Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Richard J E Armstrong"'
Autor:
Stefano Lise, Yvonne Clarkson, Emma Perkins, Alexandra Kwasniewska, Elham Sadighi Akha, Ricardo Parolin Schnekenberg, Daumante Suminaite, Jilly Hope, Ian Baker, Lorna Gregory, Angie Green, Chris Allan, Sarah Lamble, Sandeep Jayawant, Gerardine Quaghebeur, M Zameel Cader, Sarah Hughes, Richard J E Armstrong, Alexander Kanapin, Andrew Rimmer, Gerton Lunter, Iain Mathieson, Jean-Baptiste Cazier, David Buck, Jenny C Taylor, David Bentley, Gilean McVean, Peter Donnelly, Samantha J L Knight, Mandy Jackson, Jiannis Ragoussis, Andrea H Németh
Publikováno v:
PLoS Genetics, Vol 8, Iss 12, p e1003074 (2012)
β-III spectrin is present in the brain and is known to be important in the function of the cerebellum. Heterozygous mutations in SPTBN2, the gene encoding β-III spectrin, cause Spinocerebellar Ataxia Type 5 (SCA5), an adult-onset, slowly progressiv
Externí odkaz:
https://doaj.org/article/17f69ae6826a45c49f36daa08c4089a0
Autor:
Carrie B. Hurelbrink, Richard J. E. Armstrong, Roger A. Barker, Stephen B. Dunnett, Anne E. Rosser
Publikováno v:
Cell Transplantation, Vol 9 (2000)
The use of fresh human fetal tissue in neural transplantation presents considerable logistical difficulties and limits the clinical applicability of this promising therapy. This study compared the survival of human fetal striatal tissue that had been
Externí odkaz:
https://doaj.org/article/bbad5021b0d84ad686655288477a4f1e
Publikováno v:
Cell Transplantation, Vol 9 (2000)
A large number of crippling neurological conditions result from the loss of certain cell populations from the nervous system through disease or injury, and these cells are not intrinsically replaced. Mounting evidence now suggests that replacement of
Externí odkaz:
https://doaj.org/article/332edaa4d4ca4425852bddda01631209
Autor:
Richard J. E. Armstrong
Publikováno v:
Bereavement Care. 31:25-29
Bereavement and mourning frequently occur as subjects in fiction and poetry. This paper, based on a larger piece of research, explores mourning as it is articulated in film. Starting with an overview of literary and cinematic representations of loss
Publikováno v:
Cell Transplantation, Vol 15 (2006)
Parkinson's disease (PD), while primarily associated with degeneration of nigrostriatal dopamine neurons, is now increasingly recognized to have more widespread cell loss and so the most effective cell replacement therapy should target all these neur
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 74:553-557
The therapeutic implications and application of stem cells for the nervous system There has recently been a great deal of interest in stem cells and the nervous system, in terms of their potential for deciphering developmental issues as well as their
Autor:
Roger A. Barker, Carrie B. Hurelbrink, Stephen B. Dunnett, Richard J. E. Armstrong, Emma Ratcliffe, Andrew Richards, Anne Elizabeth Rosser, Pam Tyers
Publikováno v:
Experimental Neurology. 175:98-111
Neural precursors with the properties of neural stem cells can be isolated from the developing brain, can be expanded in culture, and have been suggested as a potential source of cells for neuronal replacement therapies in degenerative disorders such
Publikováno v:
Expert Opinion on Therapeutic Patents. 11:1563-1582
Disease of the nervous system causes considerable suffering, places a large economic burden on society and, to date, remains relatively untapped by pharmaceutical and biotechnology companies. The burgeoning field of stem cell biology promises to revo
Autor:
Roger A. Barker, Timothy Harrower, Carrie B. Hurelbrink, Andrew Richards, Richard J. E. Armstrong, Emma Ratcliffe, Stephen B. Dunnett, Anne Elizabeth Rosser, M. McLaughin, P. Tyers
Publikováno v:
Neuroscience. 106:201-216
Intracerebral neural xenografts elicit a host immune response that results in their rapid rejection. This forms a key barrier to the therapeutic use of xenogeneic tissue transplantation for conditions such as Parkinson's disease. The current study so
Autor:
Stephen B. Dunnett, Carrie B. Hurelbrink, Anne Elizabeth Rosser, Roger A. Barker, Richard J. E. Armstrong, Leila M. Luheshi
Publikováno v:
Experimental Neurology. 171:46-58
Caspases are cysteine proteases involved in apoptotic cell death, and pharmacological caspase inhibition has been demonstrated to prevent neuronal cell death in certain experimental paradigms. In this study, the role of caspase-1 and -3 in the death