Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Richard I. Tuxworth"'
Autor:
Zubair Ahmed, Richard I. Tuxworth
Publikováno v:
Clinical and Translational Discovery, Vol 2, Iss 3, Pp n/a-n/a (2022)
Abstract Spinal cord injury (SCI) affects up to 1.26 million people every year, leading to permanent disability and death. The biggest causes of SCI are motor vehicle accidents, falls and interpersonal violence with clinical outcomes very much depend
Externí odkaz:
https://doaj.org/article/5fda5e400e2644c0a73fd2c4c671a9c0
Autor:
Zubair Ahmed, Richard I. Tuxworth
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 7, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/4892a83fcac645cc8a7b9f7ffcb14a9d
Autor:
Kyle J. Connolly, Megan B. O’Hare, Alamin Mohammed, Katelyn M. Aitchison, Niki C. Anthoney, Matthew J. Taylor, Bryan A. Stewart, Richard I. Tuxworth, Guy Tear
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Abstract The neuronal ceroid lipofuscinoses (NCLs) are a group of fatal, monogenic neurodegenerative disorders with an early onset in infancy or childhood. Despite identification of the genes disrupted in each form of the disease, their normal cellul
Externí odkaz:
https://doaj.org/article/2dfeb1df3f464c07b371924c3830b445
Publikováno v:
Neurobiology of Disease, Vol 103, Iss , Pp 123-132 (2017)
The neuronal ceroid lipofuscinoses are a group of recessively inherited, childhood-onset neurodegenerative conditions. Several forms are caused by mutations in genes encoding putative lysosomal membrane proteins. Studies of the cell biology underpinn
Externí odkaz:
https://doaj.org/article/f7ddc8dbdb43437bbe789b3963653a13
Publikováno v:
Biology Open, Vol 3, Iss 1, Pp 1-11 (2013)
Summary Hyperphosphorylation of the microtubule associated protein, Tau, is the hallmark of a group of neurodegenerative disorders known as the tauopathies which includes Alzheimer's disease. Precisely how and why Tau phosphorylation is increased in
Externí odkaz:
https://doaj.org/article/4904fa645e094147818f971a452f62d3
Publikováno v:
Science advances. 8(37)
DNA double-strand breaks occur in many acute and long-term neurological conditions, including neurodegeneration, neurotrauma, and stroke. Nonrepaired breaks chronically activate the DNA damage response in neurons, leading to neural dysfunction and ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd726aef5f04093056e3efd348b83b29
https://pubmed.ncbi.nlm.nih.gov/36103534
https://pubmed.ncbi.nlm.nih.gov/36103534
Continuous tracking of startled Drosophila as an alternative to the negative geotaxis climbing assay
Autor:
Richard I. Tuxworth, Matthew J. Taylor
Publikováno v:
Journal of Neurogenetics. 33:190-198
The fruit fly, Drosophila, is commonly used to study late-onset neurodegenerative diseases due to the combination of powerful genetic tools, cheap and simple husbandry and short lifespan. One widely-used measure of disease progression is the age-depe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa89a40405b0cabf2ca99ca5d0ab6d5e
https://doi.org/10.1080/01677063.2019.1634065
https://doi.org/10.1080/01677063.2019.1634065
Autor:
Matthew J, Taylor, Richard I, Tuxworth
Publikováno v:
Journal of neurogenetics. 33(3)
The fruit fly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a93e0aaddc3bae57aa7d9da553891555
https://pubmed.ncbi.nlm.nih.gov/31290369
https://pubmed.ncbi.nlm.nih.gov/31290369
Autor:
Robert J. Huber, Claire Russell, Wenfei Liu, Stephanie M. Hughes, Alan Morgan, Richard I. Tuxworth
Publikováno v:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Biochimica et Biophysica Acta-Molecular Basis of Disease
Biochimica et Biophysica Acta-Molecular Basis of Disease
The NCLs (neuronal ceroid lipofuscinosis) are forms of neurodegenerative disease that affect people of all ages and ethnicities but are most prevalent in children. Commonly known as Batten disease, this debilitating neurological disorder is comprised
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9792cad7c4af801ca8019847be2e5b15
https://pubmed.ncbi.nlm.nih.gov/31783156
https://pubmed.ncbi.nlm.nih.gov/31783156
Autor:
Richard I. Tuxworth, Ane Martin Anduaga, Alaa Hussien-Ali, Matthew J. Taylor, Adam M. Thompson, Sotiroula Chatzimatthaiou, Pavlos Alifragis, Boris Kysela, Charalambos P. Kyriacou, Joanne Longland, Sharif Almutiri, Zubair Ahmed
Publikováno v:
Brain Communications
DNA double strand breaks feature in neurological disorders, including many forms of neurodegeneration, stroke and acute neurotrauma. Tuxworth et al. show that inhibiting the DNA damage sensing response is neuroprotective, axon regenerative and improv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8793ed66e866197b36212fff03d339e7
https://doi.org/10.1093/braincomms/fcz005
https://doi.org/10.1093/braincomms/fcz005