Zobrazeno 1 - 10 of 52 pro vyhledávání: '"Richard J Mead"'
1
Akademický článek
Mass spectrometry imaging of SOD1 protein-metal complexes in SOD1G93A transgenic mice implicates demetalation with pathology
Autor: Oliver J. Hale, Tyler R. Wells, Richard J. Mead, Helen J. Cooper
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Amyotrophic lateral sclerosis (ALS) is characterized by degeneration of motor neurons in the central nervous system (CNS). Mutations in the metalloenzyme SOD1 are associated with inherited forms of ALS and cause a toxic gain of function thou
Externí odkaz: https://doaj.org/article/43dd0b8021d242968a9526c2e1593cad
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2
Akademický článek
Early detection of motor dysfunction in the SOD1G93A mouse model of Amyotrophic Lateral Sclerosis (ALS) using home cage running wheels.
Autor: Ellen J Bennett, Richard J Mead, Mimoun Azzouz, Pamela J Shaw, Andrew J Grierson
Publikováno v: PLoS ONE, Vol 9, Iss 9, p e107918 (2014)
The SOD1G93A mouse has been used since 1994 for preclinical testing in amyotrophic lateral sclerosis (ALS). Despite recent genetic advances in our understanding of ALS, transgenic mice expressing mutant SOD1 remain the best available, and most widely
Externí odkaz: https://doaj.org/article/b709dfb8daa244d18969cc921db5730c
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3
Akademický článek
Optimised and rapid pre-clinical screening in the SOD1(G93A) transgenic mouse model of amyotrophic lateral sclerosis (ALS).
Autor: Richard J Mead, Ellen J Bennett, Aneurin J Kennerley, Paul Sharp, Claire Sunyach, Paul Kasher, Jason Berwick, Brigitte Pettmann, Guiseppe Battaglia, Mimoun Azzouz, Andrew Grierson, Pamela J Shaw
Publikováno v: PLoS ONE, Vol 6, Iss 8, p e23244 (2011)
The human SOD1(G93A) transgenic mouse has been used extensively since its development in 1994 as a model for amyotrophic lateral sclerosis (ALS). In that time, a great many insights into the toxicity of mutant SOD1 have been gained using this and oth
Externí odkaz: https://doaj.org/article/0a8e58065d064ae8ae3e91567ca6ba0c
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4
Akademický článek
Janus kinase inhibitors are potential therapeutics for amyotrophic lateral sclerosis
Autor: Peter J. Richardson, Daniel P. Smith, Alex de Giorgio, Xenia Snetkov, Joshua Almond-Thynne, Sara Cronin, Richard J. Mead, Christopher J. McDermott, Pamela J. Shaw
Publikováno v: Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-17 (2023)
Abstract Amyotrophic lateral sclerosis (ALS) is a poorly treated multifactorial neurodegenerative disease associated with multiple cell types and subcellular organelles. As with other multifactorial diseases, it is likely that drugs will need to targ
Externí odkaz: https://doaj.org/article/f1de506708b2457081b6e57e8800b184
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5
Akademický článek
A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations
Autor: Scott P. Allen, Afnan Al Sultan, Elaine Kabucho Kibirige, Erin Tonkiss, Keaton J. Hamer, Lydia M. Castelli, Ya-Hui Lin, Sarah Roscoe, Nikolaos Stefanidis, Richard J. Mead, J. Robin Highley, Johnathan Cooper-Knock, Guillaume M. Hautbergue, Paul R. Heath, Janine Kirby, Pamela J. Shaw
Publikováno v: Frontiers in Aging Neuroscience, Vol 15 (2023)
A p.Y374X truncation in TARDBP was recently shown to reduce expression of TDP43 in fibroblasts isolated from ALS cases. In this follow up study focused on assessing the downstream phenotypic consequences of loss of TDP43 in the context of the truncat
Externí odkaz: https://doaj.org/article/ca2ad4e34a5b4061a9d5da2449950735
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9
Adipose-derived stem cells protect motor neurons and reduce glial activation in both in vitro and in vivo models of ALS
Autor: Laura Ferraiuolo, Noemi Gatto, Andrew J. Grierson, Chloe F. Allen, Richard J. Mead, Yuri Ciervo, Pamela J. Shaw
Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 21, Iss, Pp 413-433 (2021)
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative condition for which new therapeutic options are urgently needed. We injected GFP+ adipose-derived stem cells (EGFP-ADSCs) directly into the cerebrospinal fluid (CSF) of transgenic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57359c003f4b582ff31dd68c8abd43f5
http://www.sciencedirect.com/science/article/pii/S2329050121000577
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10
In Vivo Fiber Optic Raman Spectroscopy of Muscle in Preclinical Models of Amyotrophic Lateral Sclerosis and Duchenne Muscular Dystrophy
Autor: Oliver A C Stevens, Gavin R. Lloyd, Maria Plesia, Richard J. Mead, John C. Day, Pamela J. Shaw, Gaynor Miller, James J.P. Alix, Ian Coldicott, Aneurin J. Kennerley, Catherine Kendall
Publikováno v: ACS Chemical Neuroscience
Plesia, M, Stevens, O A, Lloyd, G R, Kendall, C A, Coldicott, I, Kennerley, A J, Miller, G, Shaw, P J, Mead, R J, Day, J C C & Alix, J J P 2021, ' In Vivo Fiber Optic Raman Spectroscopy of Muscle in Preclinical Models of Amyotrophic Lateral Sclerosis and Duchenne Muscular Dystrophy ', ACS Chemical Neuroscience, vol. 12, no. 10, pp. 1768-1776 . https://doi.org/10.1021/acschemneuro.0c00794
Neuromuscular diseases result in muscle weakness, disability, and, in many instances, death. Preclinical models form the bedrock of research into these disorders, and the development of in vivo and potentially translational biomarkers for the accurat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a0122eb22e0356282a8f3f4125c56d
http://europepmc.org/articles/PMC8154326
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