Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Richard J Perrin"'
Autor:
Peter R Millar, Brian A Gordon, Julie K Wisch, Stephanie A Schultz, Tammie LS Benzinger, Carlos Cruchaga, Jason J Hassenstab, Laura Ibanez, Celeste Karch, Jorge J Llibre-Guerra, John C Morris, Richard J Perrin, Charlene Supnet-Bell, Chengjie Xiong, Ricardo F Allegri, Sarah B Berman, Jasmeer P Chhatwal, Patricio A Chrem Mendez, Gregory S Day, Anna Hofmann, Takeshi Ikeuchi, Mathias Jucker, Jae-Hong Lee, Johannes Levin, Francisco Lopera, Yoshiki Niimi, Victor J Sánchez-González, Peter R Schofield, Ana Luisa Sosa-Ortiz, Jonathan Vöglein, for the Dominantly Inherited Alzheimer Network, Randall J Bateman, Beau M Ances, Eric M McDade
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-17 (2023)
Abstract Background “Brain-predicted age” estimates biological age from complex, nonlinear features in neuroimaging scans. The brain age gap (BAG) between predicted and chronological age is elevated in sporadic Alzheimer disease (AD), but is unde
Externí odkaz:
https://doaj.org/article/8a99db29ec9940cf80f47b491f9d122f
Autor:
Abdallah M Eteleeb, Brenna C Novotny, Carolina Soriano Tarraga, Christopher Sohn, Eliza Dhungel, Logan Brase, Aasritha Nallapu, Jared Buss, Fabiana Farias, Kristy Bergmann, Joseph Bradley, Joanne Norton, Jen Gentsch, Fengxian Wang, Albert A Davis, John C Morris, Celeste M Karch, Richard J Perrin, Bruno A Benitez, Oscar Harari
Publikováno v:
PLoS Biology, Vol 22, Iss 4, p e3002607 (2024)
Unbiased data-driven omic approaches are revealing the molecular heterogeneity of Alzheimer disease. Here, we used machine learning approaches to integrate high-throughput transcriptomic, proteomic, metabolomic, and lipidomic profiles with clinical a
Externí odkaz:
https://doaj.org/article/c71d7c799edd465daeb99f4beb049d3a
Autor:
Peter R Millar, Brian A Gordon, Patrick H Luckett, Tammie LS Benzinger, Carlos Cruchaga, Anne M Fagan, Jason J Hassenstab, Richard J Perrin, Suzanne E Schindler, Ricardo F Allegri, Gregory S Day, Martin R Farlow, Hiroshi Mori, Georg Nübling, The Dominantly Inherited Alzheimer Network, Randall J Bateman, John C Morris, Beau M Ances
Publikováno v:
eLife, Vol 12 (2023)
Background: Estimates of ‘brain-predicted age’ quantify apparent brain age compared to normative trajectories of neuroimaging features. The brain age gap (BAG) between predicted and chronological age is elevated in symptomatic Alzheimer disease (
Externí odkaz:
https://doaj.org/article/9106fa4debe1403fbea1c9196d43eb90
Autor:
Muhammad Ali, Yun Ju Sung, Fengxian Wang, Maria V Fernández, John C Morris, Anne M Fagan, Kaj Blennow, Henrik Zetterberg, Amanda Heslegrave, Per M Johansson, Johan Svensson, Bengt Nellgård, Alberto Lleó, Daniel Alcolea, Jordi Clarimon, Lorena Rami, José Luis Molinuevo, Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Christian Haass, Michael Ewers, Johannes Levin, Martin R Farlow, Richard J Perrin, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dominantly Inherited Alzheimer Network (DIAN), Carlos Cruchaga
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0267298 (2022)
Two genetic variants in strong linkage disequilibrium (rs9536314 and rs9527025) in the Klotho (KL) gene, encoding a transmembrane protein, implicated in longevity and associated with brain resilience during normal aging, were recently shown to be ass
Externí odkaz:
https://doaj.org/article/40df32b713724f238a80e782ea644465
Autor:
Richard J Perrin, Jacqueline E Payton, James P Malone, Petra Gilmore, Alan E Davis, Chengjie Xiong, Anne M Fagan, R Reid Townsend, David M Holtzman
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64314 (2013)
