Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Richard J Piercy"'
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239467 (2020)
Dystrophin plays a vital role in maintaining muscle health, yet low mRNA expression, lengthy transcription time and the limitations of traditional in-situ hybridization (ISH) methodologies mean that the dynamics of dystrophin transcription remain poo
Externí odkaz:
https://doaj.org/article/5542f3e3218e4b2f88c55ac1cc7da0db
Autor:
Annette M McCoy, Samantha K Beeson, Carl-Johan Rubin, Leif Andersson, Paul Caputo, Sigrid Lykkjen, Alison Moore, Richard J Piercy, James R Mickelson, Molly E McCue
Publikováno v:
PLoS Genetics, Vol 15, Iss 5, p e1008146 (2019)
Several horse breeds have been specifically selected for the ability to exhibit alternative patterns of locomotion, or gaits. A premature stop codon in the gene DMRT3 is permissive for "gaitedness" across breeds. However, this mutation is nearly fixe
Externí odkaz:
https://doaj.org/article/e7fad45d81574548aee1fced35ca20c8
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0199521 (2018)
Hypoglycin A (HGA) toxicity, following ingestion of material from certain plants, is linked to an acquired multiple acyl-CoA dehydrogenase deficiency known as atypical myopathy, a commonly fatal form of equine rhabdomyolysis seen worldwide. Whilst so
Externí odkaz:
https://doaj.org/article/2e96b6730bbb46849238e60ccf6761ac
Autor:
Marta Fernandez-Fuente, Cesare M Terracciano, Pilar Martin-Duque, Susan C Brown, Georges Vassaux, Richard J Piercy
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105971 (2014)
Dysfunctional skeletal muscle calcium homeostasis plays a central role in the pathophysiology of several human and animal skeletal muscle disorders, in particular, genetic disorders associated with ryanodine receptor 1 (RYR1) mutations, such as malig
Externí odkaz:
https://doaj.org/article/a4ee4f56c50941afb01288455300929e
Publikováno v:
Royal Society Open Science, Vol 11, Iss 7 (2024)
Objective assessment of activity via accelerometry can provide valuable insights into dog health and welfare. Common activity metrics involve using acceleration cut-points to group data into intensity categories and reporting the time spent in each c
Externí odkaz:
https://doaj.org/article/d7252d61b0b243fe93a50c736ca9c486
Autor:
Jessica L Petersen, James R Mickelson, E Gus Cothran, Lisa S Andersson, Jeanette Axelsson, Ernie Bailey, Danika Bannasch, Matthew M Binns, Alexandre S Borges, Pieter Brama, Artur da Câmara Machado, Ottmar Distl, Michela Felicetti, Laura Fox-Clipsham, Kathryn T Graves, Gérard Guérin, Bianca Haase, Telhisa Hasegawa, Karin Hemmann, Emmeline W Hill, Tosso Leeb, Gabriella Lindgren, Hannes Lohi, Maria Susana Lopes, Beatrice A McGivney, Sofia Mikko, Nicholas Orr, M Cecilia T Penedo, Richard J Piercy, Marja Raekallio, Stefan Rieder, Knut H Røed, Maurizio Silvestrelli, June Swinburne, Teruaki Tozaki, Mark Vaudin, Claire M Wade, Molly E McCue
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54997 (2013)
Horses were domesticated from the Eurasian steppes 5,000-6,000 years ago. Since then, the use of horses for transportation, warfare, and agriculture, as well as selection for desired traits and fitness, has resulted in diverse populations distributed
Externí odkaz:
https://doaj.org/article/e6c020bd475a43c5bb2102df8d1b0e7f
Autor:
Jessica L Petersen, James R Mickelson, Aaron K Rendahl, Stephanie J Valberg, Lisa S Andersson, Jeanette Axelsson, Ernie Bailey, Danika Bannasch, Matthew M Binns, Alexandre S Borges, Pieter Brama, Artur da Câmara Machado, Stefano Capomaccio, Katia Cappelli, E Gus Cothran, Ottmar Distl, Laura Fox-Clipsham, Kathryn T Graves, Gérard Guérin, Bianca Haase, Telhisa Hasegawa, Karin Hemmann, Emmeline W Hill, Tosso Leeb, Gabriella Lindgren, Hannes Lohi, Maria Susana Lopes, Beatrice A McGivney, Sofia Mikko, Nicholas Orr, M Cecilia T Penedo, Richard J Piercy, Marja Raekallio, Stefan Rieder, Knut H Røed, June Swinburne, Teruaki Tozaki, Mark Vaudin, Claire M Wade, Molly E McCue
Publikováno v:
PLoS Genetics, Vol 9, Iss 1, p e1003211 (2013)
Intense selective pressures applied over short evolutionary time have resulted in homogeneity within, but substantial variation among, horse breeds. Utilizing this population structure, 744 individuals from 33 breeds, and a 54,000 SNP genotyping arra
Externí odkaz:
https://doaj.org/article/ce64a5c942db42c39626f2e0cfed79e5
Autor:
Rosie J Naylor, Leanda Livesey, John Schumacher, Nicole Henke, Claire Massey, Kenny V Brock, Marta Fernandez-Fuente, Richard J Piercy
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e42317 (2012)
Equine type 1 polysaccharide storage myopathy (PSSM1), a common glycogenosis associated with an R309H founder mutation in the glycogen synthase 1 gene (GYS1), shares pathological features with several human myopathies. In common with related human di
Externí odkaz:
https://doaj.org/article/3b9242210dd94e82a42520a718f75545
Autor:
Gemma L Walmsley, Virginia Arechavala-Gomeza, Marta Fernandez-Fuente, Margaret M Burke, Nicole Nagel, Angela Holder, Rachael Stanley, Kate Chandler, Stanley L Marks, Francesco Muntoni, G Diane Shelton, Richard J Piercy
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8647 (2010)
Duchenne muscular dystrophy (DMD), which afflicts 1 in 3500 boys, is one of the most common genetic disorders of children. This fatal degenerative condition is caused by an absence or deficiency of dystrophin in striated muscle. Most affected patient
Externí odkaz:
https://doaj.org/article/59f7758508614a2ca1aa3bc1b0589163
Autor:
Cajsa M Isgren, Melissa M Upjohn, Marta Fernandez-Fuente, Claire Massey, Geoff Pollott, Kristien L P Verheyen, Richard J Piercy
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11594 (2010)
BACKGROUND: Exertional rhabdomyolysis syndrome is recognised in many athletic horse breeds and in recent years specific forms of the syndrome have been identified. However, although Standardbred horses are used worldwide for racing, there is a paucit
Externí odkaz:
https://doaj.org/article/6bcf1bf0b7e848e5abc6b7362c2a39ba