Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Richard I Hume"'
Autor:
Jiaxing Li, Yao V Zhang, Elham Asghari Adib, Doychin T Stanchev, Xin Xiong, Susan Klinedinst, Pushpanjali Soppina, Thomas Robert Jahn, Richard I Hume, Tobias M Rasse, Catherine A Collins
Publikováno v:
eLife, Vol 6 (2017)
The kinesin-3 family member Unc-104/KIF1A is required for axonal transport of many presynaptic components to synapses, and mutation of this gene results in synaptic dysfunction in mice, flies and worms. Our studies at the Drosophila neuromuscular jun
Externí odkaz:
https://doaj.org/article/79619f4a1fa4450f97a7863533408fc2
Autor:
Xin Xiong, Yan Hao, Kan Sun, Jiaxing Li, Xia Li, Bibhudatta Mishra, Pushpanjali Soppina, Chunlai Wu, Richard I Hume, Catherine A Collins
Publikováno v:
PLoS Biology, Vol 10, Iss 12, p e1001440 (2012)
Axonal degeneration is a hallmark of many neuropathies, neurodegenerative diseases, and injuries. Here, using a Drosophila injury model, we have identified a highly conserved E3 ubiquitin ligase, Highwire (Hiw), as an important regulator of axonal an
Externí odkaz:
https://doaj.org/article/6471351081554ec7bb481ccd5535921e
Autor:
Shlomo S Dellal, Richard I Hume
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47147 (2012)
Rat P2X2 receptors open at an undetectably low rate in the absence of ATP. Furthermore, two allosteric modulators, zinc and acidic pH, cannot by themselves open these channels. We describe here the properties of a mutant receptor, K69C, before and af
Externí odkaz:
https://doaj.org/article/35eeb3a1e4314149bba4d3f7d6f79053
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Stac3 regulates excitation-contraction coupling (EC coupling) in vertebrate skeletal muscles by regulating the L-type voltage-gated calcium channel (Cav channel). Recently a stac-like gene, Dstac, was identified in Drosophila and found to be expresse
Externí odkaz:
https://doaj.org/article/4d5487f3d3204588bf7575bb932ab900
Autor:
Allison M Orzel, Richard I. Hume, Miranda C Lum, Lilly E. Reid, Catherine A. Collins, Jade E Varineau, Edwin S. Levitan, John Y. Kuwada, Haoxing Xu, Ari Leflein, Xiaoli Zhang, Jeremy W. Linsley, Drew A Berkhoudt, I-Uen Hsu
Publikováno v:
Proc Natl Acad Sci U S A
Significance Many neurons release neuropeptides as well as classical neurotransmitters. Neuropeptides often regulate neural circuits controlling behaviors such as emotional behaviors. However, how neuropeptide release is regulated is not well-underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144c861eee26045445989fff66ac1a7a
https://doi.org/10.1073/pnas.2009224117
https://doi.org/10.1073/pnas.2009224117
Autor:
Timothy L. Cover, Zhuang Zhuang Zhao, Mingxue Gu, Raif S. Geha, Rajan Sah, Janet Chou, Richard I. Hume, Haoxing Xu, Yexin Yang, Ping Li, Nirakar Sahoo, Fernando Benavides, Shiyu Xiao, Xinghua Feng, Meiqin Hu, Ce Wang, Ying Yang
Publikováno v:
Proc Natl Acad Sci U S A
LRRC8 family proteins on the plasma membrane play a critical role in cellular osmoregulation by forming volume-regulated anion channels (VRACs) necessary to prevent necrotic cell death. We demonstrate that intracellular LRRC8 proteins acting within l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e396dbc288615ecd6ceb6dde9c53f2ba
https://doi.org/10.1073/pnas.2016539117
https://doi.org/10.1073/pnas.2016539117
Autor:
Meiqin Hu, Ping Li, Ce Wang, Xinghua Feng, Qi Geng, Wei Chen, Matangi Marthi, Wenlong Zhang, Chenlang Gao, Whitney Reid, Joel Swanson, Wanlu Du, Richard I. Hume, Haoxing Xu
Publikováno v:
Cell
Lysosomes require an acidic lumen between pH 4.5 and 5.0 for effective digestion of macromolecules. This pH optimum is maintained by proton influx produced by the V-ATPase and efflux through an unidentified “H(+) leak” pathway. Here we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc42328d0c357d54b3313491f928b5a
https://doi.org/10.1016/j.cell.2022.05.021
https://doi.org/10.1016/j.cell.2022.05.021
Autor:
Yanxiao Zhang, Catherine A. Collins, Yan Hao, Thomas J. Waller, Richard I. Hume, Jiaxing Li, Melissa M. Rolls, Derek Nye
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(43)
The degeneration of injured axons involves a self-destruction pathway whose components and mechanism are not fully understood. Here, we report a new regulator of axonal resilience. The transmembrane protein Raw is cell autonomously required for the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e08b4e674dab15bfe5cdca33d58625
https://pubmed.ncbi.nlm.nih.gov/31492772
https://pubmed.ncbi.nlm.nih.gov/31492772
Autor:
Doychin T. Stanchev, Jiaxing Li, Pushpanjali Soppina, Susan Klinedinst, Richard I. Hume, Yao V. Zhang, Tobias M. Rasse, Catherine A. Collins, Elham Asghari Adib, Xin Xiong, Thomas R. Jahn
Publikováno v:
eLife
eLife, Vol 6 (2017)
eLife, Vol 6 (2017)
The kinesin-3 family member Unc-104/KIF1A is required for axonal transport of many presynaptic components to synapses, and mutation of this gene results in synaptic dysfunction in mice, flies and worms. Our studies at the Drosophila neuromuscular jun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49d276e0b91d068f2b7426049cf4885
https://doi.org/10.7554/elife.24271
https://doi.org/10.7554/elife.24271
Autor:
Pushpanjali Soppina, Catherine A. Collins, Susan Klinedinst, Yao V. Zhang, Elham Asghari Adib, Tobias M. Rasse, Jiaxing Li, Thomas R. Jahn, Doychin T. Stanchev, Xin Xiong, Richard I. Hume
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::449983e8bde97e1e689bddcbfe69782a
https://doi.org/10.7554/elife.24271.032
https://doi.org/10.7554/elife.24271.032