Biomarkers are required for pre-symptomatic diagnosis, treatment, and monitoring of neurodegenerative diseases such as Alzheimer's disease. Cerebrospinal fluid (CSF) is a favored source because its proteome reflects the composition of the brain. Idea
Externí odkaz:
https://doaj.org/article/18320a1706b94b3aab85df95fd4776fb
Autor:
Rebecca Craig-Schapiro, Max Kuhn, Chengjie Xiong, Eve H Pickering, Jingxia Liu, Thomas P Misko, Richard J Perrin, Kelly R Bales, Holly Soares, Anne M Fagan, David M Holtzman
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18850 (2011)
Clinicopathological studies suggest that Alzheimer's disease (AD) pathology begins ∼10-15 years before the resulting cognitive impairment draws medical attention. Biomarkers that can detect AD pathology in its early stages and predict dementia onse
Externí odkaz:
https://doaj.org/article/e976640c1c5a4ccea2c12642381fa6f5
Autor:
Richard J Perrin, Rebecca Craig-Schapiro, James P Malone, Aarti R Shah, Petra Gilmore, Alan E Davis, Catherine M Roe, Elaine R Peskind, Ge Li, Douglas R Galasko, Christopher M Clark, Joseph F Quinn, Jeffrey A Kaye, John C Morris, David M Holtzman, R Reid Townsend, Anne M Fagan
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16032 (2011)
BackgroundIdeally, disease modifying therapies for Alzheimer disease (AD) will be applied during the 'preclinical' stage (pathology present with cognition intact) before severe neuronal damage occurs, or upon recognizing very mild cognitive impairmen
Externí odkaz:
https://doaj.org/article/14913627f3684daeb666751f635a0bc9
Autor:
Kurt Farrell, Megan A Iida, Jonathan D Cherry, Alicia Casella, Thor D Stein, Kevin F Bieniek, Jamie M Walker, Timothy E Richardson, Charles L White, Victor E Alvarez, Bertrand R Huber, Dennis W Dickson, Ricardo Insausti, Kristen Dams-O'Connor, Jean-Paul Vonsattel, Andy F Teich, Marla Gearing, Jonathan Glass, Juan C Troncoso, Matthew P Frosch, Bradley T Hyman, Melissa E Murray, Johannes Attems, Margaret E Flanagan, Qinwen Mao, M-Marsel Mesulam, Sandra Weintraub, Randy L Woltjer, Thao Pham, Julia Kofler, Julie A Schneider, Lei Yu, Dushyant P Purohit, Vahram Haroutunian, Patrick R Hof, Sam Gandy, Mary Sano, Thomas G Beach, Wayne Poon, Claudia H Kawas, María M Corrada, Robert A Rissman, Jeff Metcalf, Sara Shuldberg, Bahar Salehi, Peter T Nelson, John Q Trojanowski, Edward B Lee, David A Wolk, Corey T McMillan, C Dirk Keene, Caitlin S Latimer, Thomas J Montine, Gabor G Kovacs, Mirjam I Lutz, Peter Fischer, Richard J Perrin, Nigel J Cairns, Ann C McKee, John F Crary
Publikováno v:
Journal of neuropathology and experimental neurology. 81(10)
Chronic traumatic encephalopathy (CTE) is a tauopathy associated with repetitive mild head impacts characterized by perivascular hyperphosphorylated tau (p-tau) in neurofibrillary tangles (NFTs) and neurites in the depths of the neocortical sulci. In
Autor:
Rebeca Scalco, Yamah Hamsafar, Charles L White, Julie A Schneider, Robert Ross Reichard, Stefan Prokop, Richard J Perrin, Peter T Nelson, Sean Mooney, Andrew P Lieberman, Walter A Kukull, Julia Kofler, Christopher Dirk Keene, Alifiya Kapasi, David J Irwin, David A Gutman, Margaret E Flanagan, John F Crary, Kwun C Chan, Melissa E Murray, Brittany N Dugger
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 82:202-211
Autor:
W. R. Wayne Martin, John R. Younce, Meghan C. Campbell, Brad A. Racette, Scott A. Norris, Mwiza Ushe, Susan Criswell, Albert A. Davis, Isabel Alfradique‐Dunham, Baijayanta Maiti, Nigel J. Cairns, Richard J. Perrin, Paul T. Kotzbauer, Joel S. Perlmutter
Publikováno v:
Annals of Neurology. 93:184-195
The objective of this study was to evaluate the relationship between Parkinson's disease (PD) with dementia and cortical proteinopathies in a large population of pathologically confirmed patients with PD.We reviewed clinical data from all patients wi