Výsledky vyhledávání - "Richard J Hackett"

Heartburn sensation in nonerosive reflux disease: pattern of superficial sensory nerves expressing TRPV1 and epithelial cells expressing ASIC3 receptors

Autor: Akinari Sawada, Daniel Sifrim, Wei-Yi Lei, Madusha Peiris, Ahsen Ustaoglu, Philip Woodland, Chien-Lin Chen, Chung Lee, Richard J Hackett

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 320:G804-G815

The underlying causes of heartburn, characteristic symptom of gastroesophageal reflux disease (GERD), remain incompletely understood. Superficial afferent innervation of the esophageal mucosa in nonerosive reflux disease (NERD) may drive nociceptive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6712dea59ff79e1eb7d3143672df85
https://doi.org/10.1152/ajpgi.00013.2021

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Is intracytoplasmic sperm (ICSI) better than traditional in vitro fertilization (IVF): confirmation of higher blastocyst rates per oocyte using a split insemination design

Autor: Shunping Wang, May-Tal Sauerbrun-Cutler, Warren J. Huber, Chloe Shen, Richard J. Hackett, Ruben Alvero, Phinnara Has

Publikováno v: J Assist Reprod Genet

PURPOSE: To explore the effects of traditional vs. intracytoplasmic sperm injection (ICSI) insemination method on the outcome of high-quality blastocyst development in a split sibling oocyte cohort. METHODS: In this retrospective cohort study, we ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e6a8df8971ada134f57545372c5099
https://doi.org/10.1007/s10815-020-01819-1

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Clonal Transitions and Phenotypic Evolution in Barrett's Esophagus

Publikováno v: Evans, J A, Carlotti, E, Lin, M-L, Hackett, R J, Haughey, M J, Passman, A M, Dunn, L, Elia, G, Porter, R J, McLean, M H, Hughes, F, ChinAleong, J, Woodland, P, Preston, S L, Griffin, S M, Lovat, L, Rodriguez-Justo, M, Huang, W, Wright, N A, Jansen, M & McDonald, S A C 2021, ' Clonal Transitions and Phenotypic Evolution in Barrett's Esophagus ', Gastroenterology . https://doi.org/10.1053/j.gastro.2021.12.271

BACKGROUND & AIMS: Barrett's esophagus (BE) is a risk factor for esophageal adenocarcinoma but our understanding of how it evolves is poorly understood. We investigated BE gland phenotype distribution, the clonal nature of phenotypic change, and how

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ce501697431493a43d2e17fdea462c
https://hdl.handle.net/20.500.11820/86dd8044-f515-481a-8ca6-c44362bdc748

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Evolutionary dynamics in Barrett oesophagus: implications for surveillance, risk stratification and therapy

Autor: Stuart McDonald, Melissa Schmidt, Michael Quante, Ann-Marie Baker, Richard J Hackett, Trevor A. Graham

Publikováno v: Nature reviews. Gastroenterologyhepatology. 19(2)

Cancer development is a dynamic evolutionary process characterized by marked intratumoural heterogeneity at the genetic, epigenetic and phenotypic levels. Barrett oesophagus, the pre-malignant condition to oesophageal adenocarcinoma (EAC), is an exem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c21367e867f2c598bc680ab0296de7
https://pubmed.ncbi.nlm.nih.gov/34728819

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Clonal transitions and phenotypic evolution in Barrett esophagus

Autor: M. A. Lin, Emanuela Carlotti, Adam M. Passman, Stuart McDonald, Porter Rj, Nicholas A. Wright, Dunn L, Manuel Rodriguez-Justo, George Elia, Hughes F, S. M. Griffin, Joanne Chin-Aleong, P Woodland, Richard J Hackett, McClean Mh, Marnix Jansen, Laurence Lovat, James A. Evans, Sean L. Preston

Background & AimsBarrett esophagus (BE) is a risk factor for the development of esophageal adenocarcinoma, however our understanding of how Barrett esophagus evolves is still poorly understood. We demonstrate that dynamic clonal phenotypic changes oc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbb41b64ca36f83c378970b64d6a5078
https://doi.org/10.1101/2021.03.31.21252894

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PTU-105 Automated, algorithm based extraction of Barrett’s surveillance metrics from natural language text is reliable

Autor: Aaron Bancil, Jonathan Brown, Sebastian Zeki, Sean L. Preston, Jason M. Dunn, Stuart McDonald, Richard J Hackett, Joanne Chin-Aleong

Publikováno v: Posters.

Introduction Patients with Barrett’s oesophagus (BE) undergo regular endoscopic surveillance with a view to earlier oesophageal adenocarcinoma detection. Quality monitoring of this programme relies on manual extraction of elements from pathology an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68b429107f57ed72f304062043b53844
https://doi.org/10.1136/gutjnl-2019-bsgabstracts.464

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