Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Richard J Poole"'
Autor:
Laura Molina-García, Carla Lloret-Fernández, Steven J Cook, Byunghyuk Kim, Rachel C Bonnington, Michele Sammut, Jack M O'Shea, Sophie PR Gilbert, David J Elliott, David H Hall, Scott W Emmons, Arantza Barrios, Richard J Poole
Publikováno v:
eLife, Vol 9 (2020)
Sexually dimorphic behaviours require underlying differences in the nervous system between males and females. The extent to which nervous systems are sexually dimorphic and the cellular and molecular mechanisms that regulate these differences are onl
Externí odkaz:
https://doaj.org/article/c207abe9f7e4486c9e843b9956c3ab2f
Autor:
Filipe Marques, Gabriella Saro, Andrei-Stefan Lia, Richard J Poole, Laurent Falquet, Dominique A Glauser
Publikováno v:
PLoS Genetics, Vol 15, Iss 12, p e1008509 (2019)
Understanding how the nervous system bridges sensation and behavior requires the elucidation of complex neural and molecular networks. Forward genetic approaches, such as screens conducted in C. elegans, have successfully identified genes required to
Externí odkaz:
https://doaj.org/article/c456298014ab4177baf46c58ec451b04
Autor:
Katherine J Turner, Jacqueline Hoyle, Leonardo E Valdivia, Kara L Cerveny, Wendy Hart, Maryam Mangoli, Robert Geisler, Michele Rees, Corinne Houart, Richard J Poole, Stephen W Wilson, Gaia Gestri
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0211073 (2019)
Through forward genetic screening for mutations affecting visual system development, we identified prominent coloboma and cell-autonomous retinal neuron differentiation, lamination and retinal axon projection defects in eisspalte (ele) mutant zebrafi
Externí odkaz:
https://doaj.org/article/c92a0a24d7ac4e7e901688861ff7db0b
Autor:
Nadin Memar, Ryan Sherrard, Aditya Sethi, Carla Lloret Fernandez, Henning Schmidt, Eric J. Lambie, Richard J. Poole, Ralf Schnabel, Barbara Conradt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract We report that the eukaryotic replicative helicase CMG (Cdc45-MCM-GINS) is required for differential gene expression in cells produced by asymmetric cell divisions in C. elegans. We found that the C. elegans CMG component, PSF-2 GINS2, is ne
Externí odkaz:
https://doaj.org/article/6eec216ab0a34138b88af544db4362f7
Autor:
Dimitris Katsanos, Sneha L Koneru, Lamia Mestek Boukhibar, Nicola Gritti, Ritobrata Ghose, Peter J Appleford, Maria Doitsidou, Alison Woollard, Jeroen S van Zon, Richard J Poole, Michalis Barkoulas
Publikováno v:
PLoS Biology, Vol 15, Iss 11, p e2002429 (2017)
Biological systems are subject to inherent stochasticity. Nevertheless, development is remarkably robust, ensuring the consistency of key phenotypic traits such as correct cell numbers in a certain tissue. It is currently unclear which genes modulate
Externí odkaz:
https://doaj.org/article/6277508cb47d427395d2628aabc8f068
Autor:
Jenea M. Bin, Daumante Suminaite, Silvia K. Benito-Kwiecinski, Linde Kegel, Maria Rubio-Brotons, Jason J. Early, Daniel Soong, Matthew R. Livesey, Richard J. Poole, David A. Lyons
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Axon diameter influences the conduction properties of myelinated axons, both directly, and indirectly through effects on myelin. However, we have limited understanding of mechanisms controlling axon diameter growth in the central nervous sys
Externí odkaz:
https://doaj.org/article/2b19a064e0d044c39dccbbb7e1cd2aee
Publikováno v:
PLoS Genetics, Vol 7, Iss 6, p e1002109 (2011)
One of the central goals of developmental neurobiology is to describe and understand the multi-tiered molecular events that control the progression of a fertilized egg to a terminally differentiated neuron. In the nematode Caenorhabditis elegans, the
Externí odkaz:
https://doaj.org/article/56d1bfcad5084657a37ec8fadd03dd27
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e15435 (2010)
Whole-genome sequencing (WGS) is becoming a fast and cost-effective method to pinpoint molecular lesions in mutagenized genetic model systems, such as Caenorhabditis elegans. As mutagenized strains contain a significant mutational load, it is often s
Externí odkaz:
https://doaj.org/article/d0d24881e43245fbb0f51de91cce0f75
Autor:
Jenea M Bin, Daumante Suminaite, Silvia K. Benito-Kwiecinski, Linde Kegel, Maria Rubio-Brotons, Jason J Early, Daniel Soong, Matthew R Livesey, Richard J Poole, David A Lyons
SummaryCentral nervous system neurons have axons that vary over 100-fold in diameter. This diversity contributes to the regulation of myelination and conduction velocity along axons, which is critical for proper nervous system function. Despite this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01b97ba00dd43875240ad53fca9b53ad
https://doi.org/10.1101/2023.05.19.541431
https://doi.org/10.1101/2023.05.19.541431
Publikováno v:
Developmental Biology
Strikingly, epithelial morphogenesis remains incomplete at the end of C. elegans embryonic development; newly hatched larvae undergo extensive remodelling of their ventral epidermis during the first larval stage (L1), when newly-born epidermal cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2874708f787db4ded0d0a05e5d3b02
https://doi.org/10.1016/j.ydbio.2020.01.001
https://doi.org/10.1016/j.ydbio.2020.01.001