Zobrazeno 1 - 10
of 556
pro vyhledávání: '"Richard J Miller"'
Autor:
Jennifer A Watson, Bula J Bhattacharyya, Jada H Vaden, Julie A Wilson, Mert Icyuz, Alan D Howard, Edward Phillips, Tara M DeSilva, Gene P Siegal, Andrew J Bean, Gwendalyn D King, Scott E Phillips, Richard J Miller, Scott M Wilson
Publikováno v:
PLoS Genetics, Vol 11, Iss 6, p e1005290 (2015)
Neurons are particularly vulnerable to perturbations in endo-lysosomal transport, as several neurological disorders are caused by a primary deficit in this pathway. In this report, we used positional cloning to show that the spontaneously occurring n
Externí odkaz:
https://doaj.org/article/4fa74ad0928c45cbb6f41a27408027a2
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128387 (2015)
Inflammatory (classical) monocytes residing in the bone marrow must enter the bloodstream in order to combat microbe infection. These monocytes express high levels of CCR2, a chemokine receptor whose activation is required for them to exit the bone m
Externí odkaz:
https://doaj.org/article/58d5dd0de74e4ba2b4f6c4b94ac0d900
Autor:
Barış Genç, Amiko Krisa Bunag Lagrimas, Pınar Kuru, Robert Hess, Michael William Tu, Daniela Maria Menichella, Richard J Miller, Amy S Paller, P Hande Özdinler
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132815 (2015)
Visualization of peripheral nervous system axons and cell bodies is important to understand their development, target recognition, and integration into complex circuitries. Numerous studies have used protein gene product (PGP) 9.5 [a.k.a. ubiquitin c
Externí odkaz:
https://doaj.org/article/e6c7c98634ad4e688648684127f6c9df
Autor:
Parthiv Haldipur, Gwendolyn S Gillies, Olivia K Janson, Victor V Chizhikov, Divakar S Mithal, Richard J Miller, Kathleen J Millen
Publikováno v:
eLife, Vol 3 (2014)
Loss of Foxc1 is associated with Dandy-Walker malformation, the most common human cerebellar malformation characterized by cerebellar hypoplasia and an enlarged posterior fossa and fourth ventricle. Although expressed in the mouse posterior fossa mes
Externí odkaz:
https://doaj.org/article/6dc0ae03148e442297b9205442a87a09
Autor:
Alia M. Obeidat, Shingo Ishihara, Jun Li, Natalie S. Adamczyk, Lindsey Lammlin, Lucas Junginger, Tristan Maerz, Richard J. Miller, Rachel E. Miller, Anne-Marie Malfait
Publikováno v:
Frontiers in Neuroanatomy, Vol 18 (2024)
ObjectiveKnee joints are densely innervated by nociceptors. In human knees and rodent models, sprouting of nociceptors has been reported in late-stage osteoarthritis (OA). Here, we sought to describe progressive nociceptor remodeling in early and lat
Externí odkaz:
https://doaj.org/article/c82aa8c802ea4995988701bde3079ef6
Autor:
Kathryn M Schultz, Ghazal Banisadr, Ruben O Lastra, Tammy McGuire, John A Kessler, Richard J Miller, Thomas J McGarry
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17736 (2011)
Neural stem cells (NSCs) are the progenitors of neurons and glial cells during both embryonic development and adult life. The unstable regulatory protein Geminin (Gmnn) is thought to maintain neural stem cells in an undifferentiated state while they
Externí odkaz:
https://doaj.org/article/92960afdd1c646fdb00e5a37c6dbd86e
Autor:
Alia M. Obeidat, Matthew J. Wood, Natalie S. Adamczyk, Shingo Ishihara, Jun Li, Lai Wang, Dongjun Ren, David A. Bennett, Richard J. Miller, Anne-Marie Malfait, Rachel E. Miller
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Non-opioid targets are needed for addressing osteoarthritis pain, which is mechanical in nature and associated with daily activities such as walking and climbing stairs. Piezo2 has been implicated in the development of mechanical pain, but t
Externí odkaz:
https://doaj.org/article/222c434eeda94f0a8702d3c3debb578f
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Peripheral neuropathic pain (PNP), neuropathic pain that arises from a damage or disease affecting the peripheral nervous system, is associated with an extremely large disease burden, and there is an increasing and urgent need for new therapies for t
Externí odkaz:
https://doaj.org/article/e8046f63fe4d404490b1fd8f7ed27b8c
Autor:
Robin Vroman, Rahel S. Hunter, Matthew J. Wood, Olivia C. Davis, Zoë Malfait, Dale S. George, Dongjun Ren, Diana Tavares-Ferreira, Theodore J. Price, Richard J. Miller, Anne-Marie Malfait, Fransiska Malfait, Rachel E. Miller, Delfien Syx
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
The extracellular matrix (ECM) is a dynamic structure of molecules that can be divided into six different categories and are collectively called the matrisome. The ECM plays pivotal roles in physiological processes in many tissues, including the nerv
Externí odkaz:
https://doaj.org/article/87f54fe5bb164f508a368543eff00691
Autor:
Richard J. Miller
'Morphine,'writes Richard J. Miller,'is the most significant chemical substance mankind has ever encountered.'So ancient that remains of poppies have been found in Neolithic tombs, it is the most effective drug ever discovered for treating pain.'What
