Výsledky vyhledávání - "Richard J Bold"

Akademický článek

Increased Rates of Prolonged Length of Stay, Readmissions, and Discharge to Care Facilities among Postoperative Patients with Disseminated Malignancy: Implications for Clinical Practice.

Autor: Sarah B Bateni, Frederick J Meyers, Richard J Bold, Robert J Canter

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0165315 (2016)

The impact of surgery on end of life care for patients with disseminated malignancy (DMa) is incompletely characterized. The purpose of this study was to evaluate postoperative outcomes impacting quality of care among DMa patients, specifically prolo

Externí odkaz: https://doaj.org/article/cdb779cd0d1045648772c45412102d2c

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Akademický článek

Regionalization of pancreatic surgery in California: Benefits for preventing postoperative deaths and reducing healthcare costs

Autor: Lauren M. Perry, MD, Robert J. Canter, MD, Cameron E. Gaskill, MD, MPH, Richard J. Bold, MD, MBA

Publikováno v: Surgery Open Science, Vol 16, Iss , Pp 198-204 (2023)

Introduction: Pancreatic cancer (PC) surgery has been associated with improved outcomes and value when performed at high-volume centers (HVC; ≥20 surgeries annually) compared to low-volume centers (LVC). Some have used these differences to suggest

Externí odkaz: https://doaj.org/article/7758eb4898ba4962bcd03c8b5023d386

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Akademický článek

Whole-genome bisulfite sequencing identifies stage- and subtype-specific DNA methylation signatures in pancreatic cancer

Autor: Sarah S. Wang, Madison L. Hall, EunJung Lee, Soon-Chan Kim, Neha Ramesh, Sang Hyub Lee, Jin-Young Jang, Richard J. Bold, Ja-Lok Ku, Chang-Il Hwang

Publikováno v: iScience, Vol 27, Iss 4, Pp 109414- (2024)

Summary: In pancreatic ductal adenocarcinoma (PDAC), no recurrent metastasis-specific mutation has been found, suggesting that epigenetic mechanisms, such as DNA methylation, are the major contributors of late-stage disease progression. Here, we perf

Externí odkaz: https://doaj.org/article/b585b1d868174aa89f6764d299282f5f

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Akademický článek

RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)

Enhanced cholesterol biosynthesis is associated with cancer progression. Here the authors identify the nuclear receptor RORγ as a novel master regulator of cholesterol metabolism in triple negative breast cancer (TNBC) and find that RORγ small-mole

Externí odkaz: https://doaj.org/article/985e83249405455e850f73d41a842e97

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Table S2 from Preclinical Development and First-in-Human Imaging of the Integrin αvβ6 with [18F]αvβ6-Binding Peptide in Metastatic Carcinoma

Autor: Julie L. Sutcliffe, Edward J. Kim, Cameron C. Foster, Ryan A. Davis, Megan E. Daly, Helen K. Chew, Lina Y. Cheuy, Richard J. Bold, Sven H. Hausner

Shows the biodistribution data for [18F]αvβ6-BP in mice bearing paired αvβ6-expressing DX3puroβ6 and non-αvβ6-expressing DX3puro xenograft tumors at 1, 2 and 4 h p.i. and at 1 h p.i. after pre-administration of blocking peptide. Tissue uptake

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78af266f4811fbf64af07f8e9bde8240
https://doi.org/10.1158/1078-0432.22467603.v1

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Data from Preclinical Development and First-in-Human Imaging of the Integrin αvβ6 with [18F]αvβ6-Binding Peptide in Metastatic Carcinoma

Autor: Julie L. Sutcliffe, Edward J. Kim, Cameron C. Foster, Ryan A. Davis, Megan E. Daly, Helen K. Chew, Lina Y. Cheuy, Richard J. Bold, Sven H. Hausner

Purpose:The study was undertaken to develop and evaluate the potential of an integrin αvβ6-binding peptide (αvβ6-BP) for noninvasive imaging of a diverse range of malignancies with PET.Experimental Design:The peptide αvβ6-BP was prepared on sol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405e7502a084ce6f15ffd02e8f1fe0fa
https://doi.org/10.1158/1078-0432.c.6526695.v1

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Figure S2 from Preclinical Development and First-in-Human Imaging of the Integrin αvβ6 with [18F]αvβ6-Binding Peptide in Metastatic Carcinoma

Autor: Julie L. Sutcliffe, Edward J. Kim, Cameron C. Foster, Ryan A. Davis, Megan E. Daly, Helen K. Chew, Lina Y. Cheuy, Richard J. Bold, Sven H. Hausner

Shows the in vivo stability of [18F]αvβ6-BP in human blood. Representative radio-HPLC of blood sample taken 30 min post injection. Top: Sample only; bottom: sample spiked with [18F]αvβ6-BP. X-axis: retention time [min]; Y-axis: detector response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c46e86ac37f7576a9f3f73d85ecbe1
https://doi.org/10.1158/1078-0432.22467612.v1

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