Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Richard J Gibbons"'
Autor:
David Clynes, Clare Jelinska, Barbara Xella, Helena Ayyub, Stephen Taylor, Matthew Mitson, Csanád Z Bachrati, Douglas R Higgs, Richard J Gibbons
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92915 (2014)
The chromatin remodeling protein ATRX, which targets tandem repetitive DNA, has been shown to be required for expression of the alpha globin genes, for proliferation of a variety of cellular progenitors, for chromosome congression and for the mainten
Externí odkaz:
https://doaj.org/article/99140bda3a2e44e8b0692a5052a6b544
Autor:
Yang Pei, Melanie Tanguy, Adam Giess, Abhijit Dixit, Louise C. Wilson, Richard J. Gibbons, Stephen R. F. Twigg, Greg Elgar, Andrew O. M. Wilkie
Publikováno v:
Genes, Vol 15, Iss 7, p 925 (2024)
The identification of structural variants (SVs) in genomic data represents an ongoing challenge because of difficulties in reliable SV calling leading to reduced sensitivity and specificity. We prepared high-quality DNA from 9 parent–child trios, w
Externí odkaz:
https://doaj.org/article/03729fe8e2f841d1a084ff78ef1650ec
Autor:
David Garrick, Jackie A Sharpe, Ruth Arkell, Lorraine Dobbie, Andrew J H Smith, William G Wood, Douglas R Higgs, Richard J Gibbons
Publikováno v:
PLoS Genetics, Vol 2, Iss 4, p e58 (2006)
ATRX is an X-encoded member of the SNF2 family of ATPase/helicase proteins thought to regulate gene expression by modifying chromatin at target loci. Mutations in ATRX provided the first example of a human genetic disease associated with defects in s
Externí odkaz:
https://doaj.org/article/cc53af1d8839453cb64656e6be6797c5
Autor:
Yavor K. Bozhilov, Damien J. Downes, Jelena Telenius, A. Marieke Oudelaar, Emmanuel N. Olivier, Joanne C. Mountford, Jim R. Hughes, Richard J. Gibbons, Douglas R. Higgs
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The role of promoters as potential insulator elements has been largely unexplored in mammals. Here the authors show that a single nucleotide variant in the α-globin locus forms a new promoter and acts as an orientation-dependent enhancer-blocking in
Externí odkaz:
https://doaj.org/article/0f0ac4b4b81348c696127f64ad73d2ae
Autor:
Christian P. Bradley, Cai Chen, Karolyn A. Oetjen, Cheng Yan, Reema Panjwani, Sara Hauffe, Katherine R. Calvo, Constance Yuan, Prapti Arvind Patel, Nathan D. Montgomery, Matthew C. Foster, Minoo Battiwalla, A.John Barrett, Richard J. Gibbons, Sawa Ito
Publikováno v:
Blood Advances, Vol 3, Iss 17, Pp 2627-2631 (2019)
Externí odkaz:
https://doaj.org/article/5249fe3889db4d9c8c1cfe621009fd18
Autor:
Sachith Mettananda, Chris A. Fisher, Deborah Hay, Mohsin Badat, Lynn Quek, Kevin Clark, Philip Hublitz, Damien Downes, Jon Kerry, Matthew Gosden, Jelena Telenius, Jackie A. Sloane-Stanley, Paula Faustino, Andreia Coelho, Jessica Doondeea, Batchimeg Usukhbayar, Paul Sopp, Jacqueline A. Sharpe, Jim R. Hughes, Paresh Vyas, Richard J. Gibbons, Douglas R. Higgs
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
β-thalassemia is characterised by the presence of an excess of α-globin chains, which contribute to erythrocyte pathology. Here the authors use CRISP/Cas9 to reduce α-globin expression in hematopoietic precursors, and show effectiveness in xenogra
Externí odkaz:
https://doaj.org/article/0cd23b9b09ec4af18f7d483a67ceba18
Autor:
Anna M Rose, Tomas Goncalves, Siobhan Cunniffe, Helene E B Geiller, Thomas Kent, Sam Shepherd, Malitha Ratnaweera, Roderick J O’Sullivan, Richard J Gibbons, David Clynes
Publikováno v:
Nucleic Acids Research.
Telomere maintenance is a hallmark of malignant cells and allows cancers to divide indefinitely. In some cancers, this is achieved through the alternative lengthening of telomeres (ALT) pathway. Whilst loss of ATRX is a near universal feature of ALT-
Autor:
Hsiao P.J. Voon, Jim R. Hughes, Christina Rode, Inti A. De La Rosa-Velázquez, Thomas Jenuwein, Robert Feil, Douglas R. Higgs, Richard J. Gibbons
Publikováno v:
Cell Reports, Vol 11, Iss 3, Pp 405-418 (2015)
Histone H3.3 is a replication-independent histone variant, which replaces histones that are turned over throughout the entire cell cycle. H3.3 deposition at euchromatin is dependent on HIRA, whereas ATRX/Daxx deposits H3.3 at pericentric heterochroma
Externí odkaz:
https://doaj.org/article/d8f015552c51430aaa14198a1da5fae3
Autor:
Sachith Mettananda, Christopher A. Fisher, Jackie A. Sloane-Stanley, Stephen Taylor, Udo Oppermann, Richard J. Gibbons, Douglas R. Higgs
Publikováno v:
Haematologica, Vol 102, Iss 3 (2017)
Externí odkaz:
https://doaj.org/article/efd113be080a4f7194e142c1e725f338
Autor:
Thomas Kent, Sam Shepherd, Sangwoo Kim, Richard J. Gibbons, David Clynes, Tomas Goncalves, Siobhan Cunniffe, Tim Humphrey
A key requisite for indefinite growth of cancer cells is the ability to continuously elongate telomeres to circumvent the onset of senescence or apoptosis. In approximately 10 – 15% of cancers this is achieved through the Alternative Lengthening of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f3ae17a8c1751e0ac6337acbcd54734
https://doi.org/10.21203/rs.3.rs-362334/v1
https://doi.org/10.21203/rs.3.rs-362334/v1