Zobrazeno 1 - 10
of 327
pro vyhledávání: '"Richard I. Morimoto"'
Autor:
Akira Kitamura, Ai Fujimoto, Rei Kawashima, Yidan Lyu, Kotetsu Sasaki, Yuta Hamada, Kanami Moriya, Ayumi Kurata, Kazuho Takahashi, Reneé Brielmann, Laura C. Bott, Richard I. Morimoto, Masataka Kinjo
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-21 (2024)
Abstract Carboxy terminal fragments (CTFs) of TDP-43 contain an intrinsically disordered region (IDR) and form cytoplasmic condensates containing amyloid fibrils. Such condensates are toxic and associated with pathogenicity in amyotrophic lateral scl
Externí odkaz:
https://doaj.org/article/edf11e8a7f974a75b2d3e0e0a54b502f
Autor:
Pathum M. Weerawarna, Isaac T. Schiefer, Pedro Soares, Susan Fox, Richard I. Morimoto, Rafael D. Melani, Neil L. Kelleher, Chi-Hao Luan, Richard B. Silverman
Publikováno v:
ACS Central Science, Vol 10, Iss 1, Pp 87-103 (2023)
Externí odkaz:
https://doaj.org/article/ba3032efe9234196b66de6d2dfb01321
Autor:
Prajwal Ciryam, Matthew Antalek, Fernando Cid, Gian Gaetano Tartaglia, Christopher M. Dobson, Anne-Katrin Guettsches, Britta Eggers, Matthias Vorgerd, Katrin Marcus, Rudolf A. Kley, Richard I. Morimoto, Michele Vendruscolo, Conrad C. Weihl
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-14 (2019)
Abstract Protein aggregation is a pathological feature of neurodegenerative disorders. We previously demonstrated that protein inclusions in the brain are composed of supersaturated proteins, which are abundant and aggregation-prone, and form a metas
Externí odkaz:
https://doaj.org/article/98b5bb1d9beb43de9d33f052fb29e0d6
Autor:
Johnathan Labbadia, Renee M. Brielmann, Mario F. Neto, Yi-Fan Lin, Cole M. Haynes, Richard I. Morimoto
Publikováno v:
Cell Reports, Vol 21, Iss 6, Pp 1481-1494 (2017)
Summary: In Caenorhabditis elegans, the programmed repression of the heat shock response (HSR) accompanies the transition to reproductive maturity, leaving cells vulnerable to environmental stress and protein aggregation with age. To identify the fac
Externí odkaz:
https://doaj.org/article/7c5dd2b3a2014fc6a1d3dc2c7ac4051e
Autor:
Marc Brehme, Cindy Voisine, Thomas Rolland, Shinichiro Wachi, James H. Soper, Yitan Zhu, Kai Orton, Adriana Villella, Dan Garza, Marc Vidal, Hui Ge, Richard I. Morimoto
Publikováno v:
Cell Reports, Vol 9, Iss 3, Pp 1135-1150 (2014)
Chaperones are central to the proteostasis network (PN) and safeguard the proteome from misfolding, aggregation, and proteotoxicity. We categorized the human chaperome of 332 genes into network communities using function, localization, interactome, a
Externí odkaz:
https://doaj.org/article/a7c4790bcaa740b184e1aecb1dd3a085
Autor:
Prajwal Ciryam, Gian Gaetano Tartaglia, Richard I. Morimoto, Christopher M. Dobson, Michele Vendruscolo
Publikováno v:
Cell Reports, Vol 5, Iss 3, Pp 781-790 (2013)
The maintenance of protein solubility is a fundamental aspect of cellular homeostasis because protein aggregation is associated with a wide variety of human diseases. Numerous proteins unrelated in sequence and structure, however, can misfold and agg
Externí odkaz:
https://doaj.org/article/f636dedaca1440e389ed7abd3e2d1aac
Publikováno v:
Neurobiology of Disease, Vol 40, Iss 1, Pp 12-20 (2010)
Adult-onset neurodegeneration and other protein conformational diseases are associated with the appearance, persistence, and accumulation of misfolded and aggregation-prone proteins. To protect the proteome from long-term damage, the cell expresses a
Externí odkaz:
https://doaj.org/article/ebf384fb01eb46da99aedde1a4213a8e
Autor:
Thomas Stoeger, Rogan A. Grant, Alexandra C. McQuattie-Pimentel, Kishore R. Anekalla, Sophia S. Liu, Heliodoro Tejedor-Navarro, Benjamin D. Singer, Hiam Abdala-Valencia, Michael Schwake, Marie-Pier Tetreault, Harris Perlman, William E. Balch, Navdeep S. Chandel, Karen M. Ridge, Jacob I. Sznajder, Richard I. Morimoto, Alexander V. Misharin, G. R. Scott Budinger, Luis A. Nunes Amaral
Publikováno v:
Nature Aging. 2:1191-1206
Aging is among the most important risk factors for morbidity and mortality. To contribute toward a molecular understanding of aging, we analyzed age-resolved transcriptomic data from multiple studies. Here, we show that transcript length alone explai
Autor:
Ambre J. Sala, Rogan A. Grant, Ghania Imran, Claire Morton, Renee M. Brielmann, Laura C. Bott, Jennifer Watts, Richard I. Morimoto
The ability to sense and respond to proteotoxic insults declines with age, leaving cells vulnerable to chronic and acute stressors. Reproductive cues modulate this decline in cellular proteostasis to influence organismal stress resilience inC. elegan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abb8aaa76c9f520b2b940b5c37c40346
https://doi.org/10.1101/2023.04.25.537803
https://doi.org/10.1101/2023.04.25.537803
Autor:
Ambre Sala, Richard I. Morimoto
Publikováno v:
Trends Cell Biol
The proteostasis network (PN) regulates protein synthesis, folding, and degradation, and is critical for the health and function of all cells. The PN has been extensively studied in the context of aging and age-related diseases, and loss of proteosta