Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Richard I Gregory"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The epitranscriptome includes a diversity of RNA modifications that influence gene expression. N3-methylcytidine (m3C) mainly occurs in the anticodon loop (position C32) of certain tRNAs yet its role is poorly understood. Here, using HAC-Seq
Externí odkaz:
https://doaj.org/article/2ea7d80f1e9743a488d59482b7da7097
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Here the authors show the exon junction complex (EJC) component, EIF4A3, locally restricts METTL3- mediated mRNA methylation at exon junctions to explain the observed widespread enrichment of m6A modification in 3’ untranslated regions.
Externí odkaz:
https://doaj.org/article/e279e6d3537a4dc1873aaddbde7c1d8a
Autor:
Julia Ramírez-Moya, Christos Miliotis, Allison R. Baker, Richard I. Gregory, Frank J. Slack, Pilar Santisteban
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-20 (2021)
Abstract Background Adenosine deaminases acting on RNA (ADARs) modify many cellular RNAs by catalyzing the conversion of adenosine to inosine (A-to-I), and their deregulation is associated with several cancers. We recently showed that A-to-I editing
Externí odkaz:
https://doaj.org/article/3ca24ab8383d42e88c0f6bf7dd321fc5
Autor:
Mehdi Pirouz, Chih-Hao Wang, Qi Liu, Aref G. Ebrahimi, Farnaz Shamsi, Yu-Hua Tseng, Richard I. Gregory
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The DIS3L2 exonuclease degrades aberrant 7SL RNAs tagged by an oligouridine 3′-tail. Here the authors analyze DIS3L2 knockout mouse embryonic stem cells and suggest that DIS3L2-mediated quality control of 7SL RNA is important for ER-mediated transl
Externí odkaz:
https://doaj.org/article/740eb5c2c0f64fa4b67534891edef46a
Autor:
Jiazhi Li, Longfei Wang, Quentin Hahn, Radosław P. Nowak, Thibault Viennet, Esteban A. Orellana, Shourya S. Roy Burman, Hong Yue, Moritz Hunkeler, Pietro Fontana, Hao Wu, Haribabu Arthanari, Eric S. Fischer, Richard I. Gregory
Publikováno v:
Nature. 613:391-397
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dde4adaaac843561a25cc65c5e66e4db
https://doi.org/10.1038/s41586-022-05566-4
https://doi.org/10.1038/s41586-022-05566-4
Autor:
Hee Ho Park, Robinson Triboulet, Martin Bentler, Swaroopa Guda, Peng Du, Haiming Xu, Richard I. Gregory, Christian Brendel, David A. Williams
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 12, Iss , Pp 591-599 (2018)
RNAi-based gene therapy using miRNA-adapted short hairpin RNAs (shRNAmiR) is a powerful approach to modulate gene expression. However, we have observed low viral titers with shRNAmiR-containing recombinant vectors and hypothesized that this could be
Externí odkaz:
https://doaj.org/article/eb62eccf6a0348ee95187fcbf30a46c9
Publikováno v:
Nucleic Acids Research. 51:D248-D261
Upstream open reading frames (uORFs) are typically defined as translation sites located within the 5′ untranslated region upstream of the main protein coding sequence (CDS) of messenger RNAs (mRNAs). Although uORFs are prevalent in eukaryotic mRNAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c3b0d0bd0b6b7a29a3f40ae10668483
https://doi.org/10.1093/nar/gkac1094
https://doi.org/10.1093/nar/gkac1094
Publikováno v:
Nature Reviews Genetics. 23:651-664
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::530edd2465318566a452ad2538be2b2a
https://doi.org/10.1038/s41576-022-00501-9
https://doi.org/10.1038/s41576-022-00501-9
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 1861-1873 (2016)
Mutations in the 3′-5′ exonuclease DIS3L2 are associated with Perlman syndrome and hypersusceptibility to Wilms tumorigenesis. Previously, we found that Dis3l2 specifically recognizes and degrades uridylated pre-let-7 microRNA. However, the wides
Externí odkaz:
https://doaj.org/article/c4bbba5dc82b4ca3a9c8a3a2394078a8
Publikováno v:
Frontiers for Young Minds. 11
The cells in your body contain genes made of DNA. Genes store the genetic information passed on to you by your parents. This information serves as the recipe to make proteins, and proteins build, maintain, and heal every tissue in your body. The cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1541eddf605c73e526f9e81e3cefb46
https://doi.org/10.3389/frym.2023.961033
https://doi.org/10.3389/frym.2023.961033