1123831897b
Autor:
Nicholas R Ader, Patrick C Hoffmann, Iva Ganeva, Alicia C Borgeaud, Chunxin Wang, Richard J Youle, Wanda Kukulski
Publikováno v:
eLife, Vol 8 (2019)
During apoptosis, Bcl-2 proteins such as Bax and Bak mediate the release of pro-apoptotic proteins from the mitochondria by clustering on the outer mitochondrial membrane and thereby permeabilizing it. However, it remains unclear how outer membrane o
Externí odkaz:
https://doaj.org/article/03350d01eeaf4eab9e7aff73e995dd05
Autor:
Koji Yamano, Chunxin Wang, Shireen A Sarraf, Christian Münch, Reika Kikuchi, Nobuo N Noda, Yohei Hizukuri, Masato T Kanemaki, Wade Harper, Keiji Tanaka, Noriyuki Matsuda, Richard J Youle
Publikováno v:
eLife, Vol 7 (2018)
Damaged mitochondria are selectively eliminated by mitophagy. Parkin and PINK1, gene products mutated in familial Parkinson’s disease, play essential roles in mitophagy through ubiquitination of mitochondria. Cargo ubiquitination by E3 ubiquitin li
Externí odkaz:
https://doaj.org/article/b87dc833f3524dbf8e78bd09150a1267
Publikováno v:
eLife, Vol 3 (2014)
Damaged mitochondria can be selectively eliminated by mitophagy. Although two gene products mutated in Parkinson’s disease, PINK1, and Parkin have been found to play a central role in triggering mitophagy in mammals, how the pre-autophagosomal isol
Externí odkaz:
https://doaj.org/article/972fb1610f8041a6b9bf131c88c70b77
Autor:
Catherine L Nezich, Richard J Youle
Publikováno v:
eLife, Vol 2 (2013)
Ensuring that mitochondrial DNA is successfully divided between daughter mitochondria involves a complex series of interactions with the endoplasmic reticulum and a variety of enzymes.
Externí odkaz:
https://doaj.org/article/7a37294cb6144c4ba3c9f342a7b86f05
Autor:
Derek P Narendra, Seok Min Jin, Atsushi Tanaka, Der-Fen Suen, Clement A Gautier, Jie Shen, Mark R Cookson, Richard J Youle
Publikováno v:
PLoS Biology, Vol 8, Iss 1, p e1000298 (2010)
Loss-of-function mutations in PINK1 and Parkin cause parkinsonism in humans and mitochondrial dysfunction in model organisms. Parkin is selectively recruited from the cytosol to damaged mitochondria to trigger their autophagy. How Parkin recognizes d
Externí odkaz:
https://doaj.org/article/8e127fc52b86486593b7ee294d8b508c
Autor:
François Le Guerroué, Eric N. Bunker, William M. Rosencrans, Jack T. Nguyen, Mohammed A. Basar, Achim Werner, Tsui-Fen Chou, Chunxin Wang, Richard J. Youle
Publikováno v:
Molecular Cell. 83:927-941.e8
Autor:
Richard J. Youle, Koji Yamano
Publikováno v:
Autophagy
article-version (VoR) Version of Record
article-version (VoR) Version of Record
PINK1 and PRKN, proteins mutated in Parkinson disease, selectively amplify ubiquitin signals on damaged mitochondria for elimination via mitophagy. Because all five macroautophagy/autophagy receptors in mammals possess domains binding to ubiquitin an
Autor:
Yaakov Maman, Michael E. Ward, Heather Baldwin, Eunice Domínguez-Martín, Jennifer Lippincott-Schwartz, Shireen A. Sarraf, Gil Kanfer, Kory R. Johnson, Martin Kampmann, Richard J. Youle
Publikováno v:
The Journal of Cell Biology
Kanfer et al. develop a pooled CRISPRi screening method to identify genes regulating intracellular protein localization, organelle morphology or other subcellular phenotypes. The method uses machine learning to identify genetically altered cells, a p
Autor:
Shireen A. Sarraf, Michael E. Ward, Lynne A. Holtzclaw, Richard J. Youle, Hetal V. Shah, Gil Kanfer, Alicia M. Pickrell
Publikováno v:
Mol Cell
Summary Protein aggregates disrupt cellular homeostasis, causing toxicity linked to neurodegeneration. Selective autophagic elimination of aggregates is critical to protein quality control, but how aggregates are selectively targeted for degradation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9639dca7754c89b981679202a32049f6
https://europepmc.org/articles/PMC7771836/
https://europepmc.org/articles/PMC7771836/