Výsledky vyhledávání - "Richard I. Weiner"

Akademický článek

Estrogen receptor beta-selective agonists stimulate calcium oscillations in human and mouse embryonic stem cell-derived neurons.

Autor: Lili Zhang, Brigitte E Blackman, Marcus D Schonemann, Tatjana Zogovic-Kapsalis, Xiaoyu Pan, Mary Tagliaferri, Heather A Harris, Isaac Cohen, Renee A Reijo Pera, Synthia H Mellon, Richard I Weiner, Dale C Leitman

Publikováno v: PLoS ONE, Vol 5, Iss 7, p e11791 (2010)

Estrogens are used extensively to treat hot flashes in menopausal women. Some of the beneficial effects of estrogens in hormone therapy on the brain might be due to nongenomic effects in neurons such as the rapid stimulation of calcium oscillations.

Externí odkaz: https://doaj.org/article/01c40b91eae94910a5662c41afd7e3c0

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Decreased Expression of A-Kinase Anchoring Protein 150 in GT1 Neurons Decreases Neuron Excitability and Frequency of Intrinsic Gonadotropin-Releasing Hormone Pulses

Autor: Qiumei Chen, Richard I. Weiner, Brigitte E. Blackman

Publikováno v: Endocrinology. 151:281-290

The frequency of intrinsic pulsatile GnRH secretion from endogenous GnRH neurons and GT1 GnRH cell lines is stimulated by increased intracellular cAMP levels. The downstream molecules comprising the cAMP signaling pathway are organized in microdomain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::053a6dfad365bbdfe9d87e6cfe579d36
https://doi.org/10.1210/en.2009-0894

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Frequency of Intrinsic Pulsatile Gonadotropin-Releasing Hormone Secretion Is Regulated by the Expression of Cyclic Nucleotide-Gated Channels in GT1 Cells

Autor: Richard I. Weiner, Brigitte E. Blackman, Sreenivasan Paruthiyil, Hiroshi Yoshida

Publikováno v: Endocrinology. 148:3299-3306

Cultures of endogenous GnRH neurons and the GT1 GnRH neuronal cell line release GnRH in pulses (intrinsic pulsatile release) with an interpulse frequency similar to that seen in castrated animals. In both GT1 cells and transgenic rats, lowering cAMP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3283b81415de00de3cd750ebce1ee449
https://doi.org/10.1210/en.2006-1427

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Intermolecular interactions of homologs of germ plasm components in mammalian germ cells

Autor: Chris E. Hostetler, Richard I. Weiner, Jean-Louis Vigne, Michael D. Griswold, Mohammed El Majdoubi, Renee A. Reijo Pera, Mark S. Fox, Amander T. Clark, Jun Urano

Publikováno v: Developmental Biology. 301(2):417-431

In some species such as flies, worms, frogs and fish, the key to forming and maintaining early germ cell populations is the assembly of germ plasm, microscopically distinct egg cytoplasm that is rich in RNAs, RNA-binding proteins and ribosomes. Cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1224f365c038af3fdde0c6a8eacf6a6

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Targeted Expression of a Dominant-Negative Fibroblast Growth Factor (FGF) Receptor in Gonadotropin-Releasing Hormone (GnRH) Neurons Reduces FGF Responsiveness and the Size of GnRH Neuronal Population

Autor: Mohammed El Majdoubi, Richard I. Weiner, Sabine Werner, Hector Postigo, Suzanne M. Moenter, Toni R. Pak, Pei-San Tsai, Sreenivasan Paruthiyil, John C. Gill

Publikováno v: Molecular Endocrinology. 19:225-236

Increasing evidence suggests that fibroblast growth factors (FGFs) are neurotrophic in GnRH neurons. However, the extent to which FGFs are involved in establishing a functional GnRH system in the whole organism has not been investigated. In this stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d30a5d71fc9230ff7da2b96511f8b44
https://doi.org/10.1210/me.2004-0330

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Decreased gonadotropin-releasing hormone neuronal activity is associated with decreased fertility and dysregulation of food intake in the female GPR-4 transgenic rat

Autor: Francisca Gomez, Richard I. Weiner, Mohammed El Majdoubi, Mary F. Dallman, Susanne E. la Fleur

Publikováno v: Endocrinology, 146(9), 3800-3808. The Endocrine Society

Expression of a cAMP-specific phosphodiesterase in GnRH neurons in the GPR-4 transgenic rat resulted in decreased LH levels and pulse frequency and diminished fertility. We have characterized changes in fertility, adiposity, and reproductive and meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f1c1c1c50ca6644c3da8265bfc03c9
https://doi.org/10.1210/en.2005-0369

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Lowering Cyclic Adenosine-3′,5′-Monophosphate (cAMP) Levels by Expression of a cAMP-Specific Phosphodiesterase Decreases Intrinsic Pulsatile Gonadotropin-Releasing Hormone Secretion from GT1 Cells

Autor: Andrew Charles, Hiroshi Yoshida, Marco Conti, Luis Beltran-Parrazal, Paul Butler, Richard I. Weiner

Publikováno v: Molecular Endocrinology. 17:1982-1990

Pulsatile GnRH secretion is an intrinsic property of GnRH neurons. Since increases in cAMP levels increase excitability and GnRH secretion in the GT1-1 GnRH cell line, we asked whether cAMP levels play a role in timing excitability and intrinsic puls

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87bc80f144c9945b6ab3065032397de3
https://doi.org/10.1210/me.2003-0059

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The Antiangiogenic Factor 16K Human Prolactin Induces Caspase-Dependent Apoptosis by a Mechanism that Requires Activation of Nuclear Factor-κB

Autor: Ingrid Struman, Richard I. Weiner, Sébastien Tabruyn, Joseph Martial, Vincent Bours, Françoise Rentier-Delrue, Catherine M. Sorlet

Publikováno v: Molecular Endocrinology. 17:1815-1823

We have previously shown that the 16-kDa N-terminal fragment of human prolactin (16K hPRL) has antiangiogenic properties, including the ability to induce apoptosis in vascular endothelial cells. Here, we examined whether the nuclear factor-kappaB (NF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c5695e3c82b254c6fea10fee260915
https://doi.org/10.1210/me.2003-0132

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Pulsatile Luteinizing Hormone and Follicle-Stimulating Hormone Secretion and Gonadotropin Subunit mRNA Levels in the Ovariectomized GPR-4 Transgenic Rat

Autor: Richard I. Weiner, Sreenivasan Paruthiyil, Mohammed El Majdoubi

Publikováno v: Neuroendocrinology. 78:287-293

Genetic targeting of the cAMP-specific phosphodiesterase 4D1 (PDE4D1) to gonadotropin-releasing hormone (GnRH) neurons in the GPR-4 transgenic rat resulted in decreased luteinizing hormone (LH) pulse frequency in castrated female and male rats. A sim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a38d6f639766d06cc32369dc7425a0fd
https://doi.org/10.1159/000074881

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