Zobrazeno 1 - 10
of 453
pro vyhledávání: '"Richard J Youle"'
Publikováno v:
PLoS Genetics, Vol 19, Iss 7, p e1010828 (2023)
The early pathogenesis and underlying molecular causes of motor neuron degeneration in Parkinson's Disease (PD) remains unresolved. In the model organism Drosophila melanogaster, loss of the early-onset PD gene parkin (the ortholog of human PRKN) res
Externí odkaz:
https://doaj.org/article/735bdcfb4eb74d07adfba1123831897b
Autor:
Shiori Sekine, Richard J. Youle
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-12 (2018)
Abstract Insights from inherited forms of parkinsonism suggest that insufficient mitophagy may be one etiology of the disease. PINK1/Parkin-dependent mitophagy, which helps maintain a healthy mitochondrial network, is initiated by activation of the P
Externí odkaz:
https://doaj.org/article/1570c72145fe4492bc67a4134ae7a77d
Autor:
Shireen A. Sarraf, Dionisia P. Sideris, Nikolaos Giagtzoglou, Lina Ni, Mark W. Kankel, Anindya Sen, Lauren E. Bochicchio, Chiu-Hui Huang, Samuel C. Nussenzweig, Stuart H. Worley, Paul D. Morton, Spyros Artavanis-Tsakonas, Richard J. Youle, Alicia M. Pickrell
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 225-235.e5 (2019)
Summary: PINK1 and Parkin are established mediators of mitophagy, the selective removal of damaged mitochondria by autophagy. PINK1 and Parkin have been proposed to act as tumor suppressors, as loss-of-function mutations are correlated with enhanced
Externí odkaz:
https://doaj.org/article/bf4f769d38864797a92246e82ed02857
Autor:
Nicholas R Ader, Patrick C Hoffmann, Iva Ganeva, Alicia C Borgeaud, Chunxin Wang, Richard J Youle, Wanda Kukulski
Publikováno v:
eLife, Vol 8 (2019)
During apoptosis, Bcl-2 proteins such as Bax and Bak mediate the release of pro-apoptotic proteins from the mitochondria by clustering on the outer mitochondrial membrane and thereby permeabilizing it. However, it remains unclear how outer membrane o
Externí odkaz:
https://doaj.org/article/03350d01eeaf4eab9e7aff73e995dd05
Autor:
Colby L Samstag, Jake G Hoekstra, Chiu-Hui Huang, Mark J Chaisson, Richard J Youle, Scott R Kennedy, Leo J Pallanck
Publikováno v:
PLoS Genetics, Vol 14, Iss 11, p e1007805 (2018)
Mitochondrial DNA (mtDNA) mutations cause severe maternally inherited syndromes and the accumulation of somatic mtDNA mutations is implicated in aging and common diseases. However, the mechanisms that influence the frequency and pathogenicity of mtDN
Externí odkaz:
https://doaj.org/article/6cb3f3c6918441c4bd5d6df785a1fabc
Autor:
Koji Yamano, Chunxin Wang, Shireen A Sarraf, Christian Münch, Reika Kikuchi, Nobuo N Noda, Yohei Hizukuri, Masato T Kanemaki, Wade Harper, Keiji Tanaka, Noriyuki Matsuda, Richard J Youle
Publikováno v:
eLife, Vol 7 (2018)
Damaged mitochondria are selectively eliminated by mitophagy. Parkin and PINK1, gene products mutated in familial Parkinson’s disease, play essential roles in mitophagy through ubiquitination of mitochondria. Cargo ubiquitination by E3 ubiquitin li
Externí odkaz:
https://doaj.org/article/b87dc833f3524dbf8e78bd09150a1267
Publikováno v:
Cell Reports, Vol 12, Iss 5, Pp 743-751 (2015)
Membrane trafficking and spinogenesis contribute significantly to changes in synaptic strength during development and in various paradigms of synaptic plasticity. GTPases of the dynamin family are key players regulating membrane trafficking. Here, we
Externí odkaz:
https://doaj.org/article/da6b07987af34f8cbb65c3dfda3e45e8
Autor:
François Le Guerroué, Eric N. Bunker, William M. Rosencrans, Jack T. Nguyen, Mohammed A. Basar, Achim Werner, Tsui-Fen Chou, Chunxin Wang, Richard J. Youle
Publikováno v:
Molecular Cell. 83:927-941.e8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe1f015ed2333ce7d08b4bdc95d77e85
https://doi.org/10.1016/j.molcel.2023.02.023
https://doi.org/10.1016/j.molcel.2023.02.023
Autor:
Richard J. Youle, Koji Yamano
Publikováno v:
Autophagy
article-version (VoR) Version of Record
article-version (VoR) Version of Record
PINK1 and PRKN, proteins mutated in Parkinson disease, selectively amplify ubiquitin signals on damaged mitochondria for elimination via mitophagy. Because all five macroautophagy/autophagy receptors in mammals possess domains binding to ubiquitin an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f285a655177efb24328ae64d2ad217e
http://europepmc.org/articles/PMC7595642
http://europepmc.org/articles/PMC7595642
Publikováno v:
eLife, Vol 3 (2014)
Damaged mitochondria can be selectively eliminated by mitophagy. Although two gene products mutated in Parkinson’s disease, PINK1, and Parkin have been found to play a central role in triggering mitophagy in mammals, how the pre-autophagosomal isol
Externí odkaz:
https://doaj.org/article/972fb1610f8041a6b9bf131c88c70b77